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sEH Inhibitors to Treat Neuropathic Pain

Award Number: R43ES025598
ORGANIZATION: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/22/2014
PERIOD OF PERFORMANCE END DATE: 02/29/2016

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sEH Inhibitors to Treat Neuropathic Pain - DESCRIPTION (provided by applicant): Pain is a serious health problem affecting a large proportion of the general population. The burden of painful conditions on the individuals and the society follow a rising trajectory because of the paucity of effective and reasonably safe pharmaceuticals that are needed globally. Aging population and diabetes epidemic are two key factors that drive the number of people that will need efficacious analgesics. More than 75% of the analgesic market in volume is dominated by cyclooxygenase inhibitors. However lack of efficacy in neuropathic pain and side effects limit their use. Other approved therapeutics also suffers from lack of efficacy and diverse and serious side effects. This underlines the need to discover novel therapeutic agents to alleviate pain. In order to meet this need, Eicosis' overall objective is the development of a novel promising class of orally active analgesic drug that targets the soluble epoxide hydrolase (sEH), a new therapeutic target for pain. The inhibitors of sEH are not only more efficacious than COX inhibitors on inflammatory pain, but also they block intractable neuropathic pain more efficaciously than commercial standards gabapentin and pregabalin without the motor side effects. In this proposal, Eicosis will identify and select an IN candidate and a back-up compound for the treatment of painful conditions.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2016 ( Subtotal = $0 )
2016	2014	EICOSIS, LLC	1407 NUTMEG LN	DAVIS	CA	956181419	YOLO	USA	Environmental Health	000	1	2/19/2016	NEW	$0
														Subtotal = $0

Issue Date FY: 2014 ( Subtotal = $224,443 )
2014	2014	EICOSIS, LLC	1407 NUTMEG LN	DAVIS	CA	95618	YOLO	USA	Environmental Health	000	1	9/22/2014	NEW	$224,443
														Subtotal = $224,443

Grand Total All Awards = $224,443

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sEH Inhibitors to Treat Neuropathic Pain

Award Number: R43ES025598

ORGANIZATION: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/22/2014

PERIOD OF PERFORMANCE END DATE: 02/29/2016

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