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MONOCLONAL ANTIBODIES TO TARGET NEURONAL POPULATIONS

Award Number: R44MH060063
ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 04/01/1999
PERIOD OF PERFORMANCE END DATE: 01/31/2006

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MONOCLONAL ANTIBODIES TO TARGET NEURONAL POPULATIONS - DESCRIPTION (provided by applicant): This proposal concerns the development of reagents to target specific neuronal populations in vivo with monoclonal antibodies. These reagents will be used in research and therapeutic applications. In Phase I, we developed a monoclonal antibody capable of targeting neuronal transporters. In this Phase II application, the first specific aim proposes to create monoclonal antibodies to the extracellular domains of another important class of cell surface molecules, the G protein-coupled receptors. These receptors play a large role in all aspects of human health, reflecting their widespread presence in the human physiology, especially the nervous systems. The five somatostatin receptors have been selected because of their importance in neuronal systems, biology, and nervous system pathologies. The second specific aim proposes to create recombinant antibodies to these receptors. The best of these antibodies will be modified to demonstrate that biologically active molecules can be inserted into cells that express the somatostatin receptors. The innovations in the proposal are several. The development of reagents for insertion of biologically active cells will be important for developing new treatments for neurodegenerative diseases and pain pathologies, among others. Despite widespread use of recombinant antibodies in cancer biology with their ability to be modified through the construction of fusion proteins, they are still extremely rare and make this a novel approach.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2005 ( Subtotal = $174,879 )
2005	2005	ADVANCED TARGETING SYSTEMS	11175-A FLINTKOTE AVENUE	SAN DIEGO	CA	92121	SAN DIEGO	USA	Mental Health Research Grants	000	4	2/9/2005	NON-COMPETING CONTINUATION	$174,879
														Subtotal = $174,879

Issue Date FY: 2004 ( Subtotal = $282,193 )
2004	2004	ADVANCED TARGETING SYSTEMS	11175-A FLINTKOTE AVENUE	SAN DIEGO	CA	92121	SAN DIEGO	USA	Mental Health Research Grants	000	3	2/5/2004	NON-COMPETING CONTINUATION	$282,193
														Subtotal = $282,193

Issue Date FY: 2003 ( Subtotal = $341,281 )
2003	2003	ADVANCED TARGETING SYSTEMS	11175-A FLINTKOTE AVENUE	SAN DIEGO	CA	92121	SAN DIEGO	USA	Mental Health Research Grants	000	2		COMPETING CONTINUATION	$341,281
														Subtotal = $341,281

Grand Total All Awards = $798,353

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MONOCLONAL ANTIBODIES TO TARGET NEURONAL POPULATIONS

Award Number: R44MH060063

ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 04/01/1999

PERIOD OF PERFORMANCE END DATE: 01/31/2006

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