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A decentralized macro and micro gene-by-environment interaction analysis of substance use behavior and its brain biomarkers

Award Number: R01DA049238
ORGANIZATION: NATIONAL INSTITUTE ON DRUG ABUSE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Abstract Wide-spread data sharing has started to permeate the brain imaging community from funders to researchers. However, in recent years there have also been some concerns raised regarding ethical issues related to privacy and data ownership among others. In the parent award we are leveraging and extending a privacy preserving decentralized data sharing platform called COINSTAC to perform a study of gene-by-environmental effects by pooling together data from across the world, some of which is unable to be openly shared. In this supplement we will study various bioethical issues related to different data sharing strategies. This will include calculating risk scores from existing data to evaluate the effectiveness of machine learning to potentially reidentify from similar or different data types, a detailed survey of various policy makers and stakeholders including researchers, federal employees, IRB members, and more, and finally the development of a forward looking white paper addressing both privacy, policy, and regulatory aspects which attempts to frame the various aspects that arise in the contact of the spectrum of data sharing approaches including fully open, ‘trust’ based via data usage agreements, privacy preserving via tools like COINSTAC, and more. The outcomes of this supplement will provide a useful guide for the field going forward and also provide initial data necessary to develop a larger scale project on these topics going forward.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2023 ( Subtotal = $542,744 )
2023	2023	GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION INC	58 EDGEWOOD AVE NE	ATLANTA	GA	30303	FULTON	USA	Drug Abuse and Addiction Research Programs	000	5	6/15/2023	NON-COMPETING CONTINUATION	$542,744
														Subtotal = $542,744

Issue Date FY: 2022 ( Subtotal = $542,744 )
2022	2022	GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC.	58 EDGEWOOD AVE NE 3RD FL	ATLANTA	GA	30303	FULTON	USA	Drug Abuse and Addiction Research Programs	000	4	6/14/2022	NON-COMPETING CONTINUATION	$542,744
														Subtotal = $542,744

Issue Date FY: 2021 ( Subtotal = $542,744 )
2021	2021	GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC.	58 EDGEWOOD AVE NE 3RD FL	ATLANTA	GA	30303	FULTON	USA	Drug Abuse and Addiction Research Programs	000	3	7/2/2021	NON-COMPETING CONTINUATION	$542,744
														Subtotal = $542,744

Issue Date FY: 2020 ( Subtotal = $691,037 )
2020	2020	GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC.	58 EDGEWOOD AVE NE 3RD FL	ATLANTA	GA	30303	FULTON	USA	Drug Abuse and Addiction Research Programs	003	2	7/24/2020	SUPPLEMENT FOR EXPANSION	$149,834
2020	2020	GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC.	58 EDGEWOOD AVE NE 3RD FL	ATLANTA	GA	30303	FULTON	USA	Drug Abuse and Addiction Research Programs	002	2	6/18/2020	NON-COMPETING CONTINUATION	$541,203
2020	2019	GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC.	58 EDGEWOOD AVE NE 3RD FL	ATLANTA	GA	30303	FULTON	USA	Drug Abuse and Addiction Research Programs	001	1	2/6/2020	NEW	$551,746
2020	2019	GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC.	58 EDGEWOOD AVE NE 3RD FL	ATLANTA	GA	30303	FULTON	USA	Drug Abuse and Addiction Research Programs	000	1	2/5/2020	NEW	-$551,746
														Subtotal = $691,037

Issue Date FY: 2019 ( Subtotal = $551,746 )
2019	2019	GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC.	58 EDGEWOOD AVE NE 3RD FL	ATLANTA	GA	30303	FULTON	USA	Drug Abuse and Addiction Research Programs	000	1	9/3/2019	NEW	$551,746
														Subtotal = $551,746

Grand Total All Awards = $2,871,015

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A decentralized macro and micro gene-by-environment interaction analysis of substance use behavior and its brain biomarkers

Award Number: R01DA049238

ORGANIZATION: NATIONAL INSTITUTE ON DRUG ABUSE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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