Tuesday, May 14, 2024
5/14/2024
Title: Inves¿ga¿ng the Impact of Novel Senescent Microglia in Alzheimer's Disease Pathology Abstract: Alzheimer's Disease (AD) is a debilita¿ng neurodegenera¿ve disorder with a cri¿cal need for improved therapeu¿c strategies. One controversial component of AD progression is the role of microglia, the brain's immune cells. Recent research indicates a subpopula¿on of these cells exhibi¿ng senescence characteris¿cs, raising the ques¿on if these senescent microglia might contribute to AD progression through a senescence-associated secretory phenotype (SASP). Our proposal aims to elucidate the role of these cells in AD using a two-fold approach: de¿ning and characterizing these senescent microglia through proteomic, transcriptomic, and spa¿al-omics pro¿ling (Aim 1) and inves¿ga¿ng whether removing these senescent microglia can slow or delay AD progression (Aim 2). We plan to leverage a novel transgenic mouse model to selec¿vely ablate newly iden¿¿ed senescent microglia and assess the subsequent impact on AD progression. If successful, these studies could o¿er novel insight into AD pathology and iden¿fy poten¿al therapeu¿c targets by focusing on the selec¿ve elimina¿on of senescent microglia.
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