Thursday, February 19, 2026 2/19/2026

Investigation of ssDNA binding proteins and protein-ssDNA interactions

Award Number: R15GM132846
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 04/01/2021
PERIOD OF PERFORMANCE END DATE: 03/31/2025

Group Awards By:

View Award Description

Investigation of ssDNA binding proteins and protein-ssDNA interactions - Project Summary/Abstract Molecular interactions between proteins and single-stranded DNA (ssDNA) play crucial roles in many fundamental biological processes, such as DNA replication, DNA recombination, DNA repair, gene regulation, and genome stability. ssDNA-binding proteins encompass various degrees of binding specificity, ranging from highly specific to non-specific. Despite the critical roles of protein-ssDNA interactions in essential biological processes, the investigation of protein-ssDNA interactions lags far behind other types of protein-nucleic acids interactions, such as protein-double stranded DNA (dsDNA) interaction. Currently there are no comprehensive, well-annotated resources for studying protein- ssDNA interactions. This proposal aims to investigate the mechanism of protein-ssDNA interactions by first constructing well-annotated protein-ssDNA data resources and by performing comparative analysis at two different levels. The first is to compare structural features between protein-ssDNA complexes with different binding specificity. The second is to investigate the similarity/differences between protein- ssDNA and protein-dsDNA complexes. In addition, we propose to predict novel ssDNA binding proteins from the unannotated protein sequences by combining structure-based protein threading methods and sequence-based machine learning approaches.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = -$113,754 )
2025	2021	UNIVERSITY OF NORTH CAROLINA AT CHARLOTTE	9201 UNIVERSITY CITY BLVD	CHARLOTTE	NC	28223	MECKLENBURG	USA	Biomedical Research and Research Training	000	1	7/17/2025	NEW	-$113,754
														Subtotal = -$113,754

Issue Date FY: 2024 ( Subtotal = $0 )
2024	2021	UNIVERSITY OF NORTH CAROLINA AT CHARLOTTE, THE	9201 UNIVERSITY CITY BLVD	CHARLOTTE	NC	28223	MECKLENBURG	USA	Biomedical Research and Research Training	000	1	2/29/2024	NEW	$0
														Subtotal = $0

Issue Date FY: 2021 ( Subtotal = $435,894 )
2021	2021	UNIVERSITY OF NORTH CAROLINA AT CHARLOTTE, THE	9201 UNIVERSITY CITY BLVD	CHARLOTTE	NC	28223	MECKLENBURG	USA	Biomedical Research and Research Training	000	1	3/25/2021	NEW	$435,894
														Subtotal = $435,894

Grand Total All Awards = $322,140

Top

All Categories

About

Search

Reports

Data Submission

Award Information

Investigation of ssDNA binding proteins and protein-ssDNA interactions

Award Number: R15GM132846

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 04/01/2021

PERIOD OF PERFORMANCE END DATE: 03/31/2025

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer