Wednesday, February 18, 2026 2/18/2026

R15 AREA: Optimizing allosteric modulation of noncoding regulatory RNA function

Award Number: R15GM132841
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 05/01/2019
PERIOD OF PERFORMANCE END DATE: 08/31/2026

Group Awards By:

View Award Description

R15 AREA: Optimizing allosteric modulation of noncoding regulatory RNA function - Project Summary Bacterial drug resistance is a significant global health threat that has turned once treatable bacterial infections (including Gram-positive infections) into deadly illnesses. To overcome this serious threat to human health, completely novel antibiotics are needed. The T-box riboswitch is a noncoding RNA that regulates the expression of essential genes in many Gram-positive bacteria (including pathogenic examples), thus making it a unique target for novel antibacterial agents. A key component of the T-box riboswitch regulatory mechanism involves tRNA binding to the highly conserved antiterminator RNA element--an excellent target for drug discovery. This project will explore the rational design of allosteric modulators of T-box antiterminator RNA function and compare their efficacy to that of competitive inhibitors. No therapeutic agents are currently known to specifically target the T-box riboswitch. This supplement request proposal seeks to replace a 14-year old microplate reader that is failing. Replacement of this essential piece of equipment will enable us to fulfill the specific aims of the parent award. The proposed research is unchanged from the parent award where we planned to use computational methods to design the next generation of compounds that inhibit T-box riboswitch function, then synthesize and test them in high throughput screening assays followed by characterization of RNA binding mode. Achievement of the proposed specific aims of the parent award will improve scientific knowledge by developing design strategies to identify inhibitors (including allosteric modulators) of RNA function and by exploring the most effective chemical space features of these small molecules. This information will be significant for antibacterial drug discovery targeting the T-box riboswitch and also for the still emerging broader field of targeting noncoding regulatory RNA in general for antibacterial, antiviral, anticancer and other drug discovery efforts. In the process, a team of primarily undergraduate students will gain first-hand experience working on an innovative drug discovery project that will inspire them to consider careers in biomedical research.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $89,716 )
2024	2024	OHIO UNIVERSITY	1 OHIO UNIVERSITY	ATHENS	OH	45701	ATHENS	USA	Biomedical Research and Research Training	000	2	5/9/2024	SUPPLEMENT FOR EXPANSION	$89,716
														Subtotal = $89,716

Issue Date FY: 2023 ( Subtotal = $453,000 )
2023	2023	OHIO UNIVERSITY	1 OHIO UNIVERSITY	ATHENS	OH	45701	ATHENS	USA	Biomedical Research and Research Training	000	2	9/8/2023	COMPETING CONTINUATION	$453,000
2023	2019	OHIO UNIVERSITY	1 OHIO UNIVERSITY	ATHENS	OH	45701	ATHENS	USA	Biomedical Research and Research Training	001	1	9/24/2023	NEW	$0
														Subtotal = $453,000

Issue Date FY: 2019 ( Subtotal = $453,000 )
2019	2019	OHIO UNIVERSITY	1 OHIO UNIVERSITY	ATHENS	OH	45701	ATHENS	USA	Biomedical Research and Research Training	000	1	4/16/2019	NEW	$453,000
														Subtotal = $453,000

Grand Total All Awards = $995,716

Top

All Categories

About

Search

Reports

Data Submission

Award Information

R15 AREA: Optimizing allosteric modulation of noncoding regulatory RNA function

Award Number: R15GM132841

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 05/01/2019

PERIOD OF PERFORMANCE END DATE: 08/31/2026

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer