Wednesday, February 18, 2026 2/18/2026

Adenosine Modulation of the Bi-Directional Relationship between Sleep and Migraine

Award Number: K01NS127944
ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP
PERIOD OF PERFORMANCE START DATE: 03/15/2024
PERIOD OF PERFORMANCE END DATE: 02/28/2029

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Adenosine Modulation of the Bi-Directional Relationship between Sleep and Migraine - PROJECT SUMMARY This proposal describes as 5-year mentored career development and research plan that facilitates the transition of Dr. Sinifunanya Nwaobi to an independent clinician scientist. Dr. Nwaobi is a Pediatric Neurologist who specializes in Headache and Pain Medicine at the UCLA Goldberg Migraine Program. Her overall career goal is to focus on managing adult and pediatric headache while leading translational research that will directly impact her patients’ care. One main career objective is to approach headache and pain research through the lens of a glial biologist, with a focus on astrocytes. The research proposal elucidates the bi-directional relationship between sleep and migraine by examining the specific mechanisms by which sleep modulates migraine pathophysiology. Aim 1 interrogates how both homeostatic and circadian components of sleep impact acute and chronic migraine using three clinically relevant rodent models of migraine. Aim 2 examines astrocytic, neuronal, and receptor-specific adenosine signaling to identify a drug-targetable mediator of the sleep-migraine connection. This tailored proposal builds upon Dr. Nwaobi’s prior experiences in glial biology, while expanding her skillset to include novel technologies that allow for minimally invasive in vivo monitoring of brain activity which are broadly applicable to the field of neuroscience. This research proposal will also expand her expertise in electrophysiology, in vivo fiber photometry, and large data statistical analyses. She will gain increased research exposure to the fields of headache, sleep, and glial biology. This work lays the foundation for future studies that will be the topic of subsequent K- and R- funding proposals. Importantly, this career development plan provides Dr. Nwaobi with world-class mentorship from leading experts in fields of headache medicine, circadian physiology, and glial biology. This diverse mentorship works to ensure her successful transition to an independent clinician scientist, foster collaborative research, and maximize the translational impact of the proposed studies. Overall, the proposed career development and research plan will directly advance the field of migraine with a focus on targeting drug-modifiable processes, while advancing Dr. Nwaobi towards research independence as a clinician scientist in headache and pain medicine.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $287,415 )
2026	2026	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90024	LOS ANGELES	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	3	1/22/2026	NON-COMPETING CONTINUATION	$287,415
														Subtotal = $287,415

Issue Date FY: 2025 ( Subtotal = $287,415 )
2025	2025	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90024	LOS ANGELES	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	2	2/12/2025	NON-COMPETING CONTINUATION	$287,415
														Subtotal = $287,415

Issue Date FY: 2024 ( Subtotal = $287,415 )
2024	2024	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10920 WILSHIRE BLVD STE 500	LOS ANGELES	CA	90024	LOS ANGELES	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	1	3/13/2024	NEW	$287,415
														Subtotal = $287,415

Grand Total All Awards = $862,245

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Adenosine Modulation of the Bi-Directional Relationship between Sleep and Migraine

Award Number: K01NS127944

ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP

PERIOD OF PERFORMANCE START DATE: 03/15/2024

PERIOD OF PERFORMANCE END DATE: 02/28/2029

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