The Colorado Department of Public Health and Environment (CDPHE) is submitting an application in response to Funding Opportunity Number CDC-RFA-CK24-2401, Emerging Infections Programs (EIP). CDPHE has been a funded EIP site since 2000. The purpose of this application is to maintain, enhance, and improve existing EIP work in Colorado. The primary catchment area for this application is the five-county Denver metropolitan area, with additional catchment areas based on individual projects. Colorado’s proposal includes the following activities: Infrastructure and Data Modernization, Surveillance and Reporting 1 and 2, RESP-NET (including FluSurvNET, RSV-NET, and COVID-NET), Active Bacterial Core Surveillance (ABCs), Pertussis, Picornavirus, Foodborne Disease Active Surveillance Network (FoodNet), Healthcare Associated Infections - Community Interface (HAIC), Prion Disease, and Mpox Vaccine Effectiveness Evaluation. During the next five-year period through our continued participation in EIP, Colorado proposes to maintain and expand active routine population-based surveillance and other special studies for current and emerging pathogens of public health importance. Through this work our goals and desired outcomes are to: 1) estimate and monitor the local and national burden of EIP pathogens, including new infections that may emerge during the project period; 2) describe demographic characteristic and clinical features associated with EIP pathogens and how these may change over time; 3) assess the impact of, and/or demonstrate need for vaccines, therapeutics, and public health disease control strategies for EIP pathogens to ultimately inform clinical and public health practice; 4) improve understanding of individuals and communities at risk of infection due to EIP pathogens, including the role of health disparity and opportunities to target interventions; 5) inform local and national prioritization of scarce public health resources; 6) maintain criti
cal expertise for public health surveillance and train and develop a public health surveillance workforce; and 7) contribute to the knowledge base around how epidemiology, laboratory, and informatics processes can combine to effectively identify and respond to emerging infectious disease threats.