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Mechanisms of Juxta-Cardiac Field Progenitors

Award Number: R01HL174023
ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 07/01/2024
PERIOD OF PERFORMANCE END DATE: 06/30/2028

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Mechanisms of Juxta-Cardiac Field Progenitors - Project Summary The heart is composed of a broad range of diverse cardiac cell types, which organize into distinct cardiac structures that coordinately regulate cardiac function and circulation throughout the body. Despite efforts devoted toward understanding how these cardiac cell types are created in order to develop potential human cardiac therapies and/or illuminate underlying mechanisms/etiologies of congenital heart disease (CHD), our understanding of how diverse cardiac cell types emerge from developmental heart field progenitors, and how they organize into heart structures remains to be fully defined. Thus, we propose to identify and investigate the cardiovascular developmental regulators and gene regulatory networks that direct the development of Juxta- Cardiac Field (JCF)-derived cardiovascular cell types creating the mammalian heart. Toward this end, a multi- disciplinary experimental and computational systems biology approach will be employed to: (1) examine the contribution of JCF progenitors to the developing heart, (2) investigate how JCF progenitors differentiate into specific cell types contributing to heart development and (3) investigate whether mechanisms in JCF development are conserved in human heart development.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $763,930 )
2025	2025	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR	LA JOLLA	CA	92093	SAN DIEGO	USA	Cardiovascular Diseases Research	000	2	7/8/2025	NON-COMPETING CONTINUATION	$763,930
														Subtotal = $763,930

Issue Date FY: 2024 ( Subtotal = $763,930 )
2024	2024	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR	LA JOLLA	CA	92093	SAN DIEGO	USA	Cardiovascular Diseases Research	000	1	3/6/2024	NEW	$687,537
2024	2024	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR	LA JOLLA	CA	92093	SAN DIEGO	USA	Cardiovascular Diseases Research	001	1	6/6/2024	NEW	$76,393
														Subtotal = $763,930

Grand Total All Awards = $1,527,860

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Mechanisms of Juxta-Cardiac Field Progenitors

Award Number: R01HL174023

ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 07/01/2024

PERIOD OF PERFORMANCE END DATE: 06/30/2028

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