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AMPLIFIed muscle mass in older cancer survivors enrolled in a diet-exercise program

Award Number: R01CA246695
ORGANIZATION: NATIONAL CANCER INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 12/09/2019
PERIOD OF PERFORMANCE END DATE: 11/30/2025

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AMPLIFIed muscle mass in older cancer survivors enrolled in a diet-exercise program - We propose to add the measurement of muscle mass to an already funded program project grant. Rapid declines in physical functioning often occur after the diagnosis of cancer, especially among older cancer survivors; however, a handful of diet and exercise interventions have been found to ameliorate these losses. The contribution of muscle mass and changes in muscle mass in older men and women, particularly those who have survived cancer is not well characterized, partly due to the inability to directly and accurately quantify skeletal muscle mass and reliance on assessments of lean mass as a surrogate. The Adapting MultiPLe behavior Interventions that eFfectively Improve (AMPLIFI) Cancer Survivor Health (1P01CA22997) is aimed at testing three distinct lifestyle interventions among 652 older, inactive, overweight or obese cancer survivors, a large proportion of whom will be minority and rural. The interventions include: 1) a 6-month dietary intervention aimed at improving diet quality and weight loss, as well as preserving lean body mass; 2) a 6-month intervention that is aimed at promoting aerobic physical activity; and 3) a 12-month diet and exercise intervention that combines both diet and exercise simultaneously (and effects will be evaluated against the combination of interventions 1 and 2 in sequence). Visiting nurses will assess physical function and perform phlebotomy at home health assessments scheduled at baseline and every six months; participants also will complete surveys that assess diet, physical activity and overall quality of life. We propose to measure the effects of these interventions on muscle mass using the novel D3-creatine (D3Cr) dilution method. We have demonstrated that this non- invasive method can be implemented in a large cohort study (MrOS) and that D3Cr muscle mass is strongly associated with functional capacity and risk of disability and that age- associated decreases in muscle mass are associated with slower gait speed and decreased strength. These associations were not observed using DXA derived lean mass. Subjects will ingest a 60 mg capsule of D3Cr and produce a fasting urine sample 48 – 96 hours later for the assessment of D3-Creatinine enrichment to determine creatine pool size and, because 98% of total body creatine is found in muscle, muscle mass. For the first time, the relationship between changes in muscle mass resulting from exercise and weight loss and functional capacity and physical activity will be assessed in this at-risk population of older cancer survivors.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $243,505 )
2024	2024	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 201	BERKELEY	CA	94710	ALAMEDA	USA	Cancer Detection and Diagnosis Research	001	5	4/12/2024	NON-COMPETING CONTINUATION	$12,817
2024	2024	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 201	BERKELEY	CA	94710	ALAMEDA	USA	Cancer Detection and Diagnosis Research	002	5	4/16/2024	NON-COMPETING CONTINUATION	$0
2024	2024	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 201	BERKELEY	CA	94710	ALAMEDA	USA	Cancer Detection and Diagnosis Research	000	5	11/30/2023	NON-COMPETING CONTINUATION	$230,688
														Subtotal = $243,505

Issue Date FY: 2023 ( Subtotal = $317,835 )
2023	2023	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 201	BERKELEY	CA	94710	ALAMEDA	USA	Cancer Detection and Diagnosis Research	000	4	12/1/2022	NON-COMPETING CONTINUATION	$291,890
2023	2023	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 201	BERKELEY	CA	94710	ALAMEDA	USA	Cancer Detection and Diagnosis Research	001	4	3/15/2023	NON-COMPETING CONTINUATION	$25,945
														Subtotal = $317,835

Issue Date FY: 2022 ( Subtotal = $248,169 )
2022	2022	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 201	BERKELEY	CA	94710	ALAMEDA	USA	Cancer Detection and Diagnosis Research	001	3	5/19/2022	NON-COMPETING CONTINUATION	$20,260
2022	2022	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 220	BERKELEY	CA	94710	ALAMEDA	USA	Cancer Detection and Diagnosis Research	000	3	11/22/2021	NON-COMPETING CONTINUATION	$227,909
														Subtotal = $248,169

Issue Date FY: 2021 ( Subtotal = $265,904 )
2021	2021	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 220	BERKELEY	CA	94710	ALAMEDA	USA	Cancer Detection and Diagnosis Research	001	2	2/1/2021	NON-COMPETING CONTINUATION	$13,296
2021	2021	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 220	BERKELEY	CA	94710	ALAMEDA	USA	Cancer Detection and Diagnosis Research	000	2	12/1/2020	NON-COMPETING CONTINUATION	$252,608
														Subtotal = $265,904

Issue Date FY: 2020 ( Subtotal = $263,427 )
2020	2020	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 220	BERKELEY	CA	94710	ALAMEDA	USA	Cancer Detection and Diagnosis Research	000	1	12/9/2019	NEW	$263,427
														Subtotal = $263,427

Grand Total All Awards = $1,338,840

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AMPLIFIed muscle mass in older cancer survivors enrolled in a diet-exercise program

Award Number: R01CA246695

ORGANIZATION: NATIONAL CANCER INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 12/09/2019

PERIOD OF PERFORMANCE END DATE: 11/30/2025

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