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3D real-time super-resolution cavitation mapping in laser lithotripsy of urinary stone disease

Award Number: R01DK139109
ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/01/2024
PERIOD OF PERFORMANCE END DATE: 01/31/2025

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3D real-time super-resolution cavitation mapping in laser lithotripsy of urinary stone disease - Laser lithotripsy (LL) is commonly used for kidney stone treatment, with cavitation playing a crucial role in stone fragmentation. However, the relationship between cavitation activities and stone damage remains unclear. This supplement study by Anthony DiSpirito will utilize deep learning to predict stone damage based on passive cavitation mapping (PCM) signals. A three-dimensional PCM system will be employed, along with B-mode Ultrasound (US) for data acquisition. Deep learning enables the optimization of LL procedures by automating feature selection and identifying key factors driving stone damage. Our approach will offer valuable insights into medical practice, advancing the efficacy of LL treatments. We will adopt deep learning module combined with cavitation activities information, and we can better predict the potential damaged induced by bubble collapsing. Our result will also demonstrate the strong correlation between bubble collapsing information with stone crater damage. This approach can also be further explored with more sophisticated scenarios and clinical applications.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $602,441 )
2025	2025	DUKE UNIVERSITY	2200 W MAIN ST	DURHAM	NC	27705	DURHAM	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	2	4/22/2025	NON-COMPETING CONTINUATION	$602,441
2025	2024	DUKE UNIVERSITY	2200 W MAIN ST	DURHAM	NC	27705	DURHAM	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	1	4/29/2025	TERMINATION	$0
														Subtotal = $602,441

Issue Date FY: 2024 ( Subtotal = $630,869 )
2024	2024	DUKE UNIVERSITY	2200 W MAIN ST	DURHAM	NC	27705	DURHAM	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	1	7/19/2024	NEW	$0
2024	2024	DUKE UNIVERSITY	2200 W MAIN ST	DURHAM	NC	27705	DURHAM	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	002	1	8/21/2024	SUPPLEMENT FOR EXPANSION	$37,462
2024	2024	DUKE UNIVERSITY	2200 W MAIN ST	DURHAM	NC	27705	DURHAM	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	1	3/28/2024	NEW	$593,407
														Subtotal = $630,869

Grand Total All Awards = $1,233,310

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3D real-time super-resolution cavitation mapping in laser lithotripsy of urinary stone disease

Award Number: R01DK139109

ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/01/2024

PERIOD OF PERFORMANCE END DATE: 01/31/2025

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