Friday, April 26, 2024 4/26/2024

Real-Time Assessment of Lung Structure and Function in CF Patients using Electrical Impedance Tomography

Award Number: R01EB026710
ORGANIZATION: NATIONAL INSTITUTE Of BIOMEDICAL IMAGING & BIOENGINEERING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

Group Awards By Issue Date FY or Funding FY:

View Award Abstract

Project Summary Cystic fibrosis is a genetic lung disease marked by progressive decline in lung structure and function. Use of the gold standards of CT scans and pulmonary function tests (PFT's) to assess lung structure and function, respectively, are hindered by the ionizing radiation applied to the patient in CT scanning, and the inability of very young patients to perform PFTs. The goal of this research is to determine whether electrical impedance tomography (EIT) can provide sensitive measures of changes in lung structure and function in CF patients of all ages. To test this hypothesis we will study the ability of EIT images and derived measures to detect structural changes through a 3 year longitudinal study and changes pre and post-treatment for an acute PE. This project is part of a long term goal to develop an EIT system for imaging patients with chronic lung disease. EIT is a noninvasive, non-ionizing functional imaging technique in which images are formed from voltages measured on electrodes on the body arising from imperceptible applied currents. Since EIT is a safe and portable technology with no damaging side effects, it can be used as needed. This research builds on the results of a previous grant in which a strong correlation was demonstrated between EIT-derived measures of pulmonary function and PFT output measures in CF patients, and the ability to identify air trapping was demonstrated. In this work, novel EIT hardware and algorithms will be developed to obtain 3-D reconstructions with current patterns that provide the highest signal-to-noise ratio (SNR) on all electrodes. The design and validation of this improved high performance EIT system is the first specific aim. The second specific aim is to develop algorithms in 3-D for the computation of regional aeration and ventilation perfusion ratio (V/Q) maps in 3-D, and for the identification and quantification of regions of air trapping and consolidation. The third aim is to determine the ability of EIT to identify functional and structural physiological changes that occur with disease progression through a clinical study with the following subaims: to determine whether EIT can serve as a selective alternative for CT to identify regions of air trapping and consolidation, whether EIT can provide clinically useful information about response to treatment for an acute PE, and whether EIT can provide longitudinal information about structural changes in the lung. 1


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2023 ( Subtotal = $0 )
2023	2022	COLORADO STATE UNIVERSITY	601 S HOWES ST	FORT COLLINS	CO	80521	LARIMER	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	001	4	7/24/2023	NON-COMPETING CONTINUATION	$0
2023	2021	COLORADO STATE UNIVERSITY	601 S HOWES ST	FORT COLLINS	CO	80521	LARIMER	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	2	1/20/2023	SUPPLEMENT FOR EXPANSION	$0
														Subtotal = $0

Issue Date FY: 2022 ( Subtotal = $524,470 )
2022	2022	COLORADO STATE UNIVERSITY	601 S HOWES ST	FORT COLLINS	CO	80521	LARIMER	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	001	4	8/25/2022	NON-COMPETING CONTINUATION	$524,470
2022	2021	COLORADO STATE UNIVERSITY	601 S HOWES ST	FORT COLLINS	CO	80521	LARIMER	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	3	11/10/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $524,470

Issue Date FY: 2021 ( Subtotal = $1,327,154 )
2021	2021	COLORADO STATE UNIVERSITY	601 S HOWES ST	FORT COLLINS	CO	80521	LARIMER	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	002	2	9/8/2021	SUPPLEMENT FOR EXPANSION	$0
2021	2021	COLORADO STATE UNIVERSITY	601 S HOWES ST	FORT COLLINS	CO	80521	LARIMER	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	001	2	3/11/2021	SUPPLEMENT FOR EXPANSION	$793,097
2021	2021	COLORADO STATE UNIVERSITY	601 S HOWES ST	FORT COLLINS	CO	80521	LARIMER	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	003	3	9/18/2021	NON-COMPETING CONTINUATION	$534,057
2021	2020	COLORADO STATE UNIVERSITY	601 S HOWES ST	FORT COLLINS	CO	80521	LARIMER	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	2	12/11/2020	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,327,154

Issue Date FY: 2020 ( Subtotal = $596,023 )
2020	2020	COLORADO STATE UNIVERSITY	601 S HOWES ST	FORT COLLINS	CO	80521	LARIMER	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	2	1/14/2020	NON-COMPETING CONTINUATION	$596,023
														Subtotal = $596,023

Issue Date FY: 2019 ( Subtotal = $625,529 )
2019	2019	COLORADO STATE UNIVERSITY	601 S HOWES ST	FORT COLLINS	CO	80521	LARIMER	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	1	3/29/2019	NEW	$625,529
														Subtotal = $625,529

Grand Total All Awards = $3,073,176

Top

All Categories

About

Search

Reports

Data Submission

Award Information

Real-Time Assessment of Lung Structure and Function in CF Patients using Electrical Impedance Tomography

Award Number: R01EB026710

ORGANIZATION: NATIONAL INSTITUTE Of BIOMEDICAL IMAGING & BIOENGINEERING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer