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Development and Function of Sleep Circuits - Extramural Research Programs in the Neurosciences and Neurological Disorders

Award Number: R01NS112844
ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 04/01/2020
PERIOD OF PERFORMANCE END DATE: 03/31/2026

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Development and Function of Sleep Circuits - Extramural Research Programs in the Neurosciences and Neurological Disorders - We have little current understanding of the genetic and molecular mechanisms that link brain development and the proper regulation of sleep throughout life. Understanding these mechanisms is a longstanding challenge in sleep biology with great clinical relevance. Neurodevelopmental disorders including autism are prevalent and closely associated with sleep disturbances, but the underlying genetic and neuroanatomical mechanisms remain obscure. Our studies use the powerful Drosophila model system to characterize a conserved genetic pathway whose activity is required during neuronal development for the sleep regulation in adulthood. This pathway is composed of Insomniac (Inc), the Cullin-3 (Cul3) ubiquitin ligase, and their targets. Reduced activity of this pathway in the developing brain severely curtails the duration and consolidation of sleep in adulthood. Our findings suggest that this pathway has two distinct developmental functions that influence the structure and function of the mushroom body, a sleep regulatory center in the fly brain. In Aim 1 we will determine whether inc acts in neuroblasts to control the proliferation and number of sleep-regulatory neurons. We will also validate Inc substrates, including a target that may link Inc to asymmetric neuroblast division. In Aim 2, we will determine whether inc acts post-mitotically to regulate the structure and anatomy of sleep-regulatory neurons. In Aim 3, we will determine how inc affects the function of sleep-regulatory circuits. Because all of the genes under study are conserved and expressed in the mammalian brain, our studies may provide insight into mechanisms underlying normal sleep, sleep dysfunction, and various neurological disorders.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $383,791 )
2024	2024	RUTGERS, THE STATE UNIVERSITY	3 RUTGERS PLZ	NEW BRUNSWICK	NJ	08901	MIDDLESEX	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	5	4/12/2024	NON-COMPETING CONTINUATION	$27,696
2024	2024	RUTGERS, THE STATE UNIVERSITY	3 RUTGERS PLZ	NEW BRUNSWICK	NJ	08901	MIDDLESEX	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	5	3/11/2024	NON-COMPETING CONTINUATION	$356,095
														Subtotal = $383,791

Issue Date FY: 2023 ( Subtotal = $395,660 )
2023	2023	RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY	3 RUTGERS PLZA	NEW BRUNSWICK	NJ	08901	MIDDLESEX	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	4	4/27/2023	NON-COMPETING CONTINUATION	$395,660
														Subtotal = $395,660

Issue Date FY: 2022 ( Subtotal = $398,251 )
2022	2022	RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY	3 RUTGERS PLZA	NEW BRUNSWICK	NJ	08901	MIDDLESEX	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	003	3	4/29/2022	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$425,443
2022	2022	RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY	3 RUTGERS PLZA	NEW BRUNSWICK	NJ	08901	MIDDLESEX	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	3	2/25/2022	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$398,251
2022	2021	NEW YORK UNIVERSITY	550 1ST AVE	NEW YORK	NY	10016	NEW YORK	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	002	2	4/29/2022	NON-COMPETING CONTINUATION	-$425,443
2022	2021	NEW YORK UNIVERSITY	550 1ST AVE	NEW YORK	NY	10016	NEW YORK	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	2	2/24/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $398,251

Issue Date FY: 2021 ( Subtotal = $427,162 )
2021	2021	NEW YORK UNIVERSITY	550 1ST AVE	NEW YORK	NY	10016	NEW YORK	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	2	3/2/2021	NON-COMPETING CONTINUATION	$427,162
														Subtotal = $427,162

Issue Date FY: 2020 ( Subtotal = $424,365 )
2020	2020	NEW YORK UNIVERSITY	550 1ST AVE	NEW YORK	NY	10016	NEW YORK	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	1	3/18/2020	NEW	$424,365
														Subtotal = $424,365

Grand Total All Awards = $2,029,229

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Development and Function of Sleep Circuits - Extramural Research Programs in the Neurosciences and Neurological Disorders

Award Number: R01NS112844

ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 04/01/2020

PERIOD OF PERFORMANCE END DATE: 03/31/2026

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