Enhanced intra-arterial drug delivery to the brain after blood brain barrier opening: comparison between osmotic and MRI-guided focused ultrasound opening techniques - Project Summary
Intra-arterial chemotherapy (IAC) converts systemic chemotherapy into a targeted therapeutic strategy
that has revolutionized retinoblastoma treatment. For decades, the IAC approach has attempted to similarly
transform brain cancer treatment; however, despite high hopes and many recognized advantages, IAC
outcomes proved highly variable, if not outright discouraging. Over the last decade, our group has focused on
identifying and addressing the impediments to effective IAC for brain tumors. Spatial image-guided control of
chemotherapeutic perfusion throughout the entire tumor and manipulation of the blood brain barrier (BBB) with
high spatial and temporal precision are fundamental challenges that we will to continue to address in this
proposal. Our approach with IAC is particularly relevant to brainstem tumors and other highly aggressive,
unresponsive brain tumors, for which surgery, radiotherapy, stereotactic drug delivery, and systemic
chemotherapy, have failed to show an overall survival benefit. Most tumors have regions of BBB integrity and,
in some gliomas, such as diffuse intrinsic pontine glioma (DIPG), the BBB is predominantly intact. The BBB,
which effectively blocks nearly all therapeutic agents to brain tumors, represents a formidable challenge, and in
order to fully exploit the potential of IAC, it must be performed in conjunction with BBB opening (BBBO).
Several methods of BBBO have been developed and two dominant techniques represent compelling
adjuncts for enhancing IAC efficacy. Osmotic BBB opening (OBBBO) via intra-arterial (IA) mannitol is used in
clinical protocols that have remained essentially unchanged since the late 1970s. Inconsistent results and
imprecise BBBO have hindered the widespread adoption of this method, which was performed solely under x-
ray guidance. We have previously demonstrated that OBBBO and IA drug delivery under MRI guidance is
essential, as it allows one to predict, adjust, and visualize BBBO in real-time. Precise control of the OBBBO
territory, however, may be challenging, reflecting the brain’s complex and dynamic angioarchitecture.
MRI-guided focused ultrasound (MRgFUS) has emerged as a new technology capable of BBBO in a
highly spatially precise manner, yet the utility of and its full therapeutic potential when used with IAC remains
uninvestigated. We hypothesize that IAC after MRgFUS BBBO is a safe and efficacious technique with more
consistent and effective drug delivery to the targeted brain area vs. IAC after mannitol mediated OBBBO.
The absence of effective treatment options for brainstem tumors and other highly aggressive,
unresponsive CNS tumors promotes the use of novel multimodality methods to enhance drug delivery to the
brain. We will address in a head-to-head comparison of MRgFUS vs. osmotic BBBO whether MRgFUS is
comparable or superior to the established osmotic technique in regards to safety, tolerability, and efficacy of
IAC after BBBO.
