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Basic and Clinical Studies in Reinforcing Positive Behaviors in Intellectual and Developmental Disabilities

Award Number: R01HD093734
ORGANIZATION: NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Project Summary Understanding complex, comorbid conditions of intellectual developmental disorder (IDD) is an NICHD priority. Severe problem behavior (e.g., self-injurious behavior, aggression) of children with IDD is prevalent, potentially dangerous, and negatively impacts social integration and quality of life. Function-based differential- reinforcement-of-alternative-behavior interventions reduce such behavior effectively, but treatment relapse is common when a caregiver cannot deliver reinforcement for the alternative behavior. Such relapse is known as resurgence. Previously, we developed a quantitative theory of resurgence based on two well-established principles: (1) individuals allocate proportionally more responding to options that produce proportionally more reinforcement, and (2) the value of past reinforcement decays hyperbolically as time passes. The theory provides a quantitative account of behavior in dynamically changing reinforcement conditions, including when all reinforcement ceases (i.e., extinction)—the conditions giving rise to resurgence. In Period 1 of this project, we showed the quantitative accuracy of many of the theory’s predictions with laboratory animals and we have shown similar relations in resurgence of severe problem behavior of children with IDD in the clinic. However, the most important and promising finding from Period 1 was one the theory failed to predict. We found that exposure to a treatment (i.e., contingency discrimination training, CDT) involving alternating sessions in which alternative reinforcement was and then was not available during continued extinction of a target response substantially mitigated resurgence. To account for these effects, we have developed a refined version of the quantitative theory suggesting that individuals exposed to CDT rapidly learn to discriminate the continued unavailability of reinforcement for the target behavior, even when reinforcement is not available for the alternative response, thus serving to inoculating them against later resurgence. These findings and the refined quantitative theory from Period 1 suggest promising, innovative, and unexplored procedures for treating severe problem behavior that are likely to produce better resurgence mitigation than existing approaches, while also avoiding some downsides of the current methods to mitigate resurgence of problem behavior (i.e., arbitrary stimuli that caregivers may lose or use incorrectly). Period 2 of this project will focus on this highly innovative approach identified in Period 1 in two aims by conducting: (1) the first randomized controlled trial evaluating the resurgence-mitigating effects of CDT on severe problem behavior of children with IDD and (2) a series of experiments with laboratory animals testing the refined theory under a range of conditions predicted to improve the efficacy, efficiency, and practicality of CDT in future clinical applications. This project represents a close collaboration between basic and clinical scientists with a demonstrated ability to use basic quantitative theoretical and empirical research to improve clinical practice to prevent relapse of severe problem behavior, and thus, to reduce its devastating impact on children and their families.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $546,103 )
2024	2024	UTAH STATE UNIVERSITY	1000 OLD MAIN HL	LOGAN	UT	84322	CACHE	USA	Child Health and Human Development Extramural Research	000	7	1/24/2024	NON-COMPETING CONTINUATION	$546,103
														Subtotal = $546,103

Issue Date FY: 2023 ( Subtotal = $632,093 )
2023	2023	UTAH STATE UNIVERSITY	1000 OLD MAIN HILL	LOGAN	UT	84322	CACHE	USA	Child Health and Human Development Extramural Research	000	6	1/31/2023	COMPETING CONTINUATION	$632,093
														Subtotal = $632,093

Issue Date FY: 2022 ( Subtotal = $535,676 )
2022	2022	UTAH STATE UNIVERSITY	1000 OLD MAIN HILL	LOGAN	UT	84322	CACHE	USA	Child Health and Human Development Extramural Research	000	5	1/24/2022	NON-COMPETING CONTINUATION	$482,109
2022	2022	UTAH STATE UNIVERSITY	1000 OLD MAIN HILL	LOGAN	UT	84322	CACHE	USA	Child Health and Human Development Extramural Research	002	5	5/13/2022	NON-COMPETING CONTINUATION	$0
2022	2022	UTAH STATE UNIVERSITY	1000 OLD MAIN HILL	LOGAN	UT	84322	CACHE	USA	Child Health and Human Development Extramural Research	001	5	4/27/2022	NON-COMPETING CONTINUATION	$53,567
														Subtotal = $535,676

Issue Date FY: 2021 ( Subtotal = $535,676 )
2021	2021	UTAH STATE UNIVERSITY	1000 OLD MAIN HILL	LOGAN	UT	84322	CACHE	USA	Child Health and Human Development Extramural Research	001	4	4/2/2021	NON-COMPETING CONTINUATION	$0
2021	2021	UTAH STATE UNIVERSITY	1000 OLD MAIN HILL	LOGAN	UT	84322	CACHE	USA	Child Health and Human Development Extramural Research	000	4	2/10/2021	NON-COMPETING CONTINUATION	$535,676
														Subtotal = $535,676

Issue Date FY: 2020 ( Subtotal = $546,609 )
2020	2020	UTAH STATE UNIVERSITY	1000 OLD MAIN HILL	LOGAN	UT	84322	CACHE	USA	Child Health and Human Development Extramural Research	000	3	2/6/2020	NON-COMPETING CONTINUATION	$546,609
														Subtotal = $546,609

Issue Date FY: 2019 ( Subtotal = $546,609 )
2019	2019	UTAH STATE UNIVERSITY	1000 OLD MAIN HILL	LOGAN	UT	84322	CACHE	USA	Child Health and Human Development Extramural Research	000	2	1/29/2019	NON-COMPETING CONTINUATION	$546,609
														Subtotal = $546,609

Issue Date FY: 2018 ( Subtotal = $573,119 )
2018	2018	UTAH STATE UNIVERSITY	1000 OLD MAIN HILL	LOGAN	UT	84322	CACHE	USA	Child Health and Human Development Extramural Research	000	1	2/8/2018	NEW	$573,119
														Subtotal = $573,119

Grand Total All Awards = $3,915,885

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Basic and Clinical Studies in Reinforcing Positive Behaviors in Intellectual and Developmental Disabilities

Award Number: R01HD093734

ORGANIZATION: NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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