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CREVICULAR FLUID CONTENT DURING EARLY WOUND HEALING- IMPLANT VERSUS TOOTH

Award Number: R21DE018718
ORGANIZATION: NATIONAL INSTITUTE OF DENTAL AND CRANIOFACIAL RESEARCH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 03/15/2009
PERIOD OF PERFORMANCE END DATE: 02/28/2014

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CREVICULAR FLUID CONTENT DURING EARLY WOUND HEALING- IMPLANT VERSUS TOOTH - DESCRIPTION (provided by applicant): One stage (non-submerged) implant placement is a surgical procedure with clinically acceptable treatment outcomes. Among other advantages, it allows evaluation of early phases of wound healing around dental implants. A major difference between periodontal and peri-implant wounds is the lack of a periodontal attachment apparatus and related blood supply in the latter. This difference may be reflected in the content of gingival crevicular fluid (GCF), a transudate originated from serum. This study hypothesizes that host originated factors of newly forming peri-implant crevice fluid (PICF) are different than adjacent GCF during early wound healing. The ultimate goal of this study is to explore possible differences in PICF and adjacent GCF content following surgery. PICF and adjacent GCF in newly forming crevices will be compared for wound healing markers specific for inflammatory process and tissue degradation/remodeling (e.g. VEGF, TGF-b, IL-6, IL-10, MMP-8, MMP-9, TIMP-1, TIMP-2, TNF-a, IL-1b, bone alkaline phosphatase and osteocalcin) to determine: a) anticipated differences in early wound healing responses at soft and/or hard tissue levels around dental implants placed at non-grafted, naturally healed sites compared to natural root; b) possible association between local levels of markers and implant stability during early healing. If these studies confirm our hypothesis, we plan to design clinical studies to test new therapeutic approaches for better post-operative care and control in surgical treatment outcome following dental implant surgery. We also plan to perform longterm prospective studies to determine the effect of these early changes observed during healing on longterm implant success. PUBLIC HEALTH RELEVANCE: The demand for dental implant services, as an alternative to conventional dental restorations, has dramatically increased during last two decades. Although reported clinical success is equivalent for these treatment modalities, there is a significant need to identify risk factors associated with healing complications and poor treatment outcomes following dental implant placement. This exploratory clinical study aims to determine possible differences in peri-implant crevicular fluid and adjacent gingival crevicular fluid content following one-stage dental implant placement surgery. This model will allow investigation of early stages of wound healing prior to soft tissue seal maturation without altering actual treatment protocol.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2013 ( Subtotal = $0 )
2013	2010	OHIO STATE UNIVERSITY, RESEARCH FOUNDATION	1960 KENNY ROAD	COLUMBUS	OH	43210	FRANKLIN	USA	Oral Diseases and Disorders Research	000	2	1/24/2013	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2012 ( Subtotal = $0 )
2012	2010	OHIO STATE UNIVERSITY, RESEARCH FOUNDATION	1960 KENNY ROAD	COLUMBUS	OH	43210	FRANKLIN	USA	Oral Diseases and Disorders Research	000	2	1/11/2012	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2010 ( Subtotal = $148,500 )
2010	2010	OHIO STATE UNIVERSITY, RESEARCH FOUNDATION	1960 KENNY ROAD	COLUMBUS	OH	43210	FRANKLIN	USA	Oral Diseases and Disorders Research	000	2	2/18/2010	NON-COMPETING CONTINUATION	$148,500
														Subtotal = $148,500

Issue Date FY: 2009 ( Subtotal = $225,000 )
2009	2009	OHIO STATE UNIVERSITY, RESEARCH FOUNDATION	1960 KENNY ROAD	COLUMBUS	OH	43210	FRANKLIN	USA	Oral Diseases and Disorders Research	000	1	3/11/2009	NEW	$225,000
														Subtotal = $225,000

Grand Total All Awards = $373,500

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CREVICULAR FLUID CONTENT DURING EARLY WOUND HEALING- IMPLANT VERSUS TOOTH

Award Number: R21DE018718

ORGANIZATION: NATIONAL INSTITUTE OF DENTAL AND CRANIOFACIAL RESEARCH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 03/15/2009

PERIOD OF PERFORMANCE END DATE: 02/28/2014

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