Tuesday, April 23, 2024 4/23/2024

Mechanism of P73-dependent Tumor Suppression

Award Number: R01CA081237
ORGANIZATION: NATIONAL CANCER INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

Group Awards By Issue Date FY or Funding FY:

View Award Abstract

Project Summary/Abstract p73, a member of the p53 family of tumor suppressors, is expressed from two promoters: the upstream P1 promoter that produces TAp73 and the downstream P2 promoter that produces ¿Np73. Additionally, p73 is expressed as six isoforms (¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿) through alternative splicing between exon 11-13. As a transcription factor, we and others showed that TAp73 contains an activation domain similar to the first activation domain (AD1) in p53. We also identified a unique activation domain in ¿Np73. Thus, TAp73 and ¿Np73 are capable of inducing a distinct set of target genes. Consistent with its transcriptional activity, mice deficient in TAp73 are prone to spontaneous tumors and accelerated aging whereas mice deficient in ¿Np73 are prone to neurological defects. However, compared to TA and ¿N isoforms, very little is known about p73 C-terminal isoforms and their activities in vivo. Now, by using CRISPR-cas9 method to delete one or more exons in the p73 gene in cell lines and in mice, we are able to systematically study the role of p73 C-terminal isoforms in vitro and in vivo. Our preliminary data showed that various p73 C-terminal isoforms have distinct activities. Thus, we hypothesize that each p73 C-terminal isoform has a unique function in tumor suppression and longevity. To test this, we will determine: (1) C-terminal isoform-specific activities in cell growth and differentiation; (2) C-terminal isoform-specific activities in tumor suppression and longevity; (3) C-terminal isoform-specific effects on tumorigenesis in p53-deficient or mutant p53R270H knockin mice.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2022 ( Subtotal = $443,116 )
2022	2022	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Cancer Biology Research	000	23	1/18/2022	NON-COMPETING CONTINUATION	$406,946
2022	2022	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Cancer Biology Research	001	23	4/29/2022	NON-COMPETING CONTINUATION	$36,170
														Subtotal = $443,116

Issue Date FY: 2021 ( Subtotal = $452,162 )
2021	2021	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Cancer Biology Research	000	22	1/18/2021	NON-COMPETING CONTINUATION	$452,162
														Subtotal = $452,162

Issue Date FY: 2020 ( Subtotal = $452,162 )
2020	2020	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Cancer Biology Research	000	21	1/9/2020	NON-COMPETING CONTINUATION	$452,162
														Subtotal = $452,162

Issue Date FY: 2019 ( Subtotal = $438,596 )
2019	2019	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Cancer Biology Research	000	20	1/10/2019	NON-COMPETING CONTINUATION	$438,596
														Subtotal = $438,596

Issue Date FY: 2018 ( Subtotal = $452,160 )
2018	2018	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Cancer Biology Research	000	19	1/25/2018	COMPETING CONTINUATION	$452,160
														Subtotal = $452,160

Issue Date FY: 2017 ( Subtotal = $0 )
2017	2015	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Cancer Biology Research	000	18	8/2/2017	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2015 ( Subtotal = $304,560 )
2015	2015	UNIVERSITY OF CALIFORNIA	1850 RESEARCH PARK DRIVE	DAVIS	CA	95618	YOLO	USA	Cancer Biology Research	000	18	3/6/2015	NON-COMPETING CONTINUATION	$304,560
														Subtotal = $304,560

Issue Date FY: 2014 ( Subtotal = $295,423 )
2014	2014	UNIVERSITY OF CALIFORNIA	1850 RESEARCH PARK DRIVE	DAVIS	CA	95618	YOLO	USA	Cancer Biology Research	000	17	3/28/2014	NON-COMPETING CONTINUATION	$295,423
														Subtotal = $295,423

Issue Date FY: 2013 ( Subtotal = $286,286 )
2013	2013	UNIVERSITY OF CALIFORNIA	1441 RESEARCH PARK DRIVE	DAVIS	CA	95616	YOLO	USA	Cancer Biology Research	000	16	3/4/2013	NON-COMPETING CONTINUATION	$137,052
2013	2013	UNIVERSITY OF CALIFORNIA	1441 RESEARCH PARK DRIVE	DAVIS	CA	95616	YOLO	USA	Cancer Biology Research	001	16	7/1/2013	NON-COMPETING CONTINUATION	$149,234
														Subtotal = $286,286

Issue Date FY: 2012 ( Subtotal = $304,395 )
2012	2012	UNIVERSITY OF CALIFORNIA	1441 RESEARCH PARK DRIVE	DAVIS	CA	95616	YOLO	USA	Cancer Biology Research	000	15	3/22/2012	NON-COMPETING CONTINUATION	$304,395
														Subtotal = $304,395

Issue Date FY: 2011 ( Subtotal = $303,406 )
2011	2011	UNIVERSITY OF CALIFORNIA	1441 RESEARCH PARK DRIVE	DAVIS	CA	95616	YOLO	USA	Cancer Biology Research	000	14	4/8/2011	COMPETING CONTINUATION	$288,236
2011	2011	UNIVERSITY OF CALIFORNIA	1441 RESEARCH PARK DRIVE	DAVIS	CA	95616	YOLO	USA	Cancer Biology Research	001	14	5/19/2011	COMPETING CONTINUATION	$15,170
														Subtotal = $303,406

Issue Date FY: 2010 ( Subtotal = $303,406 )
2010	2010	UNIVERSITY OF CALIFORNIA	1441 RESEARCH PARK DRIVE	DAVIS	CA	95616	YOLO	USA	Trans-NIH Recovery Act Research Support	000	13	4/6/2010	NON-COMPETING CONTINUATION	$303,406
														Subtotal = $303,406

Issue Date FY: 2009 ( Subtotal = $302,253 )
2009	2009	UNIVERSITY OF CALIFORNIA	1441 RESEARCH PARK DRIVE	DAVIS	CA	95616	YOLO	USA	Trans-NIH Recovery Act Research Support	001	12	5/19/2009	COMPETING CONTINUATION	$302,253
2009	2008	UNIVERSITY OF CALIFORNIA	1441 RESEARCH PARK DRIVE	DAVIS	CA	95616	YOLO	USA	Cancer Biology Research	000	11	5/19/2009	NON-COMPETING CONTINUATION	$0
														Subtotal = $302,253

Issue Date FY: 2008 ( Subtotal = $291,851 )
2008	2008	UNIVERSITY OF CALIFORNIA	1441 RESEARCH PARK DRIVE	DAVIS	CA	95616	YOLO	USA	Cancer Biology Research	000	11	2/12/2008	NON-COMPETING CONTINUATION	$291,851
														Subtotal = $291,851

Issue Date FY: 2007 ( Subtotal = $291,531 )
2007	2007	UNIVERSITY OF CALIFORNIA	1441 RESEARCH PARK DRIVE	DAVIS	CA	95616	YOLO	USA	Cancer Biology Research	000	10	4/20/2007	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$291,531
														Subtotal = $291,531

Issue Date FY: 2006 ( Subtotal = $286,724 )
2006	2006	UNIVERSITY OF ALABAMA AT BIRMINGHAM	UAB STATION, CBB 990	BIRMINGHAM	AL	35294	JEFFERSON	USA	Cancer Biology Research	000	9	2/15/2006	NON-COMPETING CONTINUATION	$286,724
														Subtotal = $286,724

Issue Date FY: 2005 ( Subtotal = $293,625 )
2005	2005	UNIVERSITY OF ALABAMA AT BIRMINGHAM	UAB STATION, CBB 990	BIRMINGHAM	AL	35294	JEFFERSON	USA	Cancer Biology Research	000	8	3/1/2005	NON-COMPETING CONTINUATION	$293,625
														Subtotal = $293,625

Issue Date FY: 2004 ( Subtotal = $293,625 )
2004	2004	UNIVERSITY OF ALABAMA AT BIRMINGHAM	UAB STATION, CBB 990	BIRMINGHAM	AL	35294	JEFFERSON	USA	Cancer Biology Research	000	7	2/5/2004	COMPETING CONTINUATION	$293,625
														Subtotal = $293,625

Issue Date FY: 2003 ( Subtotal = $251,788 )
2003	2003	UNIVERSITY OF ALABAMA AT BIRMINGHAM	UAB STATION, CBB 990	BIRMINGHAM	AL	35294	JEFFERSON	USA	Cancer Biology Research	000	6		NON-COMPETING CONTINUATION	$251,788
														Subtotal = $251,788

Issue Date FY: 2002 ( Subtotal = $242,736 )
2002	2002	UNIVERSITY OF ALABAMA AT BIRMINGHAM	UAB STATION, CBB 990	BIRMINGHAM	AL	35294	JEFFERSON	USA	Cancer Biology Research	000	5	2/8/2002	NON-COMPETING CONTINUATION	$242,736
														Subtotal = $242,736

Issue Date FY: 2001 ( Subtotal = $241,469 )
2001	2001	MEDICAL COLLEGE OF GEORGIA, RESEARCH INSTITUTE	RESEARCH INSTITUTE	AUGUSTA	GA	30912	RICHMOND	USA	Cancer Biology Research	000	3	3/1/2001	NON-COMPETING CONTINUATION	$241,469
														Subtotal = $241,469

Issue Date FY: 2000 ( Subtotal = $234,437 )
2000	2000	AUGUSTA UNIVERSITY RESEARCH INSTITUTE, INC	1120 15TH STREET	AUGUSTA	GA	30912	RICHMOND	USA	Cancer Biology Research	000	2	2/16/2000	NON-COMPETING CONTINUATION	$234,437
														Subtotal = $234,437

Issue Date FY: 1999 ( Subtotal = $200,074 )
1999	1999	AUGUSTA UNIVERSITY RESEARCH INSTITUTE, INC	1120 15TH STREET	AUGUSTA	GA	30912	RICHMOND	USA	Cancer Biology Research	000	1	4/30/1999	NEW	$200,074
														Subtotal = $200,074

Grand Total All Awards = $6,965,785

Top

All Categories

About

Search

Reports

Data Submission

Award Information

Mechanism of P73-dependent Tumor Suppression

Award Number: R01CA081237

ORGANIZATION: NATIONAL CANCER INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer