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Temporal lobe epileptogenesis

Award Number: R01NS136433
ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 04/15/2024
PERIOD OF PERFORMANCE END DATE: 03/31/2029

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Temporal lobe epileptogenesis - Project Summary / Abstract Our ultimate goal is to discover causes of seizures in patients with temporal lobe epilepsy. The primary objective of the proposed project is to generate new data on reelin-positive interneurons in the dentate gyrus and test whether their loss is epileptogenic. The specific aims are to: Identify the type of reelin interneuron whose loss correlates with seizure frequency. Test whether loss of reelin interneurons in the dentate gyrus occurs in a large animal model of temporal lobe epilepsy. Test whether reelin-positive interneurons are total molecular layer cells. Measure the strength of synaptic output of reelin interneurons. And test whether loss of reelin causes seizures. To achieve these goals animal models will be evaluated: pilocarpine-treated rats and sea lions with naturally occurring temporal lobe epilepsy. Methods employed will include continuous telemetric video-EEG seizure monitoring, immunocytochemistry, stereology, whole cell recording in hippocampal slices, biocytin labeling, paired recording of unitary inhibitory postsynaptic currents, and prolonged focal brain infusion using mini-osmotic pumps.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $549,154 )
2025	2025	THE LELAND STANFORD JUNIOR UNIVERSITY	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	2	8/8/2025	NON-COMPETING CONTINUATION	$54,915
2025	2025	THE LELAND STANFORD JUNIOR UNIVERSITY	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	2	4/7/2025	NON-COMPETING CONTINUATION	$494,239
														Subtotal = $549,154

Issue Date FY: 2024 ( Subtotal = $563,879 )
2024	2024	THE LELAND STANFORD JUNIOR UNIVERSITY	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	1	4/8/2024	NEW	$563,879
														Subtotal = $563,879

Grand Total All Awards = $1,113,033

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Temporal lobe epileptogenesis

Award Number: R01NS136433

ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 04/15/2024

PERIOD OF PERFORMANCE END DATE: 03/31/2029

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