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Investigating the Impact of Novel Senescent Microglia in Alzheimer's Disease Progression

Award Number: R21AG087361
ORGANIZATION: NATIONAL INSTITUTE ON AGING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 04/15/2024
PERIOD OF PERFORMANCE END DATE: 03/31/2026

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Investigating the Impact of Novel Senescent Microglia in Alzheimer's Disease Progression - Title: Inves�ga�ng the Impact of Novel Senescent Microglia in Alzheimer's Disease Pathology Abstract: Alzheimer's Disease (AD) is a debilita�ng neurodegenera�ve disorder with a cri�cal need for improved therapeu�c strategies. One controversial component of AD progression is the role of microglia, the brain's immune cells. Recent research indicates a subpopula�on of these cells exhibi�ng senescence characteris�cs, raising the ques�on if these senescent microglia might contribute to AD progression through a senescence-associated secretory phenotype (SASP). Our proposal aims to elucidate the role of these cells in AD using a two-fold approach: deﬁning and characterizing these senescent microglia through proteomic, transcriptomic, and spa�al-omics proﬁling (Aim 1) and inves�ga�ng whether removing these senescent microglia can slow or delay AD progression (Aim 2). We plan to leverage a novel transgenic mouse model to selec�vely ablate newly iden�ﬁed senescent microglia and assess the subsequent impact on AD progression. If successful, these studies could oﬀer novel insight into AD pathology and iden�fy poten�al therapeu�c targets by focusing on the selec�ve elimina�on of senescent microglia.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $0 )
2026	2026	THE UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO	7703 FLOYD CURL DR	SAN ANTONIO	TX	78229	BEXAR	USA	Aging Research	001	2	1/21/2026	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$165,835
2026	2024	MAYO CLINIC	200 1ST ST SW	ROCHESTER	MN	55905	OLMSTED	USA	Aging Research	000	1	1/21/2026	NEW	-$165,835
														Subtotal = $0

Issue Date FY: 2024 ( Subtotal = $461,058 )
2024	2024	MAYO CLINIC	200 1ST ST SW	ROCHESTER	MN	55905	OLMSTED	USA	Aging Research	000	1	4/3/2024	NEW	$461,058
														Subtotal = $461,058

Grand Total All Awards = $461,058

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Investigating the Impact of Novel Senescent Microglia in Alzheimer's Disease Progression

Award Number: R21AG087361

ORGANIZATION: NATIONAL INSTITUTE ON AGING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 04/15/2024

PERIOD OF PERFORMANCE END DATE: 03/31/2026

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