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Cerebellar repetitive transcranial magnetic stimulation (rTMS) for reduction of negative affect and treatment of alcohol use disorder

Award Number: R21AA026573
ORGANIZATION: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Abstract Alcohol use disorder (AUD) is a major cause of morbidity and mortality. More treatments are needed. Repetitive transcranial magnetic stimulation (rTMS) alters neuroplasticity and connectivity within the brain, is an FDA-approved treatment for major depressive disorder, and is being explored for the treatment of AUD. To date, however, an efficacious rTMS protocol for reduction of drinking and other important clinical outcomes in AUD have yet to be identified. Preliminary data indicates that the cerebellum may be an important treatment target for reduction of negative affect and downstream alcohol use in individuals with AUD. In particular, greater activation in cerebellum during a multisensory Stroop task is strongly correlated with both self-reported negative affect and alcohol use disorder severity. The overall aim of this study is to investigate the efficacy of inhibitory rTMS on self-reported negative affect and on activation in cerebellum during a multisensory Stroop task. Thirty-four treatment-seeking individuals with AUD will be recruited from local intensive outpatient treatment programs (IOPs), enrolled, randomized to active treatment or sham (blinded), and treated in 10 sessions over 2 weeks. To assess changes in brain function that result from treatment with rTMS, fMRI scans will be obtained at baseline and 2 weeks (baseline and 1 day following treatment completion). Our primary outcome measures will include self-reported negative affect, cerebellar activation during the Stroop task, and alcohol use outcomes. We hypothesize that reductions in negative affect and in BOLD signal will be greater in individuals on active compared to sham inhibitory rTMS. We also hypothesize that these reductions and active treatment will be related to better alcohol use outcomes (greater percent days abstinent, longer time to relapse). Findings will provide critical information about whether or not a larger clinical-trial investigating the efficacy of rTMS to the cerebellum for individuals with AUD is warranted.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $0 )
2024	2019	MIND RESEARCH NETWORK	1101 YALE BLVD NE	ALBUQUERQUE	NM	87106	BERNALILLO	USA	Alcohol Research Programs	000	2	11/7/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2022 ( Subtotal = $0 )
2022	2019	MIND RESEARCH NETWORK, THE	1101 YALE BLVD NE	ALBUQUERQUE	NM	87106	BERNALILLO	USA	Alcohol Research Programs	000	2	9/20/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2021 ( Subtotal = $0 )
2021	2019	MIND RESEARCH NETWORK, THE	1101 YALE BLVD NE	ALBUQUERQUE	NM	87106	BERNALILLO	USA	Alcohol Research Programs	000	2	11/25/2020	NON-COMPETING CONTINUATION	$0
2021	2019	MIND RESEARCH NETWORK, THE	1101 YALE BLVD NE	ALBUQUERQUE	NM	87106	BERNALILLO	USA	Alcohol Research Programs	001	2	8/31/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2019 ( Subtotal = $211,287 )
2019	2019	MIND RESEARCH NETWORK, THE	1101 YALE BLVD NE	ALBUQUERQUE	NM	87106	BERNALILLO	USA	Alcohol Research Programs	002	2	8/15/2019	NON-COMPETING CONTINUATION	$211,287
2019	2018	MIND RESEARCH NETWORK, THE	1101 YALE BLVD NE	ALBUQUERQUE	NM	87106	BERNALILLO	USA	Alcohol Research Programs	001	1	7/29/2019	NEW	$0
2019	2018	MIND RESEARCH NETWORK, THE	1101 YALE BLVD NE	ALBUQUERQUE	NM	87106	BERNALILLO	USA	Alcohol Research Programs	000	1	12/14/2018	NEW	$0
														Subtotal = $211,287

Issue Date FY: 2018 ( Subtotal = $256,562 )
2018	2018	MIND RESEARCH NETWORK, THE	1101 YALE BLVD NE	ALBUQUERQUE	NM	87106	BERNALILLO	USA	Alcohol Research Programs	000	1	9/17/2018	NEW	$256,562
														Subtotal = $256,562

Grand Total All Awards = $467,849

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Cerebellar repetitive transcranial magnetic stimulation (rTMS) for reduction of negative affect and treatment of alcohol use disorder

Award Number: R21AA026573

ORGANIZATION: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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