Wednesday, May 8, 2024 5/8/2024

Self-collimating Single Photon Emission Breast Tomography System with Three-Dimensional Sparse Position-Sensitive Detectors

Award Number: R21EB032993
ORGANIZATION: NATIONAL INSTITUTE Of BIOMEDICAL IMAGING & BIOENGINEERING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Project Summary Breast cancer is the most diagnosed cancer among American women and is projected to become the most common cancer globally in 2021. To minimize the morbidity and mortality of this disease, it is imperative to develop improved testing methods to enable more effective treatment. The proposed work is to develop a new Single Photon Emission Breast Tomography (SPEBT) scanner to carry out radionuclide tracer based molecular breast imaging which has demonstrated clear advantages in the early detection of cancer malignancy in clinical trials, because of its 1) capability to detect pathological functional changes which take place before morphological anatomical developments and 2) up-to pico-mole sensitivity, which stems from collecting signals directly at the molecular level. The SPEBT system will have a system detection efficiency of 3.5×10-2 and spatial resolution of 2-mm, which are 50 and 2 times better than that of state-of-the-art dedicated single photon emission molecular breast imaging cameras, respectively. The significant imaging performance improvement will ease existing concerns on radiation dose and the inability to detect tumors of less than 5-mm in size — issues that have prevented molecular breast imaging from playing a much more prominent role in clinical breast cancer diagnosis and screening. The enabling concept behind the high-performance of the SPEBT is a novel detector architecture, a three-dimensional sparse position-sensitive detector, that achieves collimation largely by and for itself, which is termed self-collimation. This architecture allows the SPEBT to achieve both high-resolution and high detection efficiency. This is a critical conceptual breakaway from the mechanical-collimator-based detector structure that single-photon emission imaging technology relies on for years — mechanical collimator mandates an inverse interdependency between the resolution and detection efficiency, therefore, sets a hard ceiling for overall imaging performance. The proposed approach opens up a broad path to better imaging performance for breast and other imaging applications. The proposed project is to design and evaluate a SPEBT system with optimized configurations and develop and test a proof-of-concept SPEBT prototype.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $144,750 )
2024	2024	RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE	520 LEE ENTRANCE STE 211	AMHERST	NY	14228	ERIE	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	3	2/28/2024	NON-COMPETING CONTINUATION	$144,750
														Subtotal = $144,750

Issue Date FY: 2023 ( Subtotal = $200,416 )
2023	2023	RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE	520 LEE ENTRANCE STE 211	AMHERST	NY	14228	ERIE	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	2	3/8/2023	NON-COMPETING CONTINUATION	$200,416
														Subtotal = $200,416

Issue Date FY: 2022 ( Subtotal = $249,903 )
2022	2022	RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE	520 LEE ENTRANCE STE 211	AMHERST	NY	14228	ERIE	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	1	5/20/2022	NEW	$249,903
														Subtotal = $249,903

Grand Total All Awards = $595,069

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Self-collimating Single Photon Emission Breast Tomography System with Three-Dimensional Sparse Position-Sensitive Detectors

Award Number: R21EB032993

ORGANIZATION: NATIONAL INSTITUTE Of BIOMEDICAL IMAGING & BIOENGINEERING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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