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Assembly and Function of the Yeast Spore Wall

Award Number: R01GM072540
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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7. PROJECT SUMMARY/ABSTRACT Fungal infections are a significant public health problem and one difficulty in treatment of these infections is the small number of available antifungal drugs. Moreover, existing treatments suffer both from significant side effects and the frequent appearance of resistant strains. The cell wall is an essential organelle of the fungal cell. Because the cell wall is essential for viability, drugs that inhibit fungal cell wall assembly are potential antifungal agents. Indeed, one major class of current antifungals targets ß-glucan synthase, a key enzyme in cell wall synthesis. In budding yeast, the haploid genomes produced by meiosis are encapsulated by a multi-layered spore wall, which allows spores to resist a variety of environmental stresses. The inner layers of the spore wall are composed of mannan and ß-glucan, similar to the vegetative cell wall. The outer layers of the spore wall are comprised of the polysaccharide chitosan, the polyphenol dityrosine and a third, poorly characterized component termed Chi. These outer spore wall components are absent from vegetative cell walls and primarily responsible for the stress resistance of spores. Importantly, although chitosan and dityrosine are absent from vegetative cell walls in budding yeast, they are present in the walls of pathogenic fungi. The budding yeast spore wall therefore provides an excellent model system to study fungal wall morphogenesis. This grant is focused on understanding the activity and regulation of conserved enzymes involved in synthesis and assembly of different spore wall components with the long-term goal of identifying new targets for antifungal drug development


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2023 ( Subtotal = $369,641 )
2023	2023	THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK	W5510 FRANKS MELVILLE MEMORIAL LIBRARY	STONY BROOK	NY	11794	SUFFOLK	USA	Biomedical Research and Research Training	002	18	8/23/2023	NON-COMPETING CONTINUATION	$369,641
2023	2022	THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK	W5510 FRANKS MELVILLE MEMORIAL LIBRARY	STONY BROOK	NY	11794	SUFFOLK	USA	Biomedical Research and Research Training	001	17	3/20/2023	COMPETING CONTINUATION	$58,583
2023	2021	THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK	W5510 FRANKS MELVILLE MEMORIAL LIBRARY	STONY BROOK	NY	11794	SUFFOLK	USA	Biomedical Research and Research Training	000	16	3/20/2023	NON-COMPETING CONTINUATION	-$58,583
														Subtotal = $369,641

Issue Date FY: 2022 ( Subtotal = $369,641 )
2022	2022	RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE	WEST 5510 FRANKS MELVILLE MEMORIAL LIBRARY	STONY BROOK	NY	11794	SUFFOLK	USA	Biomedical Research and Research Training	000	17	8/2/2022	COMPETING CONTINUATION	$369,641
														Subtotal = $369,641

Issue Date FY: 2021 ( Subtotal = $358,875 )
2021	2021	RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE	WEST 5510 FRANKS MELVILLE MEMORIAL LIBRARY	STONY BROOK	NY	11794	SUFFOLK	USA	Biomedical Research and Research Training	000	16	8/31/2021	NON-COMPETING CONTINUATION	$358,875
														Subtotal = $358,875

Issue Date FY: 2020 ( Subtotal = $405,447 )
2020	2020	RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE	WEST 5510 FRANKS MELVILLE MEMORIAL LIBRARY	STONY BROOK	NY	11794	SUFFOLK	USA	Biomedical Research and Research Training	002	15	9/10/2020	NON-COMPETING CONTINUATION	$405,447
2020	2018	RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE	WEST 5510 FRANKS MELVILLE MEMORIAL LIBRARY	STONY BROOK	NY	11794	SUFFOLK	USA	Biomedical Research and Research Training	001	13	11/15/2019	COMPETING CONTINUATION	$43,949
2020	2017	RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE	WEST 5510 FRANKS MELVILLE MEMORIAL LIBRARY	STONY BROOK	NY	11794	SUFFOLK	USA	Biomedical Research and Research Training	000	12	11/15/2019	NON-COMPETING CONTINUATION	-$43,949
														Subtotal = $405,447

Issue Date FY: 2019 ( Subtotal = $516,825 )
2019	2019	RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE	WEST 5510 FRANKS MELVILLE MEMORIAL LIBRARY	STONY BROOK	NY	11794	SUFFOLK	USA	Biomedical Research and Research Training	000	13	6/5/2019	SUPPLEMENT FOR EXPANSION	$16,003
2019	2019	RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE	WEST 5510 FRANKS MELVILLE MEMORIAL LIBRARY	STONY BROOK	NY	11794	SUFFOLK	USA	Biomedical Research and Research Training	002	14	8/23/2019	SUPPLEMENT FOR EXPANSION	$78,415
2019	2019	RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE	WEST 5510 FRANKS MELVILLE MEMORIAL LIBRARY	STONY BROOK	NY	11794	SUFFOLK	USA	Biomedical Research and Research Training	001	14	8/21/2019	NON-COMPETING CONTINUATION	$422,407
														Subtotal = $516,825

Issue Date FY: 2018 ( Subtotal = $358,875 )
2018	2018	RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE	WEST 5510 FRANKS MELVILLE MEMORIAL LIBRARY	STONY BROOK	NY	11794	SUFFOLK	USA	Biomedical Research and Research Training	000	13	8/22/2018	COMPETING CONTINUATION	$358,875
														Subtotal = $358,875

Issue Date FY: 2017 ( Subtotal = $330,243 )
2017	2017	RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE	WEST 5510 FRANKS MELVILLE MEMORIAL LIBRARY	STONY BROOK	NY	11794	SUFFOLK	USA	Biomedical Research and Research Training	000	12	8/21/2017	NON-COMPETING CONTINUATION	$330,243
														Subtotal = $330,243

Issue Date FY: 2016 ( Subtotal = $330,243 )
2016	2016	SUNY, STONY BROOK	OFFICE OF RESEARCH SERVICES	STONY BROOK	NY	11794	SUFFOLK	USA	Biomedical Research and Research Training	000	11	8/19/2016	NON-COMPETING CONTINUATION	$330,243
														Subtotal = $330,243

Issue Date FY: 2015 ( Subtotal = $330,243 )
2015	2015	SUNY, STONY BROOK	OFFICE OF RESEARCH SERVICES	STONY BROOK	NY	11794	SUFFOLK	USA	Biomedical Research and Research Training	000	10	7/10/2015	NON-COMPETING CONTINUATION	$330,243
														Subtotal = $330,243

Issue Date FY: 2014 ( Subtotal = $330,243 )
2014	2014	SUNY, STONY BROOK	OFFICE OF RESEARCH SERVICES	STONY BROOK	NY	11794	SUFFOLK	USA	Biomedical Research and Research Training	000	9	9/5/2014	COMPETING CONTINUATION	$330,243
														Subtotal = $330,243

Issue Date FY: 2013 ( Subtotal = $309,304 )
2013	2013	SUNY, STONY BROOK	OFFICE OF RESEARCH SERVICES	STONY BROOK	NY	11794	SUFFOLK	USA	Biomedical Research and Research Training	000	8	8/20/2013	NON-COMPETING CONTINUATION	$309,304
														Subtotal = $309,304

Issue Date FY: 2012 ( Subtotal = $320,523 )
2012	2012	SUNY, STONY BROOK	OFFICE OF RESEARCH SERVICES	STONY BROOK	NY	11794	SUFFOLK	USA	Biomedical Research and Research Training	000	7	8/31/2012	NON-COMPETING CONTINUATION	$320,523
														Subtotal = $320,523

Issue Date FY: 2011 ( Subtotal = $320,523 )
2011	2011	SUNY, STONY BROOK	OFFICE OF RESEARCH SERVICES	STONY BROOK	NY	11794	SUFFOLK	USA	Biomedical Research and Research Training	000	6	9/5/2011	NON-COMPETING CONTINUATION	$320,523
														Subtotal = $320,523

Issue Date FY: 2010 ( Subtotal = $319,032 )
2010	2010	SUNY, STONY BROOK	OFFICE OF RESEARCH SERVICES	STONY BROOK	NY	11794	SUFFOLK	USA	Biomedical Research and Research Training	000	5	8/30/2010	COMPETING CONTINUATION	$319,032
														Subtotal = $319,032

Issue Date FY: 2009 ( Subtotal = $192,685 )
2009	2009	SUNY, STONY BROOK	OFFICE OF RESEARCH SERVICES	STONY BROOK	NY	11794	SUFFOLK	USA	Trans-NIH Recovery Act Research Support	000	4	9/18/2009	SUPPLEMENT FOR EXPANSION	$192,685
														Subtotal = $192,685

Issue Date FY: 2008 ( Subtotal = $272,754 )
2008	2008	SUNY, STONY BROOK	OFFICE OF RESEARCH SERVICES	STONY BROOK	NY	11794	SUFFOLK	USA	Biomedical Research and Research Training	000	4	7/28/2008	NON-COMPETING CONTINUATION	$272,754
														Subtotal = $272,754

Issue Date FY: 2007 ( Subtotal = $269,936 )
2007	2007	SUNY, STONY BROOK	OFFICE OF RESEARCH SERVICES	STONY BROOK	NY	11794	SUFFOLK	USA	Biomedical Research and Research Training	000	3	9/6/2007	NON-COMPETING CONTINUATION	$269,936
														Subtotal = $269,936

Issue Date FY: 2006 ( Subtotal = $269,948 )
2006	2006	SUNY, STONY BROOK	OFFICE OF RESEARCH SERVICES	STONY BROOK	NY	11794	SUFFOLK	USA	Biomedical Research and Research Training	000	2	9/15/2006	NON-COMPETING CONTINUATION	$269,948
														Subtotal = $269,948

Issue Date FY: 2005 ( Subtotal = $266,318 )
2005	2005	SUNY, STONY BROOK	OFFICE OF RESEARCH SERVICES	STONY BROOK	NY	11794	SUFFOLK	USA	Biomedical Research and Research Training	000	1	9/12/2005	NEW	$266,318
														Subtotal = $266,318

Grand Total All Awards = $6,241,299

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Assembly and Function of the Yeast Spore Wall

Award Number: R01GM072540

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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