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Deciphering Preserved Autonomic Function after Spinal Cord Injury

Award Number: K23HD102663
ORGANIZATION: NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP
PERIOD OF PERFORMANCE START DATE: 08/24/2020
PERIOD OF PERFORMANCE END DATE: 12/31/2025

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Deciphering Preserved Autonomic Function after Spinal Cord Injury - Project summary/abstract: This training grant seeks funding to support the career development of Dr. Ryan Solinsky, a Physical Medicine & Rehabilitation physician-scientist at Spaulding Rehabilitation Hospital and Harvard Medical School, Boston, Massachusetts. Dr. Solinsky is establishing himself as an early career investigator in the clinical application and translation of autonomic neuroscience to improve functional outcomes for individuals after spinal cord injury. This K23 award will provide Dr. Solinsky the necessary support to accomplish the following training goals: 1) Broaden his understanding in computational neuroscience, with a focus on developing expertise in direct sympathetic nervous system recordings and spike train decoding, and in ambulatory monitoring of autonomic indicators; 2) Develop novel functional autonomic neuroimaging through collaboration with local experts 3) Grow his expertise in advanced statistical methods, appropriate for small-n studies of often heterogeneous populations such as those with spinal cord injury; and 4) Expand research project management, grantsmanship, and clinical research skills. To achieve these goals, Dr. Solinsky has developed a training plan with Dr. J. Andrew Taylor as his primary mentor. Dr. Taylor is a well-respected PhD scientist, with research expertise in autonomic control of the cardiovascular system as well as how this system is affected by exercise, specifically in individuals with spinal cord injury. Dr. Solinsky will have additional co-mentors: Dr. Teresa Kimberley, PT, PhD whose research focuses on translation of autonomic neuromodulation to improve outcomes after neurologic disease, and Dr. Roy Freeman, MBChB, a Neurologist and researcher specializing in clinical assessments of autonomic dysfunction. Further collaborators with expertise in functional neuroimaging, advanced statistical methods, and clinical spinal cord injury care are included in this proposal, which will be headquartered at Spaulding Rehabilitation Hospital in Boston, Massachusetts. Autonomic dysfunction following spinal cord injury is a significant clinical issue contributing to mortality and increased healthcare costs. Unfortunately, our understanding of autonomic dysfunction in this population is in its infancy. The overall objective of this research proposal is to characterize cardiovascular autonomic dysfunction after spinal cord injury using a battery of laboratory, ambulatory, and imaging-based tools. These will be focused on cardiovascular autonomic function, as this has the highest potential for clinical translation, with correlative structures to other components of the autonomic nervous system investigated. Research will specifically look to answer two questions: 1) Can discrete cardiovascular autonomic phenotypes be identified within those with spinal cord injury and correlated to clinical secondary autonomic complications? 2) Do those with the most dysregulated cardiovascular autonomic phenotypes demonstrate the highest rates of aberrant spinal cord functional connectivity on fMRI? Answering these questions will help us understand how autonomic regulation changes after spinal cord injury and how alterations translate to clinical secondary complications.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2024	MAYO CLINIC	200 1ST ST SW	ROCHESTER	MN	55905	OLMSTED	USA	Child Health and Human Development Extramural Research	000	5	7/17/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2024 ( Subtotal = $155,129 )
2024	2024	MAYO CLINIC	200 1ST ST SW	ROCHESTER	MN	55905	OLMSTED	USA	Child Health and Human Development Extramural Research	002	5	7/10/2024	NON-COMPETING CONTINUATION	$155,129
2024	2023	MAYO CLINIC	200 1ST ST SW	ROCHESTER	MN	55905	OLMSTED	USA	Child Health and Human Development Extramural Research	001	4	3/5/2024	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$87,423
2024	2022	THE SPAULDING REHABILITATION HOSPITAL CORPORATION	300 1ST AVE	CHARLESTOWN	MA	02129	SUFFOLK	USA	Child Health and Human Development Extramural Research	000	3	3/5/2024	NON-COMPETING CONTINUATION	-$87,423
														Subtotal = $155,129

Issue Date FY: 2023 ( Subtotal = $155,158 )
2023	2023	MAYO CLINIC	200 1ST ST SW	ROCHESTER	MN	55905	OLMSTED	USA	Child Health and Human Development Extramural Research	002	4	9/19/2023	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$155,158
2023	2022	SPAULDING REHABILITATION HOSPITAL CORPORATION, THE	300 FIRST AVE	CHARLESTOWN	MA	02129	SUFFOLK	USA	Child Health and Human Development Extramural Research	001	3	9/19/2023	NON-COMPETING CONTINUATION	$0
2023	2022	SPAULDING REHABILITATION HOSPITAL CORPORATION, THE	300 FIRST AVE	CHARLESTOWN	MA	02129	SUFFOLK	USA	Child Health and Human Development Extramural Research	000	3	7/21/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $155,158

Issue Date FY: 2022 ( Subtotal = $170,456 )
2022	2022	SPAULDING REHABILITATION HOSPITAL CORPORATION, THE	300 FIRST AVE	CHARLESTOWN	MA	02129	SUFFOLK	USA	Child Health and Human Development Extramural Research	000	3	7/19/2022	NON-COMPETING CONTINUATION	$170,456
														Subtotal = $170,456

Issue Date FY: 2021 ( Subtotal = $170,548 )
2021	2021	SPAULDING REHABILITATION HOSPITAL CORPORATION, THE	300 FIRST AVE	CHARLESTOWN	MA	02129	SUFFOLK	USA	Child Health and Human Development Extramural Research	000	2	7/19/2021	NON-COMPETING CONTINUATION	$170,548
														Subtotal = $170,548

Issue Date FY: 2020 ( Subtotal = $170,640 )
2020	2020	SPAULDING REHABILITATION HOSPITAL CORPORATION, THE	300 FIRST AVE	CHARLESTOWN	MA	02129	SUFFOLK	USA	Child Health and Human Development Extramural Research	000	1	8/21/2020	NEW	$170,640
														Subtotal = $170,640

Grand Total All Awards = $821,931

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Deciphering Preserved Autonomic Function after Spinal Cord Injury

Award Number: K23HD102663

ORGANIZATION: NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP

PERIOD OF PERFORMANCE START DATE: 08/24/2020

PERIOD OF PERFORMANCE END DATE: 12/31/2025

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