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Oligodendrocyte heterogeneity in Alzheimer' s disease

Award Number: R01AG071683
ORGANIZATION: NATIONAL INSTITUTE ON AGING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 04/01/2021
PERIOD OF PERFORMANCE END DATE: 03/31/2027

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Oligodendrocyte heterogeneity in Alzheimer' s disease - Project Summary/Abstract Neurodegenerative disease mechanisms encompassing Alzheimer’s disease (AD) are complex and have remained largely unknown to date despite the identification of risk factors and genetic mutations associated with the disease. Oligodendrocytes (ODCs) have critical roles in the central nervous system where they ensheath axons to allow rapid saltatory conduction and also provide metabolic support to neurons. Although a largely homogeneous oligodendrocyte population is thought to execute these functions throughout the brain, recent reports suggests that ODCs are highly diversified cell populations in the brain. Using systems biology approach, that integrates multi-omics data from human pathological specimens and mouse models of AD, this project aims to generate single-cell resolution genome-wide maps of transcriptional and regulatory networks in ODCs associated with AD. The project represents a major advance in the field by taking a comprehensive approach to data-driven discovery to identify highly conserved regulatory programs of AD. In parallel, the project aims to understand the role of sterol regulatory-element binding proteins (SREBPs) in AD using functional genomic approaches. Finally, the project will identify novel cell-type specific transcriptional regulators of AD using cutting edge approaches to data science.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $0 )
2026	2025	UNIVERSITY OF CALIFORNIA IRVINE	160 ALDRICH HALL	IRVINE	CA	92697	ORANGE	USA	Aging Research	000	3	1/20/2026	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2025 ( Subtotal = $605,965 )
2025	2025	UNIVERSITY OF CALIFORNIA IRVINE	160 ALDRICH HALL	IRVINE	CA	92697	ORANGE	USA	Aging Research	000	3	3/19/2025	NON-COMPETING CONTINUATION	$556,500
2025	2025	UNIVERSITY OF CALIFORNIA IRVINE	160 ALDRICH HALL	IRVINE	CA	92697	ORANGE	USA	Aging Research	001	3	6/10/2025	NON-COMPETING CONTINUATION	$49,465
														Subtotal = $605,965

Issue Date FY: 2024 ( Subtotal = $1,375,480 )
2024	2024	UNIVERSITY OF CALIFORNIA IRVINE	160 ALDRICH HALL	IRVINE	CA	92697	ORANGE	USA	Aging Research	000	2	3/15/2024	EXTENSION WITH OR WITHOUT FUNDS	$550,098
2024	2024	UNIVERSITY OF CALIFORNIA IRVINE	160 ALDRICH HALL	IRVINE	CA	92697	ORANGE	USA	Aging Research	002	2	8/12/2024	EXTENSION WITH OR WITHOUT FUNDS	$761,425
2024	2024	UNIVERSITY OF CALIFORNIA IRVINE	160 ALDRICH HALL	IRVINE	CA	92697	ORANGE	USA	Aging Research	001	2	7/10/2024	EXTENSION WITH OR WITHOUT FUNDS	$63,957
														Subtotal = $1,375,480

Grand Total All Awards = $1,981,445

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Oligodendrocyte heterogeneity in Alzheimer' s disease

Award Number: R01AG071683

ORGANIZATION: NATIONAL INSTITUTE ON AGING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 04/01/2021

PERIOD OF PERFORMANCE END DATE: 03/31/2027

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