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Set for Life: Long-term Effects of Inactivity During Growth on Musculoskeletal Form and Locomotor Function

Award Number: R21AR071588
ORGANIZATION: NATIONAL INSTITUTE OF ARTHRITIS & MUSCULOSKELETAL & SKIN DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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PROJECT SUMMARY Physical inactivity is known to contribute to a broad array of health problems throughout the lifespan, but biomechanical factors that limit physical activity are poorly understood. The skeleton is known to adapt to its activity-dependent loading, and skeletal structure is especially plastic during growth. Studies of animal models have revealed differences in bone shape and joint structure between groups that are physically inactive and active during growth, but the post-growth consequences of these changes have not yet been examined. Preliminary experiments (N = 30) with a bipedal animal model (the guinea fowl Numida meleagris) have revealed differences between inactive and active animals that musculoskeletal computer models predict will compromise torque- and power-generating capacity in animals raised in inactivity. This diminished function may reduce locomotor performance and increase effort when inactive animals with suboptimal musculoskeletal structure struggle to move in an optimal fashion. The purpose of the work proposed in this R21 application is to determine the effects of growth-period inactivity upon not only musculoskeletal structure but also locomotor performance, both immediately post-growth and after a period of adult inactivity. This goal will be addressed using a rigorous approach that combines: (1) an experimental design in which guinea fowl are subjected to normal activity, general inactivity, and disuse that is focused upon a single muscle group and a single joint using botulinum toxin A, a neuromuscular blocking agent; and (2) musculoskeletal computer modeling to identify links between altered structure and reduced function. We will assess musculoskeletal structure and locomotor function immediately following growth (at 26 wks) and we will determine whether differences found after growth persist into an inactive adulthood (at 52 wks). If successful, this work will lead to better understanding of the consequences of inactivity during growth on locomotor function and will lead to novel interventions designed to minimize biomechanical barriers to activity and thus enhance lifelong health and mobility.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2021 ( Subtotal = $0 )
2021	2019	PENNSYLVANIA STATE UNIVERSITY, THE	201 OLD MAIN	UNIVERSITY PARK	PA	16802	CENTRE	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	2	8/27/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2019 ( Subtotal = $165,051 )
2019	2019	PENNSYLVANIA STATE UNIVERSITY, THE	201 OLD MAIN	UNIVERSITY PARK	PA	16802	CENTRE	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	2	4/24/2019	NON-COMPETING CONTINUATION	$165,051
														Subtotal = $165,051

Issue Date FY: 2018 ( Subtotal = $200,261 )
2018	2018	PENNSYLVANIA STATE UNIVERSITY, THE	201 OLD MAIN	UNIVERSITY PARK	PA	16802	CENTRE	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	1	5/1/2018	NEW	$200,261
														Subtotal = $200,261

Grand Total All Awards = $365,312

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Set for Life: Long-term Effects of Inactivity During Growth on Musculoskeletal Form and Locomotor Function

Award Number: R21AR071588

ORGANIZATION: NATIONAL INSTITUTE OF ARTHRITIS & MUSCULOSKELETAL & SKIN DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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