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Sex differences in the ability to recover from sleep loss: the roles of development and sex chromosome dosage

Award Number: R01NS078410
ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Project Summary/Abstract Sex differences in daily sleep amount, sleep fragmentation, and basal slow wave activity (SWA) are largely driven by gonadal hormones. However, sex differences in the mid-active phase sleep amount and the ability to recover from sleep loss are largely insensitive to gonadal hormones, and are regulated in part by sex chromosomes. Preliminary data in this application show that a key determinant of sex differences in active phase sleep amount is the presence or absence of the Sry gene of the Y chromosome, which encodes the testis-determining factor. This study will use two mouse lines with altered sex chromosomes to elucidate the origin of sex differences in sleep and in order to determine the respective roles of Sry gene and chromosome complement on sleep regulatory mechanisms. The first specific aim will test the hypothesis that Sry gene establishes sex differences in sleep homeostasis during development by observing sleep-wake patterns in the EMG of neonatal, prepubertal mice, and EEG/EMG of adult mice with altered sex chromosomes and hormones. The second specific aim will test the hypothesis that X chromosome dosage drives sex differences in the ability to recover from sleep loss. During each of these studies, active-phase sleep amount in mice will be used as a biomarker for sleep homeostasis. These experiments are important and required to understand the role of the sleep homeostat in regulating sleep and how it is established. They are the first comprehensive analysis of sex differences in a juvenile mammalian species and the first to examine the specific effects of either X or Y chromosome dosage on sleep. The overarching goal of these experiments is to identify the specific mechanisms through which sex chromosomes and sex-linked genes are able to regulate sleep. These studies will uncover the origins of sex differences in the homeostatic ability to recover from sleep loss. These findings will likely lead to improved therapies for sleep disorders that exhibit sex differences in incidence and severity, particularly those more prevalent in women.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $381,240 )
2024	2024	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90024	LOS ANGELES	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	10	4/8/2024	NON-COMPETING CONTINUATION	$381,240
														Subtotal = $381,240

Issue Date FY: 2023 ( Subtotal = $393,030 )
2023	2023	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90024	LOS ANGELES	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	9	4/26/2023	NON-COMPETING CONTINUATION	$393,030
														Subtotal = $393,030

Issue Date FY: 2022 ( Subtotal = $393,030 )
2022	2022	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90024	LOS ANGELES	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	8	4/1/2022	NON-COMPETING CONTINUATION	$393,030
2022	2016	MOREHOUSE SCHOOL OF MEDICINE, INC.	720 WESTVIEW DR SW	ATLANTA	GA	30310	FULTON	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	5	10/1/2021	EXTENSION WITH OR WITHOUT FUNDS	$0
														Subtotal = $393,030

Issue Date FY: 2021 ( Subtotal = $393,030 )
2021	2021	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90095	LOS ANGELES	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	7	5/15/2021	COMPETING CONTINUATION	$393,030
														Subtotal = $393,030

Issue Date FY: 2020 ( Subtotal = $0 )
2020	2016	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90095	LOS ANGELES	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	6	9/8/2020	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$0
														Subtotal = $0

Issue Date FY: 2019 ( Subtotal = $0 )
2019	2016	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90095	LOS ANGELES	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	6	6/5/2019	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$0
														Subtotal = $0

Issue Date FY: 2017 ( Subtotal = $1 )
2017	2016	MOREHOUSE SCHOOL OF MEDICINE, INC., THE	720 WESTVIEW DR SW	ATLANTA	GA	30310	FULTON	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	002	5	6/6/2017	EXTENSION WITH OR WITHOUT FUNDS	-$75,967
2017	2016	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90095	LOS ANGELES	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	003	6	6/6/2017	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$75,967
2017	2016	MOREHOUSE SCHOOL OF MEDICINE, INC., THE	720 WESTVIEW DR SW	ATLANTA	GA	30310	FULTON	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	5	5/4/2017	EXTENSION WITH OR WITHOUT FUNDS	-$242,318
2017	2016	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90095	LOS ANGELES	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	6	5/5/2017	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$242,319
														Subtotal = $1

Issue Date FY: 2016 ( Subtotal = $341,987 )
2016	2016	MOREHOUSE SCHOOL OF MEDICINE	720 WESTVIEW DRIVE, S.W.	ATLANTA	GA	30310	FULTON	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	5	2/25/2016	EXTENSION WITH OR WITHOUT FUNDS	$341,987
														Subtotal = $341,987

Issue Date FY: 2015 ( Subtotal = $439,357 )
2015	2015	MOREHOUSE SCHOOL OF MEDICINE	720 WESTVIEW DRIVE, S.W.	ATLANTA	GA	30310	FULTON	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	4	2/27/2015	NON-COMPETING CONTINUATION	$439,357
2015	2014	MOREHOUSE SCHOOL OF MEDICINE	720 WESTVIEW DRIVE, S.W.	ATLANTA	GA	30310	FULTON	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	3	2/25/2015	SUPPLEMENT FOR EXPANSION	$0
														Subtotal = $439,357

Issue Date FY: 2014 ( Subtotal = $401,200 )
2014	2014	MOREHOUSE SCHOOL OF MEDICINE	720 WESTVIEW DRIVE, S.W.	ATLANTA	GA	30310	FULTON	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	3	3/10/2014	NON-COMPETING CONTINUATION	$27,622
2014	2014	MOREHOUSE SCHOOL OF MEDICINE	720 WESTVIEW DRIVE, S.W.	ATLANTA	GA	30310	FULTON	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	3	2/26/2014	NON-COMPETING CONTINUATION	$276,208
2014	2014	MOREHOUSE SCHOOL OF MEDICINE	720 WESTVIEW DRIVE, S.W.	ATLANTA	GA	30310	FULTON	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	002	3	7/8/2014	SUPPLEMENT FOR EXPANSION	$97,370
														Subtotal = $401,200

Issue Date FY: 2013 ( Subtotal = $298,698 )
2013	2013	MOREHOUSE SCHOOL OF MEDICINE	720 WESTVIEW DRIVE, S.W.	ATLANTA	GA	30310	FULTON	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	2	3/22/2013	NON-COMPETING CONTINUATION	$278,578
2013	2013	MOREHOUSE SCHOOL OF MEDICINE	720 WESTVIEW DRIVE, S.W.	ATLANTA	GA	30310	FULTON	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	2	5/23/2013	NON-COMPETING CONTINUATION	$20,120
														Subtotal = $298,698

Issue Date FY: 2012 ( Subtotal = $287,599 )
2012	2012	MOREHOUSE SCHOOL OF MEDICINE	720 WESTVIEW DRIVE, S.W.	ATLANTA	GA	30310	FULTON	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	1	3/8/2012	NEW	$287,599
														Subtotal = $287,599

Grand Total All Awards = $3,329,172

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Sex differences in the ability to recover from sleep loss: the roles of development and sex chromosome dosage

Award Number: R01NS078410

ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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