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Understanding the role of CsrA in Acinetobacter baumannii survival and infection

Award Number: R21AI159072
ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 03/22/2021
PERIOD OF PERFORMANCE END DATE: 02/29/2024

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Understanding the role of CsrA in Acinetobacter baumannii survival and infection - Abstract Acinetobacter baumannii is an opportunistic pathogen that causes serious infections which are very difficult to treat due to multidrug resistance. The majority of these infections occur in hospitalized, critically ill individuals, and spread through the hospital environment is a major concern for this pathogen. We developed a screen to identify genes that support the survival of A. baumannii on dry surfaces, since this ability likely facilitates A. baumannii’s spread. One of the genes we identified encodes the regulatory protein CsrA. This regulator is important for controlling metabolism and virulence in other bacterial species, and as we began to study the function of CsrA in A. baumannii, we found that it also appeared to be critical for host-associated growth. This has provided a great opportunity to discover novel genes and determinants involved in A. baumannii virulence and spread by further investigating the regulatory function of CsrA in this organism. The goals of this proposal are: 1) To determine the specific functions needed for host-associated growth by examining role of CsrA in controlling A. baumannii metabolism; and 2) To identify direct regulatory targets of CsrA in order to understand how it influences A. baumannii growth and environmental survival. The long-term objectives of this research are to identify potential targets for the development of new treatments for A. baumannii infections, and to gain a better understanding of the mechanisms through which A. baumannii persists in the nosocomial environment with the goal of developing new interventions to curb its spread in hospitals.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = -$1,305 )
2024	2022	EAST CAROLINA UNIVERSITY	1000 E 5TH ST	GREENVILLE	NC	27858	PITT	USA	Allergy and Infectious Diseases Research	000	2	9/16/2024	NON-COMPETING CONTINUATION	-$1,305
														Subtotal = -$1,305

Issue Date FY: 2022 ( Subtotal = $188,750 )
2022	2022	EAST CAROLINA UNIVERSITY	1000 E 5TH ST	GREENVILLE	NC	27858	PITT	USA	Allergy and Infectious Diseases Research	000	2	2/10/2022	NON-COMPETING CONTINUATION	$188,750
														Subtotal = $188,750

Issue Date FY: 2021 ( Subtotal = $226,500 )
2021	2021	EAST CAROLINA UNIVERSITY	1000 E 5TH ST	GREENVILLE	NC	27858	PITT	USA	Allergy and Infectious Diseases Research	000	1	3/19/2021	NEW	$226,500
														Subtotal = $226,500

Grand Total All Awards = $413,945

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Understanding the role of CsrA in Acinetobacter baumannii survival and infection

Award Number: R21AI159072

ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 03/22/2021

PERIOD OF PERFORMANCE END DATE: 02/29/2024

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