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Pathways to successful aging among perinatally HIV-infected and exposed young adults: Risk, resilience, and the role of perinatal HIV infection

Award Number: R01MH069133
ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 12/11/2003
PERIOD OF PERFORMANCE END DATE: 12/31/2025

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Pathways to successful aging among perinatally HIV-infected and exposed young adults: Risk, resilience, and the role of perinatal HIV infection - Advances in HIV treatment and prevention have led to millions of perinatally HIV-infected (PHIV) and perinatally HIV-exposed, but uninfected (PHEU) children surviving into adolescence and young adulthood. Young adulthood can be a precarious developmental period, and PHIV young adults (YA) are at particularly high risk for mental health problems, risk behaviors, and difficulties achieving adult milestones due to a “perfect storm” of compromised health, life stressors, and neurocognitive deficits. These risks are exacerbated by inadequately controlled HIV, and psychosocial stressors encountered by both PHIV and PHEU YA, leading to chronic inflammatory responses that compromise psychiatric function, neurocognition, and overall health outcomes. For the past 15 years, CASAH has followed 340 PHIV and PHEU youth (enrolled at ages 9-16 years) living in vulnerable communities in New York City, documenting risk and resilience across childhood, adolescence, and emerging adulthood. This competing continuation of CASAH (R01-MH69133-15), CASAH4, will follow this cohort through young adulthood (20s-early 30s), leading to one of the most comprehensive longitudinal data sets on mental health, health risk behavior, and achievement of adult milestones among PHIV and PHEU YA. Guided by Social Action Theory (SAT), CASAH4 offers a unique opportunity leverage our unique longitudinal data set to understand the impact of both lifelong HIV infection and also contextual, social-regulation, and self-regulation determinants of mental health, health risk behaviors, and adult milestone achievement. In CASAH4 we aim to 1) examine the impact of HIV infection on behavioral health outcomes (e.g., mental health, sexual risk, substance use, adherence) and achievement of adult milestones (e.g., education, vocation, independence); 2) examine how SAT-informed risk and protective factors affect YA behavioral health and achievement of adult milestones; 3) explore trajectories of behavioral health across adolescence and young adulthood and SAT-informed predictors of these trajectories; and 4) compare behavioral health outcomes and their SAT-informed predictors among youth across three global cohorts by PHIV-status at early (9-12 years), middle (13-15 years), and late (16-19 years) adolescence. Building on our previous work, we will enhance our assessment of adult milestones, psychiatric function, and neurocognitive function, and will add biomedical health indicators (inflammation and immune activation biomarkers associated with psychiatric disorders and neurocognitive function) to the HIV RNA viral load and CD4+ cell count already collected. CASAH has made significant contributions to research on risk and resilience in PHIV and PHEU youth with 117 publications and 65 scientific presentations, and has directly informed mental- health and HIV-prevention interventions and service systems in the US and abroad. With a multidisciplinary and cross-cultural team, we have a unique opportunity to extended our work into young adulthood, to identify modifiable predictors of behavioral risk trajectories and young adult function, and to inform the development of timely, targeted, and evidence-based interventions for vulnerable PHIV and PHEU across global contexts.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2023	RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC.	1051 RIVERSIDE DR	NEW YORK	NY	10032	NEW YORK	USA	Mental Health Research Grants	000	20	5/21/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2023 ( Subtotal = $604,514 )
2023	2023	RESEARCH FOUNDATION FOR MENTAL HYGIENE INC	1051 RIVERSIDE DR	NEW YORK	NY	10032	NEW YORK	USA	Mental Health Research Grants	002	20	8/7/2023	NON-COMPETING CONTINUATION	$0
2023	2023	RESEARCH FOUNDATION FOR MENTAL HYGIENE INC	1051 RIVERSIDE DR	NEW YORK	NY	10032	NEW YORK	USA	Mental Health Research Grants	000	20	1/30/2023	NON-COMPETING CONTINUATION	$604,514
2023	2022	RESEARCH FOUNDATION FOR MENTAL HYGIENE INC	1051 RIVERSIDE DR	NEW YORK	NY	10032	NEW YORK	USA	Mental Health Research Grants	001	19	1/30/2023	SUPPLEMENT FOR EXPANSION	$0
														Subtotal = $604,514

Issue Date FY: 2022 ( Subtotal = $974,008 )
2022	2022	RESEARCH FOUNDATION FOR MENTAL HYGIENE INC	1051 RIVERSIDE DR	NEW YORK	NY	10032	NEW YORK	USA	Mental Health Research Grants	001	19	5/10/2022	NON-COMPETING CONTINUATION	$66,494
2022	2022	RESEARCH FOUNDATION FOR MENTAL HYGIENE INC	1051 RIVERSIDE DR	NEW YORK	NY	10032	NEW YORK	USA	Mental Health Research Grants	002	19	8/31/2022	SUPPLEMENT FOR EXPANSION	$309,076
2022	2022	RESEARCH FOUNDATION FOR MENTAL HYGIENE INC	1051 RIVERSIDE DR	NEW YORK	NY	10032	NEW YORK	USA	Mental Health Research Grants	000	19	12/16/2021	NON-COMPETING CONTINUATION	$598,438
														Subtotal = $974,008

Issue Date FY: 2021 ( Subtotal = $682,951 )
2021	2021	RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC.	1051 RIVERSIDE DR	NEW YORK	NY	10032	NEW YORK	USA	Mental Health Research Grants	000	18	1/25/2021	NON-COMPETING CONTINUATION	$682,951
														Subtotal = $682,951

Issue Date FY: 2020 ( Subtotal = $682,070 )
2020	2020	RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC.	1051 RIVERSIDE DR	NEW YORK	NY	10032	NEW YORK	USA	Mental Health Research Grants	000	17	12/13/2019	NON-COMPETING CONTINUATION	$613,863
2020	2020	RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC.	1051 RIVERSIDE DR	NEW YORK	NY	10032	NEW YORK	USA	Mental Health Research Grants	001	17	3/11/2020	NON-COMPETING CONTINUATION	$68,207
														Subtotal = $682,070

Issue Date FY: 2019 ( Subtotal = $746,340 )
2019	2019	RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC.	1051 RIVERSIDE DR	NEW YORK	NY	10032	NEW YORK	USA	Mental Health Research Grants	003	16	7/19/2019	COMPETING CONTINUATION	$39,978
2019	2019	RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC.	1051 RIVERSIDE DR	NEW YORK	NY	10032	NEW YORK	USA	Mental Health Research Grants	001	16	3/22/2019	COMPETING CONTINUATION	$696,340
2019	2019	RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC.	1051 RIVERSIDE DR	NEW YORK	NY	10032	NEW YORK	USA	Mental Health Research Grants	004	16	9/25/2019	COMPETING CONTINUATION	$50,000
2019	2018	RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC.	1051 RIVERSIDE DR	NEW YORK	NY	10032	NEW YORK	USA	Mental Health Research Grants	002	15	7/19/2019	NON-COMPETING CONTINUATION	-$39,978
2019	2018	RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC.	1051 RIVERSIDE DR	NEW YORK	NY	10032	NEW YORK	USA	Mental Health Research Grants	000	15	3/19/2019	NON-COMPETING CONTINUATION	$0
														Subtotal = $746,340

Issue Date FY: 2018 ( Subtotal = $635,757 )
2018	2018	RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC.	1051 RIVERSIDE DR	NEW YORK	NY	10032	NEW YORK	USA	Mental Health Research Grants	000	15	11/6/2017	NON-COMPETING CONTINUATION	$572,181
2018	2018	RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC.	1051 RIVERSIDE DR	NEW YORK	NY	10032	NEW YORK	USA	Mental Health Research Grants	001	15	6/14/2018	NON-COMPETING CONTINUATION	$63,576
														Subtotal = $635,757

Issue Date FY: 2017 ( Subtotal = $670,517 )
2017	2017	RESEARCH FOUNDATION FOR MENTAL HYGIENE INC	1051 RIVERSIDE DR	NEW YORK	NY	10032	NEW YORK	USA	Mental Health Research Grants	000	14	11/4/2016	NON-COMPETING CONTINUATION	$603,465
2017	2017	RESEARCH FOUNDATION FOR MENTAL HYGIENE INC	1051 RIVERSIDE DR	NEW YORK	NY	10032	NEW YORK	USA	Mental Health Research Grants	001	14	5/9/2017	NON-COMPETING CONTINUATION	$67,052
														Subtotal = $670,517

Issue Date FY: 2016 ( Subtotal = $864,076 )
2016	2016	RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC	150 BROADWAY SUITE 301	MENANDS	NY	12204	ALBANY	USA	Mental Health Research Grants	001	13	3/12/2016	NON-COMPETING CONTINUATION	$68,562
2016	2016	RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC	150 BROADWAY SUITE 301	MENANDS	NY	12204	ALBANY	USA	Mental Health Research Grants	000	13	11/23/2015	NON-COMPETING CONTINUATION	$617,056
2016	2016	RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC	150 BROADWAY SUITE 301	MENANDS	NY	12204	ALBANY	USA	Mental Health Research Grants	002	13	6/28/2016	SUPPLEMENT FOR EXPANSION	$178,458
														Subtotal = $864,076

Issue Date FY: 2015 ( Subtotal = $690,084 )
2015	2015	RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC	150 BROADWAY SUITE 301	MENANDS	NY	12204	ALBANY	USA	Mental Health Research Grants	000	12	11/21/2014	NON-COMPETING CONTINUATION	$621,075
2015	2015	RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC	150 BROADWAY SUITE 301	MENANDS	NY	12204	ALBANY	USA	Mental Health Research Grants	001	12	1/7/2015	NON-COMPETING CONTINUATION	$69,009
														Subtotal = $690,084

Issue Date FY: 2014 ( Subtotal = $822,320 )
2014	2014	RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC	150 BROADWAY SUITE 301	MENANDS	NY	12204	ALBANY	USA	Mental Health Research Grants	001	11	9/22/2014	COMPETING CONTINUATION	$80,508
2014	2014	RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC	150 BROADWAY SUITE 301	MENANDS	NY	12204	ALBANY	USA	Mental Health Research Grants	000	11	11/26/2013	COMPETING CONTINUATION	$741,812
														Subtotal = $822,320

Issue Date FY: 2013 ( Subtotal = $550,265 )
2013	2013	RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC	150 BROADWAY SUITE 301	MENANDS	NY	12204	ALBANY	USA	Mental Health Research Grants	000	10	11/15/2012	NON-COMPETING CONTINUATION	$515,874
2013	2013	RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC	150 BROADWAY SUITE 301	MENANDS	NY	12204	ALBANY	USA	Mental Health Research Grants	001	10	6/10/2013	NON-COMPETING CONTINUATION	$34,391
														Subtotal = $550,265

Issue Date FY: 2012 ( Subtotal = $666,783 )
2012	2012	RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC	150 BROADWAY SUITE 301	MENANDS	NY	12204	ALBANY	USA	Mental Health Research Grants	000	9	10/31/2011	NON-COMPETING CONTINUATION	$612,107
2012	2012	RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC	150 BROADWAY SUITE 301	MENANDS	NY	12204	ALBANY	USA	Mental Health Research Grants	001	9	4/5/2012	NON-COMPETING CONTINUATION	$54,676
														Subtotal = $666,783

Issue Date FY: 2011 ( Subtotal = $655,981 )
2011	2011	RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC	150 BROADWAY SUITE 301	MENANDS	NY	12204	ALBANY	USA	Mental Health Research Grants	001	8	6/22/2011	NON-COMPETING CONTINUATION	$41,745
2011	2011	RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC	150 BROADWAY SUITE 301	MENANDS	NY	12204	ALBANY	USA	Mental Health Research Grants	000	8	11/17/2010	NON-COMPETING CONTINUATION	$614,236
														Subtotal = $655,981

Issue Date FY: 2010 ( Subtotal = $662,866 )
2010	2010	RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC	150 BROADWAY SUITE 301	MENANDS	NY	12204	ALBANY	USA	Mental Health Research Grants	000	7	12/7/2009	NON-COMPETING CONTINUATION	$605,665
2010	2010	RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC	150 BROADWAY SUITE 301	MENANDS	NY	12204	ALBANY	USA	Mental Health Research Grants	001	7	2/17/2010	NON-COMPETING CONTINUATION	$57,201
														Subtotal = $662,866

Issue Date FY: 2009 ( Subtotal = $1,057,533 ) (Continued on the next page)
Grand Total All Awards = $14,285,186

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Pathways to successful aging among perinatally HIV-infected and exposed young adults: Risk, resilience, and the role of perinatal HIV infection

Award Number: R01MH069133

ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 12/11/2003

PERIOD OF PERFORMANCE END DATE: 12/31/2025

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