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Adoptive Immunotherapy for the Treatment of Viral Infections in Primary Immunodeficiency Disorders

Award Number: K23HL136783
ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP
PERIOD OF PERFORMANCE START DATE: 04/01/2017
PERIOD OF PERFORMANCE END DATE: 06/30/2020

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Adoptive Immunotherapy for the Treatment of Viral Infections in Primary Immunodeficiency Disorders - Project Summary/Abstract The overarching goal of this proposal is the development of the candidate into an independent investigator in the field of adoptive immunotherapy. With his clinical background in immunology and research experience in human immunobiology, the candidate is ideally positioned to fully realize the benefits of an NIH Mentored Career Development Award. The research proposal seeks to evaluate the use of adoptively transferred, virus-specific T-cells to treat viral infections in patients with primary immunodeficiency disorders (PID) who have not yet undergone hematopoietic stem cell transplantation. The specific aims of the project are: 1) To determine the safety and feasibility of banked, partially matched virus-specific T-cells for treatment of viral infections in primary immunodeficiency patients prior to hematopoietic stem cell transplantation, and 2) To determine whether virus-specific T-cells restore immunity against targeted viruses in patients. Collectively, these aims will determine if antiviral T-cell therapy may be a safe and effective bridge to transplantation for patients with primary immunodeficiency disorders, and will identify the optimal approach to using “off the shelf” banked T-cell products to combat viral infections, which has the potential to benefit a broad range of immune suppressed patients. The candidate has assembled an outstanding advisory team, who are highly qualified to guide him in the pursuit of his research and career goals. The primary mentor is Dr. Catherine Bollard, a world-renowned expert on adoptive T-cell therapies. The candidate's two co- mentors include Dr. Jordan Orange, a leading expert on primary immunodeficiency disorders and immunobiology, and Dr. Anamaris Colberg-Poley, a distinguished systems biologist and virologist. He will also collaborate with Dr. Daniel Douek (NIAID), a highly respected T-cell biologist, to pursue studies of virus-specific T-cell persistence and activity in vivo via TCRß sequencing. The candidate will participate in coursework and focused seminars designed to promote investigator independence by the end of the award period. The candidate will benefit from an ideal academic environment and extensive resources in the Center for Cancer and Immunology Research and the Clinical and Translational Science Institute at Children's National, as well as from supplemental training through Dr. Orange's Center for Human Immunobiology at Baylor College of Medicine, and Dr. Douek's Vaccine Research Center at NIH. In summary, this proposal describes a plan that is relevant, feasible, and will provide the necessary mentorship and training to allow the candidate to develop into an independent clinician- scientist in the field of adoptive immunotherapy for patients with PID.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2021 ( Subtotal = $0 )
2021	2019	CHILDREN'S RESEARCH INSTITUTE	111 MICHIGAN AVE NW	WASHINGTON	DC	20010	DISTRICT OF COLUMBIA	USA	Blood Diseases and Resources Research	000	3	2/9/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2019 ( Subtotal = $294,760 )
2019	2019	CHILDREN'S RESEARCH INSTITUTE	111 MICHIGAN AVE NW	WASHINGTON	DC	20010	DISTRICT OF COLUMBIA	USA	Blood Diseases and Resources Research	000	3	4/12/2019	NON-COMPETING CONTINUATION	$159,760
2019	2019	CHILDREN'S RESEARCH INSTITUTE	111 MICHIGAN AVE NW	WASHINGTON	DC	20010	DISTRICT OF COLUMBIA	USA	Blood Diseases and Resources Research	001	3	6/21/2019	SUPPLEMENT FOR EXPANSION	$135,000
														Subtotal = $294,760

Issue Date FY: 2018 ( Subtotal = $159,760 )
2018	2018	CHILDREN'S RESEARCH INSTITUTE	111 MICHIGAN AVE NW	WASHINGTON	DC	20010	DISTRICT OF COLUMBIA	USA	Blood Diseases and Resources Research	000	2	3/30/2018	NON-COMPETING CONTINUATION	$159,760
														Subtotal = $159,760

Issue Date FY: 2017 ( Subtotal = $159,760 )
2017	2017	CHILDREN'S RESEARCH INSTITUTE	111 MICHIGAN AVE NW	WASHINGTON	DC	20010	DISTRICT OF COLUMBIA	USA	Blood Diseases and Resources Research	000	1	3/11/2017	NEW	$159,760
														Subtotal = $159,760

Grand Total All Awards = $614,280

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Adoptive Immunotherapy for the Treatment of Viral Infections in Primary Immunodeficiency Disorders

Award Number: K23HL136783

ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP

PERIOD OF PERFORMANCE START DATE: 04/01/2017

PERIOD OF PERFORMANCE END DATE: 06/30/2020

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