Wednesday, February 18, 2026 2/18/2026

Circuit level analysis of sleep-metabolism interactions

Award Number: R01NS131628
ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 01/08/2024
PERIOD OF PERFORMANCE END DATE: 12/31/2028

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Circuit level analysis of sleep-metabolism interactions - Proposal Summary Neural regulation of sleep, appetite and energy homeostasis is critical to an animal’s survival and under stringent evolutionary pressure. Despite the prevalence of disorders associated with metabolism and sleep, the neural and genetic processes that regulate interactions between these two systems is unclear. This proposal will investigate how genes and neurons modulate sleep in response to changes in metabolism. Flies, like mammals, potently modulate rest/activity cycles in accordance with their nutritional needs. Specifically, flies and mammals suppress sleep in response to food deprivation, presumably to initiate food-seeking behavior. Powerful genetics in the fruit fly allow for precise characterization of genes regulating behavioral and metabolic processes. We recently identified a single pair of neurons that express the neuropeptide Leucokinin and are required for sleep- metabolism interactions. This proposal will examine the neural signatures of food deprivation within these neurons, and how they are regulated by intrinsic and extrinsic cues associated with feeding state. We will combine single cell physiology and sequencing to define the molecular changes within these neurons associated with sleep and food deprivation. Finally, we will examine how the peripheral adipose tissue communicates energy stores to neurons in the brain that regulate sleep-metabolism interactions. Functional investigation of genes regulating sleep-metabolism interactions will provide the groundwork for understanding metabolic regulation of behavior and further our understanding of obesity, sleep disorders and diabetes.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $373,167 )
2026	2026	TEXAS A & M UNIVERSITY	400 HARVEY MITCHELL PKY S STE 300	COLLEGE STATION	TX	77845	BRAZOS	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	3	1/23/2026	NON-COMPETING CONTINUATION	$373,167
														Subtotal = $373,167

Issue Date FY: 2025 ( Subtotal = $371,765 )
2025	2025	TEXAS A & M UNIVERSITY	400 HARVEY MITCHELL PKY S STE 300	COLLEGE STATION	TX	77845	BRAZOS	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	2	12/12/2024	NON-COMPETING CONTINUATION	$371,765
														Subtotal = $371,765

Issue Date FY: 2024 ( Subtotal = $422,386 )
2024	2024	TEXAS A & M UNIVERSITY	400 HARVEY MITCHELL PKY S STE 300	COLLEGE STATION	TX	77845	BRAZOS	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	1	1/5/2024	NEW	$422,386
														Subtotal = $422,386

Grand Total All Awards = $1,167,318

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Circuit level analysis of sleep-metabolism interactions

Award Number: R01NS131628

ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 01/08/2024

PERIOD OF PERFORMANCE END DATE: 12/31/2028

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