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Genetic Regulation of Muscle Fiber Diversity

Award Number: R01GM061738
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 05/01/2001
PERIOD OF PERFORMANCE END DATE: 02/29/2024

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Genetic Regulation of Muscle Fiber Diversity - Project Summary/Abstract: The overall goal of this project is to define the mechanisms that are used to generate diverse muscle fiber types. In animals, different muscle fiber types arise to fine-tune the functions of individuals muscles, to enable those muscles to carry out their distinct roles in the animal. However, there is still much to learn of the cellular and molecular mechanisms that direct groups of myoblasts towards one fiber fate versus others. We have demonstrated that the flight muscles of the adult Drosophila thorax are specified and differentiate using mechanisms that are conserved with vertebrate fast fiber specification. Moreover, we have identified a number of transcriptional regulators that are required for formation of the flight muscles or of the physiologically-distinct jump muscles. In this renewal, we will build upon our studies to define conserved signaling and transcriptional pathways that give rise to different adult muscle fiber types. In the first aim, we will determine how ectodermal signals such as Wingless specify flight muscle specification via Vestigial and the flight muscle identity factor Spalt-major. In the second aim, we will define the roles of orthologs of mammalian Mohawk and Sox6 in regulating muscle fiber identity. In the third aim, we will focus upon how Vestigial and its cofactor Scalloped regulate jump muscle differentiation. Overall, our studies will provide significant new insight into how different muscle fiber types are generated during development in Drosophila. Importantly, our published and preliminary data provide significant evidence that conserved mechanisms regulate muscle fiber fate choices, indicating that our findings can be used as a valuable framework for understanding vertebrate muscle specification. Moreover, since muscle diseases and diabetes often affect the prevalence of one muscle fiber type over another, understanding the normal mechanisms of muscle fiber specification and maintenance can provide insight into the diseased state and how those conditions might be ameliorated.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = -$2,499 )
2024	2022	SAN DIEGO STATE UNIVERSITY FOUNDATION	5250 CAMPANILE DR	SAN DIEGO	CA	92182	SAN DIEGO	USA	Biomedical Research and Research Training	000	21	8/26/2024	NON-COMPETING CONTINUATION	-$2,499
														Subtotal = -$2,499

Issue Date FY: 2022 ( Subtotal = $324,911 )
2022	2022	SAN DIEGO STATE UNIVERSITY FOUNDATION	5250 CAMPANILE DR MC1947	SAN DIEGO	CA	92182	SAN DIEGO	USA	Biomedical Research and Research Training	001	21	7/27/2022	NON-COMPETING CONTINUATION	$32,491
2022	2022	SAN DIEGO STATE UNIVERSITY FOUNDATION	5250 CAMPANILE DR MC1947	SAN DIEGO	CA	92182	SAN DIEGO	USA	Biomedical Research and Research Training	000	21	2/11/2022	NON-COMPETING CONTINUATION	$292,420
														Subtotal = $324,911

Issue Date FY: 2021 ( Subtotal = $392,642 )
2021	2021	SAN DIEGO STATE UNIVERSITY FOUNDATION	5250 CAMPANILE DR MC1947	SAN DIEGO	CA	92182	SAN DIEGO	USA	Biomedical Research and Research Training	000	20	2/16/2021	NON-COMPETING CONTINUATION	$392,642
														Subtotal = $392,642

Issue Date FY: 2020 ( Subtotal = $419,735 )
2020	2020	SAN DIEGO STATE UNIVERSITY FOUNDATION	5250 CAMPANILE DR MC1947	SAN DIEGO	CA	92182	SAN DIEGO	USA	Biomedical Research and Research Training	001	19	2/26/2020	NON-COMPETING CONTINUATION	$406,187
2020	2020	SAN DIEGO STATE UNIVERSITY FOUNDATION	5250 CAMPANILE DR MC1947	SAN DIEGO	CA	92182	SAN DIEGO	USA	Biomedical Research and Research Training	000	18	1/13/2020	SUPPLEMENT FOR EXPANSION	$13,548
														Subtotal = $419,735

Issue Date FY: 2019 ( Subtotal = $324,911 )
2019	2019	SAN DIEGO STATE UNIVERSITY FOUNDATION	5250 CAMPANILE DR MC1947	SAN DIEGO	CA	92182	SAN DIEGO	USA	Biomedical Research and Research Training	001	18	3/15/2019	COMPETING CONTINUATION	$324,911
2019	2019	SAN DIEGO STATE UNIVERSITY FOUNDATION	5250 CAMPANILE DR MC1947	SAN DIEGO	CA	92182	SAN DIEGO	USA	Biomedical Research and Research Training	003	18	7/19/2019	COMPETING CONTINUATION	$602
2019	2018	UNIVERSITY OF NEW MEXICO	1700 LOMAS BLVD NE	ALBUQUERQUE	NM	87106	BERNALILLO	USA	Biomedical Research and Research Training	000	17	3/12/2019	NON-COMPETING CONTINUATION	$0
2019	2018	UNIVERSITY OF NEW MEXICO	1700 LOMAS BLVD NE	ALBUQUERQUE	NM	87106	BERNALILLO	USA	Biomedical Research and Research Training	002	17	7/19/2019	NON-COMPETING CONTINUATION	-$602
														Subtotal = $324,911

Issue Date FY: 2018 ( Subtotal = $315,569 )
2018	2018	UNIVERSITY OF NEW MEXICO	1700 LOMAS BLVD NE	ALBUQUERQUE	NM	87106	BERNALILLO	USA	Biomedical Research and Research Training	000	17	12/19/2017	NON-COMPETING CONTINUATION	$284,012
2018	2018	UNIVERSITY OF NEW MEXICO	1700 LOMAS BLVD NE	ALBUQUERQUE	NM	87106	BERNALILLO	USA	Biomedical Research and Research Training	001	17	6/19/2018	NON-COMPETING CONTINUATION	$31,557
														Subtotal = $315,569

Issue Date FY: 2017 ( Subtotal = $315,681 )
2017	2017	UNIVERSITY OF NEW MEXICO	1700 LOMAS BLVD NE	ALBUQUERQUE	NM	87106	BERNALILLO	USA	Biomedical Research and Research Training	000	16	12/6/2016	NON-COMPETING CONTINUATION	$284,112
2017	2017	UNIVERSITY OF NEW MEXICO	1700 LOMAS BLVD NE	ALBUQUERQUE	NM	87106	BERNALILLO	USA	Biomedical Research and Research Training	001	16	8/3/2017	NON-COMPETING CONTINUATION	$31,569
														Subtotal = $315,681

Issue Date FY: 2016 ( Subtotal = $315,271 )
2016	2016	UNIVERSITY OF NEW MEXICO (THE)	1 UNIVERSITY OF NEW MEXICO	ALBUQUERQUE	NM	87131	BERNALILLO	USA	Biomedical Research and Research Training	000	15	12/14/2015	NON-COMPETING CONTINUATION	$283,743
2016	2016	UNIVERSITY OF NEW MEXICO (THE)	1 UNIVERSITY OF NEW MEXICO	ALBUQUERQUE	NM	87131	BERNALILLO	USA	Biomedical Research and Research Training	001	15	3/1/2016	NON-COMPETING CONTINUATION	$31,528
														Subtotal = $315,271

Issue Date FY: 2015 ( Subtotal = $314,854 )
2015	2015	UNIVERSITY OF NEW MEXICO (THE)	1 UNIVERSITY OF NEW MEXICO	ALBUQUERQUE	NM	87131	BERNALILLO	USA	Biomedical Research and Research Training	002	14	1/29/2015	COMPETING CONTINUATION	$314,854
2015	2014	UNIVERSITY OF NEW MEXICO (THE)	1 UNIVERSITY OF NEW MEXICO	ALBUQUERQUE	NM	87131	BERNALILLO	USA	Biomedical Research and Research Training	001	13	1/26/2015	NON-COMPETING CONTINUATION	$0
2015	2014	UNIVERSITY OF NEW MEXICO (THE)	1 UNIVERSITY OF NEW MEXICO	ALBUQUERQUE	NM	87131	BERNALILLO	USA	Biomedical Research and Research Training	000	13	1/26/2015	SUPPLEMENT FOR EXPANSION	$0
														Subtotal = $314,854

Issue Date FY: 2014 ( Subtotal = $355,177 )
2014	2014	UNIVERSITY OF NEW MEXICO (THE)	1 UNIVERSITY OF NEW MEXICO	ALBUQUERQUE	NM	87131	BERNALILLO	USA	Biomedical Research and Research Training	001	13	2/6/2014	SUPPLEMENT FOR EXPANSION	$53,177
2014	2014	UNIVERSITY OF NEW MEXICO (THE)	1 UNIVERSITY OF NEW MEXICO	ALBUQUERQUE	NM	87131	BERNALILLO	USA	Biomedical Research and Research Training	000	13	11/27/2013	NON-COMPETING CONTINUATION	$271,800
2014	2014	UNIVERSITY OF NEW MEXICO (THE)	1 UNIVERSITY OF NEW MEXICO	ALBUQUERQUE	NM	87131	BERNALILLO	USA	Biomedical Research and Research Training	002	13	3/18/2014	NON-COMPETING CONTINUATION	$30,200
														Subtotal = $355,177

Issue Date FY: 2013 ( Subtotal = $291,430 )
2013	2013	UNIVERSITY OF NEW MEXICO (THE)	1 UNIVERSITY OF NEW MEXICO	ALBUQUERQUE	NM	87131	BERNALILLO	USA	Biomedical Research and Research Training	000	12	11/19/2012	NON-COMPETING CONTINUATION	$271,800
2013	2013	UNIVERSITY OF NEW MEXICO (THE)	1 UNIVERSITY OF NEW MEXICO	ALBUQUERQUE	NM	87131	BERNALILLO	USA	Biomedical Research and Research Training	001	12	6/28/2013	NON-COMPETING CONTINUATION	$19,630
														Subtotal = $291,430

Issue Date FY: 2012 ( Subtotal = $321,213 )
2012	2012	UNIVERSITY OF NEW MEXICO (THE)	1 UNIVERSITY OF NEW MEXICO	ALBUQUERQUE	NM	87131	BERNALILLO	USA	Biomedical Research and Research Training	000	11	12/2/2011	NON-COMPETING CONTINUATION	$289,092
2012	2012	UNIVERSITY OF NEW MEXICO (THE)	1 UNIVERSITY OF NEW MEXICO	ALBUQUERQUE	NM	87131	BERNALILLO	USA	Biomedical Research and Research Training	001	11	3/1/2012	NON-COMPETING CONTINUATION	$32,121
														Subtotal = $321,213

Issue Date FY: 2011 ( Subtotal = $315,819 )
2011	2011	UNIVERSITY OF NEW MEXICO (THE)	1 UNIVERSITY OF NEW MEXICO	ALBUQUERQUE	NM	87131	BERNALILLO	USA	Biomedical Research and Research Training	004	10	6/9/2011	SUPPLEMENT FOR EXPANSION	$14,402
2011	2011	UNIVERSITY OF NEW MEXICO (THE)	1 UNIVERSITY OF NEW MEXICO	ALBUQUERQUE	NM	87131	BERNALILLO	USA	Biomedical Research and Research Training	000	10	12/6/2010	COMPETING CONTINUATION	$301,417
2011	2010	UNIVERSITY OF NEW MEXICO (THE)	1 UNIVERSITY OF NEW MEXICO	ALBUQUERQUE	NM	87131	BERNALILLO	USA	Biomedical Research and Research Training	002	9	12/6/2010	SUPPLEMENT FOR EXPANSION	$0
2011	2009	UNIVERSITY OF NEW MEXICO (THE)	1 UNIVERSITY OF NEW MEXICO	ALBUQUERQUE	NM	87131	BERNALILLO	USA	Biomedical Research and Research Training	003	9	12/6/2010	SUPPLEMENT FOR EXPANSION	$0
2011	2009	UNIVERSITY OF NEW MEXICO (THE)	1 UNIVERSITY OF NEW MEXICO	ALBUQUERQUE	NM	87131	BERNALILLO	USA	Biomedical Research and Research Training	001	9	12/6/2010	NON-COMPETING CONTINUATION	$0
														Subtotal = $315,819

Issue Date FY: 2010 ( Subtotal = $87,681 )
2010	2010	UNIVERSITY OF NEW MEXICO (THE)	1 UNIVERSITY OF NEW MEXICO	ALBUQUERQUE	NM	87131	BERNALILLO	USA	Biomedical Research and Research Training	001	9	3/8/2010	SUPPLEMENT FOR EXPANSION	$87,681
2010	2009	UNIVERSITY OF NEW MEXICO (THE)	1 UNIVERSITY OF NEW MEXICO	ALBUQUERQUE	NM	87131	BERNALILLO	USA	Biomedical Research and Research Training	002	9	3/8/2010	SUPPLEMENT FOR EXPANSION	$0
2010	2009	UNIVERSITY OF NEW MEXICO (THE)	1 UNIVERSITY OF NEW MEXICO	ALBUQUERQUE	NM	87131	BERNALILLO	USA	Biomedical Research and Research Training	000	9	3/8/2010	NON-COMPETING CONTINUATION	$0
														Subtotal = $87,681

Issue Date FY: 2009 ( Subtotal = $359,795 ) (Continued on the next page)
2009	2009	UNIVERSITY OF NEW MEXICO (THE)	1 UNIVERSITY OF NEW MEXICO	ALBUQUERQUE	NM	87131	BERNALILLO	USA	Trans-NIH Recovery Act Research Support	002	9	8/28/2009	SUPPLEMENT FOR EXPANSION	$58,175
Grand Total All Awards = $6,373,953

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Genetic Regulation of Muscle Fiber Diversity

Award Number: R01GM061738

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 05/01/2001

PERIOD OF PERFORMANCE END DATE: 02/29/2024

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