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Instructive Signals for Motor Learning

Award Number: R01NS072406
ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/01/2010
PERIOD OF PERFORMANCE END DATE: 03/31/2027

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Instructive Signals for Motor Learning - PROJECT SUMMARY Meta-learning refers to the ability to learn to learn. Whereas much progress has been made in understanding the neural mechanisms of learning, the neural mechanisms of meta-learning are a mystery. This project will investigate a candidate synaptic mechanism of meta-learning. Using integrated molecular, cellular, systems, and behavioral neuroscience approaches, the proposed research will test the hypothesis that the timing rules governing synaptic plasticity are themselves learned. Preliminary results suggest that the timing rules for associative synaptic plasticity in the cerebellum can be adaptively tuned though experience to solve what theorists have called the temporal credit assignment problem, precisely compensating for delays in the feedback about behavioral errors, so that only synapses that were active around the time that an error was generated undergo weakening during learning. If confirmed, this would represent a new dimension of the algorithms that neural circuits use to tune their own performance through experience, with broad scientific and clinical implications.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $597,407 )
2025	2025	THE LELAND STANFORD JUNIOR UNIVERSITY	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	14	4/24/2025	NON-COMPETING CONTINUATION	$597,407
														Subtotal = $597,407

Issue Date FY: 2024 ( Subtotal = $581,241 )
2024	2024	THE LELAND STANFORD JUNIOR UNIVERSITY	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	13	4/10/2024	NON-COMPETING CONTINUATION	$41,944
2024	2024	THE LELAND STANFORD JUNIOR UNIVERSITY	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	13	2/22/2024	NON-COMPETING CONTINUATION	$539,297
														Subtotal = $581,241

Issue Date FY: 2023 ( Subtotal = $600,140 )
2023	2023	THE LELAND STANFORD JUNIOR UNIVERSITY	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	12	3/8/2023	NON-COMPETING CONTINUATION	$600,140
														Subtotal = $600,140

Issue Date FY: 2022 ( Subtotal = $621,539 )
2022	2022	LELAND STANFORD JUNIOR UNIVERSITY, THE	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	11	3/25/2022	COMPETING CONTINUATION	$621,539
2022	2019	LELAND STANFORD JUNIOR UNIVERSITY, THE	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	10	11/27/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $621,539

Issue Date FY: 2019 ( Subtotal = $556,524 )
2019	2019	LELAND STANFORD JUNIOR UNIVERSITY, THE	450 SERRA MALL	STANFORD	CA	94305	SANTA CLARA	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	10	7/24/2019	NON-COMPETING CONTINUATION	$480,336
2019	2019	LELAND STANFORD JUNIOR UNIVERSITY, THE	450 SERRA MALL	STANFORD	CA	94305	SANTA CLARA	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	9	1/15/2019	SUPPLEMENT FOR EXPANSION	$76,188
														Subtotal = $556,524

Issue Date FY: 2018 ( Subtotal = $477,795 )
2018	2018	LELAND STANFORD JUNIOR UNIVERSITY, THE	450 SERRA MALL	STANFORD	CA	94305	SANTA CLARA	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	9	7/20/2018	NON-COMPETING CONTINUATION	$477,795
														Subtotal = $477,795

Issue Date FY: 2017 ( Subtotal = $479,269 )
2017	2017	LELAND STANFORD JUNIOR UNIVERSITY, THE	450 SERRA MALL	STANFORD	CA	94305	SANTA CLARA	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	8	8/2/2017	NON-COMPETING CONTINUATION	$479,269
														Subtotal = $479,269

Issue Date FY: 2016 ( Subtotal = $476,856 )
2016	2016	STANFORD UNIVERSITY	651 SERRA STREET, ROOM 110	STANFORD	CA	94305	SANTA CLARA	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	7	8/1/2016	NON-COMPETING CONTINUATION	$476,856
														Subtotal = $476,856

Issue Date FY: 2015 ( Subtotal = $473,336 )
2015	2015	STANFORD UNIVERSITY	651 SERRA STREET, ROOM 110	STANFORD	CA	94305	SANTA CLARA	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	6	7/20/2015	COMPETING CONTINUATION	$473,336
														Subtotal = $473,336

Issue Date FY: 2014 ( Subtotal = $434,680 )
2014	2014	STANFORD UNIVERSITY	651 SERRA STREET, ROOM 110	STANFORD	CA	94305	SANTA CLARA	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	5	7/30/2014	NON-COMPETING CONTINUATION	$434,680
														Subtotal = $434,680

Issue Date FY: 2013 ( Subtotal = $423,744 )
2013	2013	STANFORD UNIVERSITY	651 SERRA STREET, ROOM 110	STANFORD	CA	94305	SANTA CLARA	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	4	7/19/2013	NON-COMPETING CONTINUATION	$423,744
														Subtotal = $423,744

Issue Date FY: 2012 ( Subtotal = $451,187 )
2012	2012	STANFORD UNIVERSITY	651 SERRA STREET, ROOM 110	STANFORD	CA	94305	SANTA CLARA	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	3	7/17/2012	NON-COMPETING CONTINUATION	$439,206
2012	2012	STANFORD UNIVERSITY	651 SERRA STREET, ROOM 110	STANFORD	CA	94305	SANTA CLARA	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	2	12/30/2011	SUPPLEMENT FOR EXPANSION	$11,981
														Subtotal = $451,187

Issue Date FY: 2011 ( Subtotal = $439,344 )
2011	2011	STANFORD UNIVERSITY	651 SERRA STREET, ROOM 110	STANFORD	CA	94305	SANTA CLARA	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	2	7/14/2011	NON-COMPETING CONTINUATION	$439,344
														Subtotal = $439,344

Issue Date FY: 2010 ( Subtotal = $443,971 )
2010	2010	STANFORD UNIVERSITY	651 SERRA STREET, ROOM 110	STANFORD	CA	94305	SANTA CLARA	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	1	9/3/2010	NEW	-$5,885
2010	2010	STANFORD UNIVERSITY	651 SERRA STREET, ROOM 110	STANFORD	CA	94305	SANTA CLARA	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	1	8/26/2010	NEW	$449,856
														Subtotal = $443,971

Grand Total All Awards = $7,057,033

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Instructive Signals for Motor Learning

Award Number: R01NS072406

ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/01/2010

PERIOD OF PERFORMANCE END DATE: 03/31/2027

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