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Psychological support based on positive suggestions in acute respiratory failure patients

Award Number: K23HL146741
ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP
PERIOD OF PERFORMANCE START DATE: 12/24/2019
PERIOD OF PERFORMANCE END DATE: 01/31/2025

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Psychological support based on positive suggestions in acute respiratory failure patients - PROJECT SUMMARY/ABSTRACT Up to two thirds of those who survive acute respiratory failure (ARF) requiring mechanical ventilation suffer from symptoms of anxiety, depression, or post-traumatic stress disorder (PTSD) after leaving the intensive care unit (ICU). Memories of frightening and delusional experiences in the ICU appear to be the strongest potentially modifiable risk factor. Research on the formation of fear and associated memories shows that if mitigating information about a traumatic event is introduced during the time between memory formation and its recall, the emotional experience of the memory can be modified in a positive manner. This means that in order to prevent mental health problems in ARF patients, psychological support needs to take place in parallel with medical treatment in the ICU. Previously, application of Psychological Support Based on Positive Suggestions (PSBPS) resulted in shorter duration of mechanical ventilation and decreased need for sedatives. We hypothesize that PSBPS can also mitigate mental health morbidity in ARF survivors. However, providing reliable PSBPS intervention is a challenge for busy ICU clinicians. Doulas, trained lay health care providers who provide emotional support to women in labor have been identified as a reliable yet affordable alternative. Given common elements of their services and our intervention, doulas are in an ideal position to administer PSBPS. The objective of this project is to refine and test a behavioral intervention to be administered in parallel with medical treatment in the ICU. This will be accomplished through two specific aims, which are: 1) to complete the pilot PSBPS with trained doulas and to refine the intervention based on stakeholder feedback and 2) to conduct a randomized controlled trial to evaluate the potential efficacy of PSBPS vs usual care in ARF patients on mental health morbidity and cognitive outcomes. In AIM 1, PSBPS will be performed on 30 ARF patients with subsequent semi-structured interviews of all involved stakeholders; patients will also complete anxiety, depression, acute stress/PTSD, and cognitive function evaluation as measured by validated instruments. For AIM 2, we will conduct a randomized, controlled trial to test the effectiveness of PSBPS. We hypothesize that ARF patients who receive standardized EPSCI will have fewer symptoms of anxiety, depression and acute stress/PTSD at ICU discharge and at 6-month follow-up, and better cognitive function. The proposed Career Development Award supports the NHLBI mission by striving to improve outcomes in ARF patients while training a junior investigator in essential skills to become an independent researcher.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = -$7,008 )
2025	2024	MAYO CLINIC	200 1ST ST SW	ROCHESTER	MN	55905	OLMSTED	USA	Lung Diseases Research	000	5	6/5/2025	NON-COMPETING CONTINUATION	-$7,008
														Subtotal = -$7,008

Issue Date FY: 2024 ( Subtotal = $185,760 )
2024	2024	MAYO CLINIC	200 1ST ST SW	ROCHESTER	MN	55905	OLMSTED	USA	Lung Diseases Research	000	5	11/8/2023	NON-COMPETING CONTINUATION	$185,760
														Subtotal = $185,760

Issue Date FY: 2023 ( Subtotal = $185,760 )
2023	2023	MAYO CLINIC	200 FIRST ST SW	ROCHESTER	MN	55905	OLMSTED	USA	Lung Diseases Research	000	4	11/25/2022	NON-COMPETING CONTINUATION	$185,760
														Subtotal = $185,760

Issue Date FY: 2022 ( Subtotal = $185,760 )
2022	2022	MAYO CLINIC	200 FIRST ST SW	ROCHESTER	MN	55905	OLMSTED	USA	Lung Diseases Research	000	3	11/26/2021	NON-COMPETING CONTINUATION	$185,760
														Subtotal = $185,760

Issue Date FY: 2021 ( Subtotal = $185,760 )
2021	2021	MAYO CLINIC	200 FIRST ST SW	ROCHESTER	MN	55905	OLMSTED	USA	Lung Diseases Research	000	2	11/24/2020	NON-COMPETING CONTINUATION	$185,760
														Subtotal = $185,760

Issue Date FY: 2020 ( Subtotal = $185,760 )
2020	2020	MAYO CLINIC	200 FIRST ST SW	ROCHESTER	MN	55905	OLMSTED	USA	Lung Diseases Research	000	1	12/23/2019	NEW	$185,760
														Subtotal = $185,760

Grand Total All Awards = $921,792

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Psychological support based on positive suggestions in acute respiratory failure patients

Award Number: K23HL146741

ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP

PERIOD OF PERFORMANCE START DATE: 12/24/2019

PERIOD OF PERFORMANCE END DATE: 01/31/2025

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