Thursday, February 19, 2026 2/19/2026

Molecular genetics of signaling lipids

Award Number: R35GM153331
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 04/01/2024
PERIOD OF PERFORMANCE END DATE: 01/31/2029

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Molecular genetics of signaling lipids - PROJECT SUMMARY/ABSTRACT Signaling lipids, such as steroids, terpenoids, and eicosanoids, regulate diverse physiological processes in animals, including development, reproduction, and immune responses. Understanding modes of action of such lipid-derived signaling molecules, therefore, is critical for ensuring and promoting healthy development and well-being in humans. However, in contrast to proteinaceous signaling molecules such as peptide hormones and cytokines, the power of modern molecular genetics has not been fully utilized for signaling lipid research, as they are not directly encoded by genes. In the past several years, it has been demonstrated that the insect steroid hormone ecdysone requires membrane transporters for its entry into target cells, challenging the prevailing dogma in endocrinology that lipophilic hormones can simply diffuse across the plasma membrane. As exemplified by this study, there are huge knowledge gaps regarding how signaling lipids function in vivo, particularly concerning their transmembrane transport machineries. This project will utilize fruit fly genetics to reveal uncharacterized aspects of signaling pathways mediated by lipid-derived molecules. The project will focus on three major signaling lipids in insects, namely ecdysone, juvenile hormone, and eicosanoids, to better understand their modes of action. Successful completion of this project is expected not just to broaden our understanding of the functions of signaling lipids in this important model insect species, but also to provide an unprecedented example of a novel type of signaling lipid research and may inspire many researchers in the relevant field.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $346,112 )
2026	2026	REGENTS OF THE UNIVERSITY OF CALIFORNIA AT RIVERSIDE	200 UNIVERSTY OFC BUILDING	RIVERSIDE	CA	92521	RIVERSIDE	USA	Biomedical Research and Research Training	000	3	1/27/2026	NON-COMPETING CONTINUATION	$346,112
														Subtotal = $346,112

Issue Date FY: 2025 ( Subtotal = $384,925 )
2025	2025	REGENTS OF THE UNIVERSITY OF CALIFORNIA AT RIVERSIDE	200 UNIVERSTY OFC BUILDING	RIVERSIDE	CA	92521	RIVERSIDE	USA	Biomedical Research and Research Training	002	2	8/8/2025	NON-COMPETING CONTINUATION	$38,492
2025	2025	REGENTS OF THE UNIVERSITY OF CALIFORNIA AT RIVERSIDE	200 UNIVERSTY OFC BUILDING	RIVERSIDE	CA	92521	RIVERSIDE	USA	Biomedical Research and Research Training	001	2	1/16/2025	NON-COMPETING CONTINUATION	$346,433
2025	2025	REGENTS OF THE UNIVERSITY OF CALIFORNIA AT RIVERSIDE	200 UNIVERSTY OFC BUILDING	RIVERSIDE	CA	92521	RIVERSIDE	USA	Biomedical Research and Research Training	003	2	8/15/2025	NON-COMPETING CONTINUATION	$0
2025	2024	REGENTS OF THE UNIVERSITY OF CALIFORNIA AT RIVERSIDE	200 UNIVERSTY OFC BUILDING	RIVERSIDE	CA	92521	RIVERSIDE	USA	Biomedical Research and Research Training	000	1	11/22/2024	NEW	$0
														Subtotal = $384,925

Issue Date FY: 2024 ( Subtotal = $385,266 )
2024	2024	REGENTS OF THE UNIVERSITY OF CALIFORNIA AT RIVERSIDE	200 UNIVERSTY OFC BUILDING	RIVERSIDE	CA	92521	RIVERSIDE	USA	Biomedical Research and Research Training	000	1	3/19/2024	NEW	$385,266
														Subtotal = $385,266

Grand Total All Awards = $1,116,303

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Molecular genetics of signaling lipids

Award Number: R35GM153331

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 04/01/2024

PERIOD OF PERFORMANCE END DATE: 01/31/2029

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