Thursday, February 19, 2026 2/19/2026

Novel platforms for the discovery of bioactive small molecules

Award Number: R35GM151875
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 02/01/2024
PERIOD OF PERFORMANCE END DATE: 01/31/2029

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Novel platforms for the discovery of bioactive small molecules - Project Summary DNA-encoded library (DEL) technology has revolutionized the discovery of protein- binding small molecules. We have developed a novel variant of this technology in which the libraries are synthesized on tiny, hydrophilic beads using solid-phase synthesis techniques and screened by incubation with fluorescently labeled, soluble proteins. This platform will be employed to discover a plethora of new ligands for the proteasome and other proteins involved in the Ubiquitin Proteasome System (UPS). They will serve as probe molecules and drug leads for manipulating the UPS, which is critical for maintaining protein homeostasis. An additional outcome of this work will be the development of a new class of degraders that delivers a target protein directly to the proteasome without the requirement for target Ubiquitylation. Finally, a nascent system that allows screening DELs in cell-based assays will be optimized and utilized to discover proteasome activators that can be used to test models of UPS dysfunction as a root cause of aging and various degenerative diseases.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $565,112 )
2026	2026	UNIVERSITY OF FLORIDA	1523 UNION RD RM 207	GAINESVILLE	FL	32611	ALACHUA	USA	Biomedical Research and Research Training	000	3	1/14/2026	NON-COMPETING CONTINUATION	$565,112
														Subtotal = $565,112

Issue Date FY: 2025 ( Subtotal = $627,902 )
2025	2025	UNIVERSITY OF FLORIDA	1523 UNION RD RM 207	GAINESVILLE	FL	32611	ALACHUA	USA	Biomedical Research and Research Training	002	2	8/8/2025	NON-COMPETING CONTINUATION	$62,790
2025	2025	UNIVERSITY OF FLORIDA	1523 UNION RD RM 207	GAINESVILLE	FL	32611	ALACHUA	USA	Biomedical Research and Research Training	001	2	1/16/2025	NON-COMPETING CONTINUATION	$565,112
2025	2024	UNIVERSITY OF FLORIDA	1523 UNION RD RM 207	GAINESVILLE	FL	32611	ALACHUA	USA	Biomedical Research and Research Training	000	1	11/14/2024	NEW	$0
														Subtotal = $627,902

Issue Date FY: 2024 ( Subtotal = $731,551 )
2024	2024	UNIVERSITY OF FLORIDA	1523 UNION RD RM 207	GAINESVILLE	FL	32611	ALACHUA	USA	Biomedical Research and Research Training	000	1	1/23/2024	NEW	$731,551
														Subtotal = $731,551

Grand Total All Awards = $1,924,565

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Novel platforms for the discovery of bioactive small molecules

Award Number: R35GM151875

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 02/01/2024

PERIOD OF PERFORMANCE END DATE: 01/31/2029

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