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Forecasting Trachoma Control - Diversity Supplement

Award Number: R01EY025350
ORGANIZATION: NATIONAL EYE INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 06/01/2016
PERIOD OF PERFORMANCE END DATE: 05/31/2028

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Forecasting Trachoma Control - Diversity Supplement - PROJECT SUMMARY/ABSTRACT Annual mass azithromycin distribution dramatically reduces the prevalence strains of Chlamydia trachomatis that lead to blindness. Current World Health Organization guidelines indicate that annual mass azithromycin distribution should be continued until district-level prevalence of the clinical sign of trachoma, trachomatous inflammation-follicular (TF), drops below 5%. However, TF does not correlate well with true prevalence and there is no gold standard to detect this. Here, we propose that a Hidden Markov Model 1) will identify the true prevalence in hypo-endemic areas that can be used as a signal that the mass azithromycin protocol was successful and an indicator to stop antibiotics and 2) identify hyperendemic areas that the protocol has not been successful to change the treatment regimen. We anticipate that results will provide evidence to support altering the modification of current interventions for trachoma.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $443,659 )
2025	2025	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94103	SAN FRANCISCO	USA	Vision Research	000	7	5/15/2025	NON-COMPETING CONTINUATION	$403,750
2025	2025	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94103	SAN FRANCISCO	USA	Vision Research	003	7	7/31/2025	SUPPLEMENT FOR EXPANSION	$39,909
2025	2024	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94103	SAN FRANCISCO	USA	Vision Research	001	6	5/29/2025	TERMINATION	$0
2025	2024	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94103	SAN FRANCISCO	USA	Vision Research	002	6	7/10/2025	OTHER REVISION	$0
														Subtotal = $443,659

Issue Date FY: 2024 ( Subtotal = $463,423 )
2024	2024	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94103	SAN FRANCISCO	USA	Vision Research	001	5	5/16/2024	SUPPLEMENT FOR EXPANSION	$0
2024	2024	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94103	SAN FRANCISCO	USA	Vision Research	002	6	5/21/2024	NON-COMPETING CONTINUATION	$403,750
2024	2024	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Vision Research	000	5	12/12/2023	SUPPLEMENT FOR EXPANSION	$52,071
2024	2024	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94103	SAN FRANCISCO	USA	Vision Research	003	6	6/7/2024	SUPPLEMENT FOR EXPANSION	$7,602
														Subtotal = $463,423

Issue Date FY: 2023 ( Subtotal = $403,612 )
2023	2023	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Vision Research	001	5	5/3/2023	COMPETING CONTINUATION	$403,750
2023	2019	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Vision Research	000	4	11/1/2022	NON-COMPETING CONTINUATION	-$138
														Subtotal = $403,612

Issue Date FY: 2021 ( Subtotal = $0 )
2021	2019	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Vision Research	000	4	4/15/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2019 ( Subtotal = $393,570 )
2019	2019	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Vision Research	000	4	4/19/2019	NON-COMPETING CONTINUATION	$393,570
														Subtotal = $393,570

Issue Date FY: 2018 ( Subtotal = $396,495 )
2018	2018	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 420	SAN FRANCISCO	CA	94103	SAN FRANCISCO	USA	Vision Research	000	3	4/23/2018	NON-COMPETING CONTINUATION	$396,495
														Subtotal = $396,495

Issue Date FY: 2017 ( Subtotal = $399,420 )
2017	2017	UNIVERSITY OF CALIFORNIA, SAN FRANCISCO	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94103	SAN FRANCISCO	USA	Vision Research	001	2	7/10/2017	NON-COMPETING CONTINUATION	$39,942
2017	2017	UNIVERSITY OF CALIFORNIA, SAN FRANCISCO	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94103	SAN FRANCISCO	USA	Vision Research	000	2	5/1/2017	NON-COMPETING CONTINUATION	$359,478
														Subtotal = $399,420

Issue Date FY: 2016 ( Subtotal = $399,420 )
2016	2016	UNIVERSITY OF CALIFORNIA-SAN FRANCISCO	BOX 0812	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Vision Research	000	1	4/28/2016	NEW	$399,420
														Subtotal = $399,420

Grand Total All Awards = $2,899,599

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Forecasting Trachoma Control - Diversity Supplement

Award Number: R01EY025350

ORGANIZATION: NATIONAL EYE INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 06/01/2016

PERIOD OF PERFORMANCE END DATE: 05/31/2028

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