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Risk Factors For Worse Lung Function iIn Latinos With Cystic Fibrosis

Award Number: K23HL133437
ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP
PERIOD OF PERFORMANCE START DATE: 02/01/2018
PERIOD OF PERFORMANCE END DATE: 05/31/2025

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Risk Factors For Worse Lung Function iIn Latinos With Cystic Fibrosis - PROJECT SUMMARY Cystic fibrosis (CF) is the second most common inherited childhood disease in the United States. CF is commonly thought of as a disease occurring only in whites; however, a third of patients in California are Hispanic. Hispanic children with CF have more severe lung disease and are 85% more likely to die annually than non-Hispanic white children with CF. Risk factors for severe lung function have been well-described in non-Hispanic white children with CF, yet little is known about risk factors for severe lung function in Hispanics. Our overall hypothesis is that Hispanic children have worse lung function than non-Hispanic white children due to differences in the exposure and impact of risk factors that determine lung function in CF. To test this hypothesis, we will investigate if Hispanic children acquire different respiratory infections or if infections affect lung function differentially than among non-Hispanic white children (Aim 1). CF-specific medications improve lung function but have not been studied specifically in Hispanic children. We will investigate the impact of these medications in Hispanic children (Aim 2). However, some important environmental and healthcare-related risk factors for lung function have not been collected by the CF Patient Registry. In our pilot cohort, we recruited Hispanic and non-Hispanic white children with CF to collect data on these potential risk factors: air pollution, secondhand smoke, language spoken, and acculturation (Aim 3). To investigate medication response in Latinos, we collected data about medical literacy and compliance (Aim 3). I have assembled a team of experienced scientists to address this critically important hypothesis. I am well equipped to successfully accomplish these training and research goals with a foundation of formal training in pediatric pulmonary, pediatric clinical pharmacology, and clinical research and the support of my mentors. In order to become a successful independent investigator in health disparities in cystic fibrosis, I need further training and hands-on experience in the following areas: methods to study health disparities in minority populations; developing and managing a pediatric cohort study; training in advanced biostatistics and study design in CF research; and overall research career development. This proposed research might identify potentially modifiable risk factors that differentially affect lung function in Hispanic children with CF. Interventions targeting these identified risk factors could improve the health of Hispanic children with CF, allowing them to have longer and more fulfilling lives. Importantly, this proposed K23 research and training plan will provide me with the essential tools for a successful R01 application and to advance my career in CF research.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2023	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94103	SAN FRANCISCO	USA	Lung Diseases Research	002	5	3/11/2025	NON-COMPETING CONTINUATION	$0
2025	2023	SEATTLE CHILDREN'S HOSPITAL	4800 SAND POINT WAY NE	SEATTLE	WA	98105	KING	USA	Lung Diseases Research	001	6	11/29/2024	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$93,871
2025	2023	SEATTLE CHILDREN'S HOSPITAL	4800 SAND POINT WAY NE	SEATTLE	WA	98105	KING	USA	Lung Diseases Research	003	6	9/30/2025	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$0
2025	2023	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94103	SAN FRANCISCO	USA	Lung Diseases Research	000	5	11/28/2024	NON-COMPETING CONTINUATION	-$93,871
														Subtotal = $0

Issue Date FY: 2024 ( Subtotal = $0 )
2024	2023	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Lung Diseases Research	000	5	1/27/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2023 ( Subtotal = $204,262 )
2023	2023	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Lung Diseases Research	000	5	11/23/2022	NON-COMPETING CONTINUATION	$204,262
														Subtotal = $204,262

Issue Date FY: 2022 ( Subtotal = $204,262 )
2022	2022	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Lung Diseases Research	000	4	11/12/2021	NON-COMPETING CONTINUATION	$204,262
														Subtotal = $204,262

Issue Date FY: 2021 ( Subtotal = $0 )
2021	2020	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Lung Diseases Research	000	3	4/1/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2020 ( Subtotal = $204,262 )
2020	2020	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Lung Diseases Research	000	3	7/2/2020	NON-COMPETING CONTINUATION	$204,262
														Subtotal = $204,262

Issue Date FY: 2019 ( Subtotal = $204,262 )
2019	2019	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Lung Diseases Research	000	2	8/2/2019	NON-COMPETING CONTINUATION	$204,262
														Subtotal = $204,262

Issue Date FY: 2018 ( Subtotal = $204,182 )
2018	2018	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 420	SAN FRANCISCO	CA	94103	SAN FRANCISCO	USA	Lung Diseases Research	001	1	8/1/2018	NEW	$0
2018	2018	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 420	SAN FRANCISCO	CA	94103	SAN FRANCISCO	USA	Lung Diseases Research	000	1	1/20/2018	NEW	$204,182
														Subtotal = $204,182

Grand Total All Awards = $1,021,230

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Risk Factors For Worse Lung Function iIn Latinos With Cystic Fibrosis

Award Number: K23HL133437

ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP

PERIOD OF PERFORMANCE START DATE: 02/01/2018

PERIOD OF PERFORMANCE END DATE: 05/31/2025

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