Thursday, February 19, 2026 2/19/2026

Dynamics and evolution of translational regulation

Award Number: R35GM124976
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/14/2017
PERIOD OF PERFORMANCE END DATE: 08/31/2022

Group Awards By:

View Award Description

Dynamics and evolution of translational regulation - Project Summary Translating information from DNA to proteins is the most energetically expensive process a cell undertakes. The basic principles of translation are simple — free-floating ribosomes bind to mRNAs and translate the transcript one codon at a time, each of which is recognized by a corresponding tRNA. In recent years, our understanding of the molecular basis of translation has improved significantly. Advances in structural biology have provided a detailed view of how an individual ribosome rests at a particular codon on an mRNA, recognizes a tRNA, makes peptide bonds, and then physically translocates to the next codon. Many factors, such as patterns of codon usage, mRNA structures, transcript abundances, protein domain-architectures, lengths of genes and untranslated regions (UTRs), and initiation and elongation rates have all been shown to modulate protein production. However, there exist two critical gaps in our understanding of dynamics and evolution of translation. First, we lack a coherent view of how all the various factors involved in translation interact with each other to regulate the global pace of protein synthesis in a cell. Second, we know little about how regulation of protein synthesis changes over time during organismal evolution and speciation. To address these critical gaps, we will develop a synthetic modeling framework for transcription and translation, and parameterize it by generating high- throughput genomic datasets. We will employ this combined modeling/experimental approach to study the dynamics and regulation of protein synthesis in a panel of model organisms and evolving populations. In the long-term, this hybrid approach will allow us to study how a cell modulates translation in different contexts, including viral infections and systemic diseases such as cancer. This framework will be particularly useful for elucidating the mechanisms of diseases that arise from synonymous mutations leading to opportunities for development of therapeutic interventions to modify protein synthesis in a targeted manner.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2023 ( Subtotal = -$9,602 )
2023	2021	RUTGERS, THE STATE UNIVERSITY	3 RUTGERS PLZ	NEW BRUNSWICK	NJ	08901	MIDDLESEX	USA	Biomedical Research and Research Training	000	5	7/20/2023	NON-COMPETING CONTINUATION	-$9,602
														Subtotal = -$9,602

Issue Date FY: 2021 ( Subtotal = $381,022 )
2021	2021	RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY	3 RUTGERS PLZA	NEW BRUNSWICK	NJ	08901	MIDDLESEX	USA	Biomedical Research and Research Training	000	5	9/1/2021	NON-COMPETING CONTINUATION	$381,022
														Subtotal = $381,022

Issue Date FY: 2020 ( Subtotal = $381,022 )
2020	2020	RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY	3 RUTGERS PLZA	NEW BRUNSWICK	NJ	08901	MIDDLESEX	USA	Biomedical Research and Research Training	000	4	8/5/2020	NON-COMPETING CONTINUATION	$381,022
														Subtotal = $381,022

Issue Date FY: 2019 ( Subtotal = $381,022 )
2019	2019	RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY	3 RUTGERS PLZA	NEW BRUNSWICK	NJ	08901	MIDDLESEX	USA	Biomedical Research and Research Training	000	3	8/20/2019	NON-COMPETING CONTINUATION	$381,022
														Subtotal = $381,022

Issue Date FY: 2018 ( Subtotal = $381,022 )
2018	2018	RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY	3 RUTGERS PLZA	NEW BRUNSWICK	NJ	08901	MIDDLESEX	USA	Biomedical Research and Research Training	000	2	8/31/2018	NON-COMPETING CONTINUATION	$381,022
														Subtotal = $381,022

Issue Date FY: 2017 ( Subtotal = $381,022 )
2017	2017	RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY	3 RUTGERS PLZA	NEW BRUNSWICK	NJ	08901	MIDDLESEX	USA	Biomedical Research and Research Training	000	1	9/14/2017	NEW	$381,022
														Subtotal = $381,022

Grand Total All Awards = $1,895,508

Top

All Categories

About

Search

Reports

Data Submission

Award Information

Dynamics and evolution of translational regulation

Award Number: R35GM124976

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/14/2017

PERIOD OF PERFORMANCE END DATE: 08/31/2022

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer