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Effects of general anesthetics on mitochondrial cellular distribution

Award Number: K08GM149981
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP
PERIOD OF PERFORMANCE START DATE: 05/01/2024
PERIOD OF PERFORMANCE END DATE: 10/31/2024

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Effects of general anesthetics on mitochondrial cellular distribution - Project Summary: The neuron is one of the highest energy-consuming cells within the body. It requires energy to maintain complex electrical gradients for neuron activation and signal transduction via synaptic vesicle release. The mitochondria are critical to efficiently create energy and their location within the cell is tightly regulated through the use of motor protein complexes kinesin (anterograde) and dynein (retrograde). General anesthetics have been shown to bind to kinesin motor proteins and decrease their processivity. However, the effect of that binding on cellular machinery, energy homeostasis and anesthetic sensitivity has not been studied. This project explores the affect general anesthetics have on mitochondrial location, and by extension energy, using both the zebrafish in vivo model organism and primary neural cell culture. I define mitochondrial movement alterations when exposed to different anesthetics. Next, I define zebrafish larvae and neural cells within two mitochondrial transport, kif5Aa and actr10, as well as how that movement is altered in response to different anesthetics. Finally, I will determine how changing the mitochondrial distribution within neurons affects whole organism behavior by testing for changes in sensitivity to anesthetics within zebrafish larvae. Completing this project will enhance my skills in neurobiology, mitochondrial biology, advanced statistics and programming. With these skills I will be able to create a unique niche within the field of anesthesia. This project will also give me to preliminary data to launch as an independent investigator and write an R01.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = -$73,812 )
2025	2024	TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, THE	3451 WALNUT STREET	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Biomedical Research and Research Training	001	1	4/11/2025	NEW	-$73,812
2025	2024	TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, THE	3451 WALNUT ST STE 440A	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Biomedical Research and Research Training	000	1	12/12/2024	NEW	$0
														Subtotal = -$73,812

Issue Date FY: 2024 ( Subtotal = $194,940 )
2024	2024	TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, THE	3451 WALNUT ST STE 440A	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Biomedical Research and Research Training	000	1	3/27/2024	NEW	$194,940
														Subtotal = $194,940

Grand Total All Awards = $121,128

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Effects of general anesthetics on mitochondrial cellular distribution

Award Number: K08GM149981

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP

PERIOD OF PERFORMANCE START DATE: 05/01/2024

PERIOD OF PERFORMANCE END DATE: 10/31/2024

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