Thursday, February 19, 2026 2/19/2026

Epigenetic regulation of adipose tissue distribution in women

Award Number: R01DK107009
ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 06/28/2016
PERIOD OF PERFORMANCE END DATE: 05/31/2021

Group Awards By:

View Award Description

Epigenetic regulation of adipose tissue distribution in women - ¿ DESCRIPTION (provided by applicant): In 1954 Vague identified central adiposity as a key determinant of several common chronic diseases including diabetes, myocardial infarction, hypertension and stroke. Vague contrasted the 'apple' pattern with metabolically beneficial gluteal - femoral adipose tissue (pears). This observation spawned more than a half century of clinical and laboratory investigation yet, there is still a major gap in our knowledge regarding th molecular underpinnings of adipose tissue patterning. It is clear that the relationship between adiposity and cardiovascular and diabetes disease risk is tightly related to fat patterning (apple vs. pear). In this regard, obese women who have a preponderance of abdominal subcutaneous fat (apple-shaped) have a higher risk of developing insulin resistance, diabetes and CVD relative to women who carry their excess weight in gluteal/thigh adipose tissue (pear-shaped). This proposal addresses the fundamental mechanisms associated with depot specific adipose function directly in humans. Our preliminary published and new unpublished studies support the hypothesis that fat depot specific gene expression and associated epigenetic signatures are maintained when abdominal vs. gluteal pre-adipocytes are cultured in vitro. The proposed new experiments will extend these studies to reveal genome-wide differences in epigenetic marks in adipose tissue and adipocytes from both men and women. We will also investigate the different gene expression patterns and associated epigenetic marks that define the pear vs. apple body type of the American adult female. We will uncover new fundamental molecular signatures and processes that are relevant to development of insulin resistance, diabetes and cardiovascular disease.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2022 ( Subtotal = $0 )
2022	2019	ADVENTIST HEALTH SYSTEM/SUNBELT, INC.	601 E ROLLINS ST	ORLANDO	FL	32803	ORANGE	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	4	11/2/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2019 ( Subtotal = $554,419 )
2019	2019	ADVENTIST HEALTH SYSTEM/SUNBELT, INC.	601 E ROLLINS ST	ORLANDO	FL	32803	ORANGE	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	4	6/19/2019	NON-COMPETING CONTINUATION	$554,419
														Subtotal = $554,419

Issue Date FY: 2018 ( Subtotal = $566,443 )
2018	2018	ADVENTIST HEALTH SYSTEM/SUNBELT, INC.	601 E ROLLINS ST	ORLANDO	FL	32803	ORANGE	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	3	6/14/2018	NON-COMPETING CONTINUATION	$566,443
														Subtotal = $566,443

Issue Date FY: 2017 ( Subtotal = $613,815 )
2017	2017	ADVENTIST HEALTH SYSTEM/SUNBELT, INC.	601 E ROLLINS ST	ORLANDO	FL	32803	ORANGE	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	2	6/29/2017	NON-COMPETING CONTINUATION	$613,815
														Subtotal = $613,815

Issue Date FY: 2016 ( Subtotal = $644,939 )
2016	2016	ADVENTIST HEALTH SYSTEM/SUNBELT INC	601 EAST ROLLINS STREET	ORLANDO	FL	32803	ORANGE	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	1	6/28/2016	NEW	$644,939
														Subtotal = $644,939

Grand Total All Awards = $2,379,616

Top

All Categories

About

Search

Reports

Data Submission

Award Information

Epigenetic regulation of adipose tissue distribution in women

Award Number: R01DK107009

ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 06/28/2016

PERIOD OF PERFORMANCE END DATE: 05/31/2021

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer