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Investigation of Pallidal Neurons in Motor Inhibition

Award Number: R01NS136123
ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 02/20/2024
PERIOD OF PERFORMANCE END DATE: 01/31/2029

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Investigation of Pallidal Neurons in Motor Inhibition - Project Summary The long-term goal of this project is to deepen our understanding of how the external globus pallidus (GPe) within the basal ganglia controls movement and how it goes awry in Parkinson’s disease (PD). Despite compelling evidence that the GPe plays a critical role in regulating motor activity, its neuronal composition has been poorly defined. As the neurons that encompass the GPe are heterogeneous, understanding how the activity of the GPe is regulated in behavioral and disease contexts has posed a challenge. Through a series of investigations during the last funding cycle, we surveyed the molecular landscape of the mouse GPe. By characterizing a number of driver and reporter lines, we have now established a near-complete neuron taxonomy of the GPe. Using the newly available genetic tools in conjunction with cell- and circuit-specific approaches, we began to understand how GPe neuron subtypes control full-body movements. In this application, we will examine the activity dynamics of GPe neuron subtypes and their regulation of their synaptic partners to clarify the mechanisms involved. These experiments will provide new information about how motor inhibition is produced by the GPe and the basal ganglia as a whole. Using a well-established chronic model of PD, we will provide unprecedented insights into how alterations in these processes underlie hypokinetic symptoms of PD. The yielded knowledge will not only inform the processes underlying motor (dys)function but will also help develop circuit interventions that target the hypokinetic symptoms of PD.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $527,248 )
2026	2026	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	2	1/31/2026	NON-COMPETING CONTINUATION	$527,248
														Subtotal = $527,248

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2024	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	1	3/14/2025	NEW	$0
														Subtotal = $0

Issue Date FY: 2024 ( Subtotal = $601,348 )
2024	2024	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	1	2/19/2024	NEW	$601,348
														Subtotal = $601,348

Grand Total All Awards = $1,128,596

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Investigation of Pallidal Neurons in Motor Inhibition

Award Number: R01NS136123

ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 02/20/2024

PERIOD OF PERFORMANCE END DATE: 01/31/2029

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