Wednesday, February 18, 2026 2/18/2026

U.S. Deprescribing Research Network

Award Number: R24AG064025
ORGANIZATION: NATIONAL INSTITUTE ON AGING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/01/2019
PERIOD OF PERFORMANCE END DATE: 07/31/2026

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U.S. Deprescribing Research Network - PROJECT SUMMARY / ABSTRACT Deprescribing - the structured process of stopping unnecessary, potentially harmful, or goal-discordant medications in a safe, effective, and patient-centered manner – holds great promise for improving the health and well-being of older adults. Yet, research on deprescribing is fairly new, and much important work remains to be done. To address this gap, we propose to establish a deprescribing research network that will catalyze impactful research on deprescribing and build an interdisciplinary community of investigators working in this field. We will achieve this using 2 complementary approaches. First, we will establish a series of cores focused on Investigator Development, Stakeholder Engagement, Data and Resources, and Pilot and Exploratory Studies, and a Leadership and Administration Core that will oversee the full range of network activities. These cores will provide services and supports around learning, collaboration, investigator development, and pilot funding. These activities will enhance investigators' abilities to conduct high-quality, interdisciplinary, and stakeholder-informed research in deprescribing, and to compete successfully for future funding. Second, we will convene a series of special projects, organized into 4 Working Groups. These projects will use a combination of original research and consensus processes to develop new science and infrastructure in areas that are critical for advancing deprescribing research for older adults. Each of these activities will focus on older adults, particularly those with multiple chronic conditions and other sources of vulnerability, and the network will be firmly rooted in the principles of aging research and geriatrics. Consistent with the above goals, we have 6 specific aims. They are: (1) To develop a national community of investigators interested in deprescribing and to support mutual learning and opportunities for collaboration that will expand the quality, quantity, and translational impact of deprescribing research; (2) To create a coordinated network of research sites that will generate science, address logistical and safety challenges, and develop infrastructure to conduct clinical studies on deprescribing; (3) To develop and disseminate resources to help investigators overcome common challenges in deprescribing research and maximize the scientific validity and impact of scholarship in this area; (4) To support innovative pilot studies that address high-priority topics in deprescribing and will catalyze future investigator development and larger-scale projects; (5) To engage a broad range of stakeholders to maximize the relevance, sustainability, and dissemination potential of research on deprescribing; and (6) To disseminate the work and findings of the network to a broad range of external stakeholders and coordinate our efforts with other organizations and research networks.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $0 )
2026	2023	NORTHERN CALIFORNIA INSTITUTE FOR RESEARCH AND EDUCATION, INC.	4150 CLEMENT ST # 151	SAN FRANCISCO	CA	94121	SAN FRANCISCO	USA	Aging Research	000	5	11/21/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2024 ( Subtotal = $0 )
2024	2023	NORTHERN CALIFORNIA INSTITUTE FOR RESEARCH AND EDUCATION, INC.	4150 CLEMENT ST # 151	SAN FRANCISCO	CA	94121	SAN FRANCISCO	USA	Aging Research	000	5	1/26/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2023 ( Subtotal = $1,853,001 )
2023	2023	NORTHERN CALIFORNIA INSTITUTE FOR RESEARCH AND EDUCATION, INC.	4150 CLEMENT ST 151 NC	SAN FRANCISCO	CA	94121	SAN FRANCISCO	USA	Aging Research	001	5	8/15/2023	NON-COMPETING CONTINUATION	$1,507,522
2023	2023	NORTHERN CALIFORNIA INSTITUTE FOR RESEARCH AND EDUCATION, INC.	4150 CLEMENT ST 151 NC	SAN FRANCISCO	CA	94121	SAN FRANCISCO	USA	Aging Research	000	4	6/1/2023	SUPPLEMENT FOR EXPANSION	$345,479
2023	2023	NORTHERN CALIFORNIA INSTITUTE FOR RESEARCH AND EDUCATION, INC.	4150 CLEMENT ST 151 NC	SAN FRANCISCO	CA	94121	SAN FRANCISCO	USA	Aging Research	002	5	9/20/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,853,001

Issue Date FY: 2022 ( Subtotal = $2,737,950 )
2022	2022	NORTHERN CALIFORNIA INSTITUTE FOR RESEARCH AND EDUCATION, INC.	4150 CLEMENT ST 151 NC	SAN FRANCISCO	CA	94121	SAN FRANCISCO	USA	Aging Research	001	3	6/14/2022	SUPPLEMENT FOR EXPANSION	$0
2022	2022	NORTHERN CALIFORNIA INSTITUTE FOR RESEARCH AND EDUCATION, INC.	4150 CLEMENT ST 151 NC	SAN FRANCISCO	CA	94121	SAN FRANCISCO	USA	Aging Research	000	3	6/6/2022	SUPPLEMENT FOR EXPANSION	$334,771
2022	2022	NORTHERN CALIFORNIA INSTITUTE FOR RESEARCH AND EDUCATION, INC.	4150 CLEMENT ST 151 NC	SAN FRANCISCO	CA	94121	SAN FRANCISCO	USA	Aging Research	003	4	9/15/2022	SUPPLEMENT FOR EXPANSION	$900,400
2022	2022	NORTHERN CALIFORNIA INSTITUTE FOR RESEARCH AND EDUCATION, INC.	4150 CLEMENT ST 151 NC	SAN FRANCISCO	CA	94121	SAN FRANCISCO	USA	Aging Research	002	4	8/31/2022	NON-COMPETING CONTINUATION	$1,502,779
														Subtotal = $2,737,950

Issue Date FY: 2021 ( Subtotal = $2,037,190 )
2021	2021	NORTHERN CALIFORNIA INSTITUTE FOR RESEARCH AND EDUCATION, INC.	4150 CLEMENT ST 151 NC	SAN FRANCISCO	CA	94121	SAN FRANCISCO	USA	Aging Research	001	2	4/13/2021	SUPPLEMENT FOR EXPANSION	$0
2021	2021	NORTHERN CALIFORNIA INSTITUTE FOR RESEARCH AND EDUCATION, INC.	4150 CLEMENT ST 151 NC	SAN FRANCISCO	CA	94121	SAN FRANCISCO	USA	Aging Research	004	3	8/26/2021	NON-COMPETING CONTINUATION	$1,524,556
2021	2021	NORTHERN CALIFORNIA INSTITUTE FOR RESEARCH AND EDUCATION, INC.	4150 CLEMENT ST 151 NC	SAN FRANCISCO	CA	94121	SAN FRANCISCO	USA	Aging Research	002	2	4/26/2021	SUPPLEMENT FOR EXPANSION	$274,268
2021	2021	NORTHERN CALIFORNIA INSTITUTE FOR RESEARCH AND EDUCATION, INC.	4150 CLEMENT ST 151 NC	SAN FRANCISCO	CA	94121	SAN FRANCISCO	USA	Aging Research	000	2	4/9/2021	SUPPLEMENT FOR EXPANSION	$238,366
2021	2021	NORTHERN CALIFORNIA INSTITUTE FOR RESEARCH AND EDUCATION, INC.	4150 CLEMENT ST 151 NC	SAN FRANCISCO	CA	94121	SAN FRANCISCO	USA	Aging Research	003	2	4/27/2021	SUPPLEMENT FOR EXPANSION	$0
														Subtotal = $2,037,190

Issue Date FY: 2020 ( Subtotal = $1,544,614 )
2020	2020	NORTHERN CALIFORNIA INSTITUTE FOR RESEARCH AND EDUCATION, INC.	4150 CLEMENT ST 151 NC	SAN FRANCISCO	CA	94121	SAN FRANCISCO	USA	Aging Research	000	2	6/25/2020	NON-COMPETING CONTINUATION	$1,544,614
														Subtotal = $1,544,614

Issue Date FY: 2019 ( Subtotal = $1,694,751 )
2019	2019	NORTHERN CALIFORNIA INSTITUTE FOR RESEARCH AND EDUCATION, INC.	4150 CLEMENT ST 151 NC	SAN FRANCISCO	CA	94121	SAN FRANCISCO	USA	Aging Research	001	1	8/3/2019	NEW	$0
2019	2019	NORTHERN CALIFORNIA INSTITUTE FOR RESEARCH AND EDUCATION, INC.	4150 CLEMENT ST 151 NC	SAN FRANCISCO	CA	94121	SAN FRANCISCO	USA	Aging Research	000	1	8/1/2019	NEW	$1,694,751
														Subtotal = $1,694,751

Grand Total All Awards = $9,867,506

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U.S. Deprescribing Research Network

Award Number: R24AG064025

ORGANIZATION: NATIONAL INSTITUTE ON AGING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/01/2019

PERIOD OF PERFORMANCE END DATE: 07/31/2026

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