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Polycyclic aromatic hydrocarbons exposure and dietary risk of Esophageal squamous cell carcinoma in Uganda

Award Number: K43TW010715
ORGANIZATION: FOGARTY INTERNATIONAL CENTER
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/25/2017
PERIOD OF PERFORMANCE END DATE: 03/31/2022

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Polycyclic aromatic hydrocarbons exposure and dietary risk of Esophageal squamous cell carcinoma in Uganda - Project Summary Esophageal squamous cell carcinoma (ESCC) is the second leading cause of cancer-related death among males in East Africa. In southwestern Uganda, the prevalence of ESCC is increasing while the mean age of diagnosis is decreasing. In addition, ESCC continues to be complicated by late presentation and poor survival rates despite therapy. These changing prevalence and age of onset cannot be explained by known ESCC risk factors including human papillomavirus, alcohol and tobacco use as the prevalence of these risk factors remains low and unchanged. Additional, potentially modifiable risk factors that are contributing to the increase in ESCC have yet to be elucidated. Polycyclic aromatic hydrocarbons exposures in biomass fuel and/or dietary sources are potential explanations of the heightened risk of ESCC in sub-Saharan Africa. The current K43 application seeks to build on previous cross-sectional work that demonstrates male sex, smoking and alcohol as risk factors for ESCC. First, the award will provide the opportunity to strengthen my understanding of measurement and analysis of nutritional data, cancer and genetic epidemiology, and to complete successful apprenticeships with leading experts in cancer genomics, gastroenterology, and nutrition. The proposed training will include brief courses offered through Harvard University and Mbarara University of Science and Technology. Second, my cohort of ESCC patients will enable prospective examination of relationships of polycyclic aromatic hydrocarbon exposures with ESCC. I will also explore genetic and molecular signatures of ESCC in this population. The proposed career development activities and series of studies will deepen our understanding of the biological mechanisms through which biomass fuel and diet affects ESCC risk, with a primary focus on DNA methylation as a mediator. These findings can provide new understanding of pathways to ESCC that may lead to innovative ways to encourage multifactorial risk factor modification in individuals living in ESCC high burden areas in sub-Saharan Africa, a public health goal that has been difficult to attain.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2023 ( Subtotal = $0 )
2023	2021	MBARARA UNIVERSITY OF SCIENCE AND TECHNOLOGY	KABALE ROAD	MBARARA				UGA	International Research and Research Training	000	5	1/13/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2021 ( Subtotal = $92,989 )
2021	2021	MBARARA UNIVERSITY OF SCIENCE AND TECHNOLOGY	KABALE ROAD	MBARARA				UGA	International Research and Research Training	000	5	3/1/2021	NON-COMPETING CONTINUATION	$92,989
														Subtotal = $92,989

Issue Date FY: 2020 ( Subtotal = $91,585 )
2020	2020	MBARARA UNIVERSITY OF SCIENCE AND TECHNOLOGY	KABALE ROAD	MBARARA				UGA	International Research and Research Training	000	4	3/31/2020	NON-COMPETING CONTINUATION	$91,585
														Subtotal = $91,585

Issue Date FY: 2019 ( Subtotal = $91,153 )
2019	2019	MBARARA UNIVERSITY OF SCIENCE AND TECHNOLOGY	KABALE ROAD	MBARARA				UGA	International Research and Research Training	000	3	3/20/2019	NON-COMPETING CONTINUATION	$91,153
														Subtotal = $91,153

Issue Date FY: 2018 ( Subtotal = $89,598 )
2018	2018	MBARARA UNIVERSITY OF SCIENCE AND TECHNOLOGY	KABALE ROAD	MBARARA				UGA	International Research and Research Training	001	2	7/26/2018	NON-COMPETING CONTINUATION	$0
2018	2018	MBARARA UNIVERSITY OF SCIENCE AND TECHNOLOGY	KABALE ROAD	MBARARA				UGA	International Research and Research Training	000	2	5/17/2018	NON-COMPETING CONTINUATION	$89,598
														Subtotal = $89,598

Issue Date FY: 2017 ( Subtotal = $90,570 )
2017	2017	MBARARA UNIVERSITY OF SCIENCE AND TECHNOLOGY	KABALE ROAD	MBARARA				UGA	International Research and Research Training	000	1	9/20/2017	NEW	$90,570
														Subtotal = $90,570

Grand Total All Awards = $455,895

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Polycyclic aromatic hydrocarbons exposure and dietary risk of Esophageal squamous cell carcinoma in Uganda

Award Number: K43TW010715

ORGANIZATION: FOGARTY INTERNATIONAL CENTER

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/25/2017

PERIOD OF PERFORMANCE END DATE: 03/31/2022

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