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Catecholamine Neurons and Metabolic Controls

Award Number: R01DK114187
ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 03/01/2018
PERIOD OF PERFORMANCE END DATE: 01/31/2024

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Catecholamine Neurons and Metabolic Controls - Project Summary Glucose is the required metabolic fuel for the brain. Quantities of stored glucose (glycogen) in the brain are adequate to maintain brain function and survival for only a few minutes. Therefore, glucose must be monitored constantly in order to control diverse behavioral, endocrine and autonomic responses that ensure delivery of glucose from the blood. Mechanisms that detect brain glucose deficit and elicit protective responses, referred to as counter-regulatory responses (CRRs), that mobilize and replenish the brain's glucose supply are of vital importance for survival. These responses include stimulation of appetite, increased glucocorticoid and adrenal medullary secretion and others. Studies employing molecular neurosurgery with targeted immunotoxins, in situ hybridization, gene silencing and CNO/DREAAD technology all support the essential involvement of catecholamine (CA) neuron subpopulations in elicitation of CRRs. However, an obstacle to research in this area has been that CA neurons in the same general areas of the hindbrain that house the glucoregulatory CA neurons are involved in multiple and equally critical homeostatic functions that are not directly glucoregulatory (such as cardiovascular, respiratory, and neuroendocrine controls). However, new data and techniques are available that will allow us to specifically characterize and probe the distinct functions of the glucoregulatory CA subgroups and possibly to identify the underlying causes of their dysregulation in hypoglycemia associated autonomic failure (HAAF), a potentially lethal condition that constantly threatens diabetic patients on insulin therapy. Using a variety of technical approaches, we will attempt to reveal peptides that act as co-transmitters for CA neurons involved in specific CRRs (feeding, glucocorticoid and adrenal medullary secretion), as well as identifying the glucosensing mechanisms they express. We will also evaluate the effect of acute and recurrent glucoprivation on these mechanisms.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = -$127 )
2024	2021	WASHINGTON STATE UNIVERSITY	240 FRENCH ADMINISTRATION BLDG	PULLMAN	WA	99164	WHITMAN	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	4	6/11/2024	NON-COMPETING CONTINUATION	-$127
														Subtotal = -$127

Issue Date FY: 2023 ( Subtotal = $0 )
2023	2021	WASHINGTON STATE UNIVERSITY	240 FRENCH ADMINISTRATION BLDG	PULLMAN	WA	99164	WHITMAN	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	4	12/28/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2021 ( Subtotal = $451,986 )
2021	2021	WASHINGTON STATE UNIVERSITY	240 FRENCH ADMINISTRATION BLDG	PULLMAN	WA	99164	WHITMAN	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	4	2/2/2021	NON-COMPETING CONTINUATION	$451,986
2021	2021	WASHINGTON STATE UNIVERSITY	240 FRENCH ADMINISTRATION BLDG	PULLMAN	WA	99164	WHITMAN	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	4	7/13/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $451,986

Issue Date FY: 2020 ( Subtotal = $451,986 )
2020	2020	WASHINGTON STATE UNIVERSITY	240 FRENCH ADMINISTRATION BLDG	PULLMAN	WA	99164	WHITMAN	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	3	3/12/2020	NON-COMPETING CONTINUATION	$451,986
														Subtotal = $451,986

Issue Date FY: 2019 ( Subtotal = $451,986 )
2019	2019	WASHINGTON STATE UNIVERSITY	240 FRENCH ADMINISTRATION BLDG	PULLMAN	WA	99164	WHITMAN	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	2	1/9/2019	NON-COMPETING CONTINUATION	$451,986
														Subtotal = $451,986

Issue Date FY: 2018 ( Subtotal = $451,986 )
2018	2018	WASHINGTON STATE UNIVERSITY	240 FRENCH ADMINISTRATION BLDG	PULLMAN	WA	99164	WHITMAN	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	1	2/12/2018	NEW	$451,986
														Subtotal = $451,986

Grand Total All Awards = $1,807,817

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Catecholamine Neurons and Metabolic Controls

Award Number: R01DK114187

ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 03/01/2018

PERIOD OF PERFORMANCE END DATE: 01/31/2024

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