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Deposition of GBM invasion chip data to the Microphysiology Systems Database

Award Number: R15GM132877
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 05/01/2021
PERIOD OF PERFORMANCE END DATE: 04/30/2023

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Deposition of GBM invasion chip data to the Microphysiology Systems Database - PROJECT SUMMARY Glioblastoma (GBM) is the most prevalent and aggressive primary malignant brain tumor. The patient median survival is only fifteen months, due to its chemotactic invasion into adjacent brain tissues through the 3D-confined interstitial space. The underlying mechanism is still poorly understood, and effective therapies are still lacking. This is due to the lack of adequate research platforms. There is currently no representation of this disease in the Microphysiology System Database. Through an active NIH grant study, we recently developed a microfluidic device to study GBM invasion. This device recapitulates the native environment for individual cancer cell migration through interstitial space. We further integrated the chemical perfusion system that can manipulate the chemotactic environment (e.g., chemical composition, absolute concentration, concentration gradient) in real-time. So far, we have collected a significant amount of cell images and migration data, in various chemotactic conditions. We also collected the pharmacokinetic data for a potential inhibitory drug. To render the data to the general public, we propose to re-format and deposit them in the Microphysiology System Database. We will also expand the dataset by collecting the pharmacokinetic data from additional patient-derived cell lines. This study's outcome will significantly enhance our understanding of the GBM invasion and promote the discovery of more effective therapy.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = -$777 )
2024	2021	UTAH STATE UNIVERSITY	1000 OLD MAIN HL	LOGAN	UT	84322	CACHE	USA	Biomedical Research and Research Training	000	1	11/30/2023	SUPPLEMENT FOR EXPANSION	-$777
														Subtotal = -$777

Issue Date FY: 2022 ( Subtotal = $0 )
2022	2021	UTAH STATE UNIVERSITY	1000 OLD MAIN HILL	LOGAN	UT	84322	CACHE	USA	Biomedical Research and Research Training	001	1	5/18/2022	SUPPLEMENT FOR EXPANSION	$0
2022	2019	UTAH STATE UNIVERSITY	1000 OLD MAIN HILL	LOGAN	UT	84322	CACHE	USA	Biomedical Research and Research Training	000	1	5/17/2022	NEW	$0
														Subtotal = $0

Issue Date FY: 2021 ( Subtotal = $50,640 )
2021	2021	UTAH STATE UNIVERSITY	1000 OLD MAIN HILL	LOGAN	UT	84322	CACHE	USA	Biomedical Research and Research Training	000	1	9/13/2021	SUPPLEMENT FOR EXPANSION	$50,640
														Subtotal = $50,640

Issue Date FY: 2019 ( Subtotal = $435,000 )
2019	2019	UTAH STATE UNIVERSITY	1000 OLD MAIN HILL	LOGAN	UT	84322	CACHE	USA	Biomedical Research and Research Training	000	1	4/25/2019	NEW	$435,000
														Subtotal = $435,000

Grand Total All Awards = $484,863

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Deposition of GBM invasion chip data to the Microphysiology Systems Database

Award Number: R15GM132877

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 05/01/2021

PERIOD OF PERFORMANCE END DATE: 04/30/2023

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