Wednesday, February 18, 2026 2/18/2026

Structures and Mechanisms of Iron-Sulfur Proteins in Redox Control and Stress Response

Award Number: R35GM138157
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/01/2020
PERIOD OF PERFORMANCE END DATE: 07/31/2025

Group Awards By:

View Award Description

Structures and Mechanisms of Iron-Sulfur Proteins in Redox Control and Stress Response - PROJECT SUMMARY Iron-sulfur (Fe-S) clusters are ancient cofactors composed of multiple iron and sulfur atoms. Owing to the rich, tunable redox reactivity and selectivity of the cluster, Fe-S proteins play multifaced roles in redox control under both physiological and stress conditions, which is required for maintaining normal cellular functions and cell survival. Thus, Fe-S proteins are tightly linked to health and diseases (such as cancer, diabetes, and bacterial infection) in humans. The parent Maximizing Investigators’ Research Award (MIRA; R35 GM138157) project addresses the critical gaps in structural and mechanistic understanding of Fe-S proteins in the cellular control of redox homeostasis, including: i) the structural basis of redox reactivity and ligand selectivity in Fe-S clusters; ii) the mechanism by which the redox state and integrity of the Fe-S cluster allows these proteins to sense redox states and regulate transcription; iii) the structural biochemistry of Fe-S cluster biosynthesis and regulation; and iv) the role of non-proteinaceous thiols in modulating Fe-S cluster-mediated redox control. The research goals and approaches of the parent project are demonstrated in the three selected Fe-S protein-mediated mechanisms for redox control and stress response in mycobacteria: i) redox sensing and transcriptional regulation by the WhiB-like (Wbl) family proteins; ii) assembly, transfer, and repair of Fe-S clusters by the sulfur utilization factor (SUF) system; and iii) mycothiol in Fe-S cluster homeostasis. This diversity supplement request is to support the research training and career development of the pre-doctoral candidate Daisy Guiza Beltran. Daisy’s long-term goal is to establish a research career in molecular mechanisms of diseases. She has already gained skills in protein crystallography and protein biochemistry during her undergraduate research and the first three years of her Ph.D. thesis research in the PI’s group. The proposed research experience will expand Daisy’s expertise in structural biology and develop interdisciplinary skills in biomedical sciences. The training activities will further enhance her leadership and communication abilities and allow her to build a strong network of collaborations. The postdoctoral fellowship application will provide her with an opportunity to further her research skills and career development. Additionally, her commitment to promoting diversity and inclusion in the research environment will create a supportive and welcoming community for all, which will help her become a successful and impactful researcher.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $450,366 )
2024	2024	BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA	2200 VINE ST # 830861	LINCOLN	NE	68503	LANCASTER	USA	Biomedical Research and Research Training	001	5	7/26/2024	NON-COMPETING CONTINUATION	$366,206
2024	2024	BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA	2200 VINE ST # 830861	LINCOLN	NE	68503	LANCASTER	USA	Biomedical Research and Research Training	002	5	7/29/2024	SUPPLEMENT FOR EXPANSION	$65,848
2024	2024	BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA	2200 VINE ST	LINCOLN	NE	68503	LANCASTER	USA	Biomedical Research and Research Training	000	4	2/14/2024	SUPPLEMENT FOR EXPANSION	$18,312
														Subtotal = $450,366

Issue Date FY: 2023 ( Subtotal = $366,206 )
2023	2023	BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA	2200 VINE ST BOX 830861	LINCOLN	NE	68503	LANCASTER	USA	Biomedical Research and Research Training	000	4	7/10/2023	NON-COMPETING CONTINUATION	$366,206
														Subtotal = $366,206

Issue Date FY: 2022 ( Subtotal = $571,704 )
2022	2022	BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA	2200 VINE ST BOX 830861	LINCOLN	NE	68503	LANCASTER	USA	Biomedical Research and Research Training	000	2	5/25/2022	SUPPLEMENT FOR EXPANSION	$205,498
2022	2022	BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA	2200 VINE ST BOX 830861	LINCOLN	NE	68503	LANCASTER	USA	Biomedical Research and Research Training	001	3	7/1/2022	NON-COMPETING CONTINUATION	$366,206
														Subtotal = $571,704

Issue Date FY: 2021 ( Subtotal = $371,250 )
2021	2021	BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA	2200 VINE ST BOX 830861	LINCOLN	NE	68503	LANCASTER	USA	Biomedical Research and Research Training	000	2	7/19/2021	NON-COMPETING CONTINUATION	$371,250
														Subtotal = $371,250

Issue Date FY: 2020 ( Subtotal = $371,250 )
2020	2020	BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA	2200 VINE ST BOX 830861	LINCOLN	NE	68503	LANCASTER	USA	Biomedical Research and Research Training	000	1	8/5/2020	NEW	$371,250
														Subtotal = $371,250

Grand Total All Awards = $2,130,776

Top

All Categories

About

Search

Reports

Data Submission

Award Information

Structures and Mechanisms of Iron-Sulfur Proteins in Redox Control and Stress Response

Award Number: R35GM138157

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/01/2020

PERIOD OF PERFORMANCE END DATE: 07/31/2025

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer