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Harnessing biomarker and phenotypic diversity among adolescents and women with endometriosis to advance personalized medicine for diagnosis and pain remediation

Award Number: R21HD096358
ORGANIZATION: NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 05/01/2019
PERIOD OF PERFORMANCE END DATE: 04/30/2022

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Harnessing biomarker and phenotypic diversity among adolescents and women with endometriosis to advance personalized medicine for diagnosis and pain remediation - Project Summary/Abstract Endometriosis is a common disease among reproductive aged adolescents and women and can lead to debilitating pelvic pain, infertility, reduced quality of life and significant health care costs. Currently laparoscopic surgery is the only means for providing a definitive diagnosis of endometriosis. The average delay to diagnosis from symptom onset is 7 years, potentially leading to unchecked endometriotic lesion progression and increased risk and severity of morbidity later in adulthood. While numerous studies have investigated non- invasive screening tests for diagnosing endometriosis, none have proven to have sufficient specificity and/or sensitivity to replace laparoscopic surgery. Further, once an adolescent or woman has been diagnosed with endometriosis she often faces a struggle to find the most effective treatment modality to relieve endometriosis- related symptoms. While the revised American Society for Reproductive Medicine endometriosis staging and the Endometriosis Fertility Index have been used to predict prognosis after endometriosis diagnosis; neither is specific to predicting if adolescents and women will experience pain remediation. Additionally, a subset of endometriosis patients will develop central sensitization leading to treatment refractory chronic pelvic pain. The lack of discovery for a non-invasive screening test for endometriosis diagnosis and for monitoring disease progression may be due to considering endometriosis as a single entity and not including the full heterogeneity in symptom profiles and patient characteristics to assess diagnosis and pain remediation after treatment. Our proposal fills this scientific gap by (1) investigating a non-invasive diagnostic for endometriosis combining patient symptoms and characteristics with inflammatory, oxidative stress and central sensitization biomarkers; (2) assessing changes in inflammatory, oxidative stress and central sensitization biomarkers before and after surgery; and (3) determining the optimal set of patient symptoms and characteristics in addition to inflammatory, oxidative stress and central sensitization biomarkers to advance personalized treatment selection. We will assess inflammatory and oxidative stress biomarkers as an aberrant immune response and increased oxidative stress have been implicated in endometriosis etiology and progression. Collectively, these aims have the potential to advance our understanding of phenotypic diversity among adolescents and women with endometriosis; diversity that will be the foundation for successful personalized, precision medicine to shorten diagnostic delay and maximize pain remediation. Success will reduce health care costs and increase long-term health and quality of life for adolescents and women with endometriosis.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2023 ( Subtotal = -$18,120 )
2023	2020	MICHIGAN STATE UNIVERSITY	426 AUDITORIUM RD RM 2	EAST LANSING	MI	48824	INGHAM	USA	Child Health and Human Development Extramural Research	002	2	6/21/2023	NON-COMPETING CONTINUATION	$18,120
2023	2020	MICHIGAN STATE UNIVERSITY	426 AUDITORIUM RD RM 2	EAST LANSING	MI	48824	INGHAM	USA	Child Health and Human Development Extramural Research	001	2	5/15/2023	NON-COMPETING CONTINUATION	-$18,120
2023	2020	MICHIGAN STATE UNIVERSITY	426 AUDITORIUM RD RM 2	EAST LANSING	MI	48824	INGHAM	USA	Child Health and Human Development Extramural Research	000	2	5/3/2023	NON-COMPETING CONTINUATION	-$18,120
														Subtotal = -$18,120

Issue Date FY: 2020 ( Subtotal = $213,974 )
2020	2020	MICHIGAN STATE UNIVERSITY	426 AUDITORIUM RD RM 2	EAST LANSING	MI	48824	INGHAM	USA	Child Health and Human Development Extramural Research	000	2	5/15/2020	NON-COMPETING CONTINUATION	$213,974
														Subtotal = $213,974

Issue Date FY: 2019 ( Subtotal = $285,012 )
2019	2019	MICHIGAN STATE UNIVERSITY	426 AUDITORIUM RD RM 2	EAST LANSING	MI	48824	INGHAM	USA	Child Health and Human Development Extramural Research	000	1	4/25/2019	NEW	$285,012
														Subtotal = $285,012

Grand Total All Awards = $480,866

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Harnessing biomarker and phenotypic diversity among adolescents and women with endometriosis to advance personalized medicine for diagnosis and pain remediation

Award Number: R21HD096358

ORGANIZATION: NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 05/01/2019

PERIOD OF PERFORMANCE END DATE: 04/30/2022

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