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Defining Campylobacter and immune response related determinants in the pathogenesis of Guillain-Barr? syndrome patients in low-income countries

Award Number: K43TW011447
ORGANIZATION: FOGARTY INTERNATIONAL CENTER
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Project Summary Since the eradication of poliomyelitis, Guillain-Barré syndrome (GBS) has become a major health burden in low-income countries. The prognosis of GBS has not improved over the last two decades. Our group previously showed that the incidence, disease severity and mortality of GBS are higher in Bangladesh compared to the developed world. The preferred and most effective treatment for severe GBS is intravenous immunoglobulin (IVIg), yet some patients respond poorly to this recommended therapy. Little is known about the factors that influence disease pathogenesis and recovery in patients receiving IVIg therapy in low-income countries. Our long-term goal is to identify key determinants that predict IVIg treatment response in patients with GBS from low-income countries. The main hypothesis of the proposed project is that biological markers, nutritional factors or microbial strain differences may potentially influence the response of IVIg or clinical course and outcome of patients with GBS in low-income countries. Our objective is to identify key determinants to measure IVIg treatment responsiveness in patients with GBS in Bangladesh. Our specific aims will test the following hypotheses: Specific aim #1: We will identify whether biological markers serve as predictive factors to determine IVIg treatment response or whether nutritional status affects IVIg treatment response, the clinical course and GBS disease outcome in a low-income country. Specific aim #2: We will use high- throughput sequencing to generate and compare the whole genome sequences of Campylobacter jejuni strains isolated from IVIg-treated and non-treated patients with GBS, in order to identify the key genetic determinants responsible for disease pathogenesis and outcomes of IVIg treatment in low-income countries. The research proposed in this career development application is built upon ongoing, long-standing collaborative efforts between the icddr,b (Bangladesh), Erasmus University Medical Centre (the Netherlands), the University of Texas (USA), Washington State University (USA) and the National Institute of Neurosciences & Hospital (Bangladesh). The goal of this Career Development Program is to strengthen the skills necessary to become an independent researcher/investigator in host-pathogen interaction and advanced genomics research.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2023 ( Subtotal = $104,285 )
2023	2023	INTERNATIONAL CENTRE FOR DIARRHOEAL DISEASE RESEARCH, BANGLADESH	68, SHAHEED TAJUDDIN AHMED SARANI	DHAKA	DHAKA			BGD	International Research and Research Training	000	5	5/1/2023	NON-COMPETING CONTINUATION	$104,285
														Subtotal = $104,285

Issue Date FY: 2022 ( Subtotal = $98,966 )
2022	2022	INTERNATIONAL CENTRE FOR DIARRHOEAL DISEASE RESEARCH, BANGLADESH	68, SHAHEED TAJUDDIN AHMED SARANI	DHAKA	DHAKA			BGD	International Research and Research Training	002	4	4/21/2022	NON-COMPETING CONTINUATION	$98,966
2022	2021	INTERNATIONAL CENTRE FOR DIARRHOEAL DISEASE RESEARCH, BANGLADESH	68, SHAHEED TAJUDDIN AHMED SARANI	DHAKA	DHAKA			BGD	International Research and Research Training	001	3	11/8/2021	NON-COMPETING CONTINUATION	$0
2022	2021	INTERNATIONAL CENTRE FOR DIARRHOEAL DISEASE RESEARCH, BANGLADESH	68, SHAHEED TAJUDDIN AHMED SARANI	DHAKA	DHAKA			BGD	International Research and Research Training	000	3	11/1/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $98,966

Issue Date FY: 2021 ( Subtotal = $94,044 )
2021	2021	INTERNATIONAL CENTRE FOR DIARRHOEAL DISEASE RESEARCH, BANGLADESH	68, SHAHEED TAJUDDIN AHMED SARANI	DHAKA	DHAKA			BGD	International Research and Research Training	000	3	6/8/2021	NON-COMPETING CONTINUATION	$94,044
														Subtotal = $94,044

Issue Date FY: 2020 ( Subtotal = $89,472 )
2020	2020	INTERNATIONAL CENTRE FOR DIARRHOEAL DISEASE RESEARCH, BANGLADESH	68, SHAHEED TAJUDDIN AHMED SARANI	DHAKA	DHAKA	1212		BGD	International Research and Research Training	000	2	4/28/2020	NON-COMPETING CONTINUATION	$89,472
														Subtotal = $89,472

Issue Date FY: 2019 ( Subtotal = $85,249 )
2019	2019	INTERNATIONAL CENTRE FOR DIARRHOEAL DISEASE RESEARCH, BANGLADESH	68, SHAHEED TAJUDDIN AHMED SARANI	DHAKA	DHAKA	1212		BGD	International Research and Research Training	000	1	8/9/2019	NEW	$85,249
														Subtotal = $85,249

Grand Total All Awards = $472,016

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Defining Campylobacter and immune response related determinants in the pathogenesis of Guillain-Barr? syndrome patients in low-income countries

Award Number: K43TW011447

ORGANIZATION: FOGARTY INTERNATIONAL CENTER

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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