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Novel time-efficient inspiratory muscle strength training for lowering systolic blood pressure and improving endothelial, cerebrovascular, and cognitive function

Award Number: K01HL153326
ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP
PERIOD OF PERFORMANCE START DATE: 08/03/2024
PERIOD OF PERFORMANCE END DATE: 07/31/2025

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Novel time-efficient inspiratory muscle strength training for lowering systolic blood pressure and improving endothelial, cerebrovascular, and cognitive function - PROJECT SUMMARY CANDIDATE: Daniel H. Craighead, PhD, is a postdoctoral fellow training in integrative physiology at the University of Colorado (CU) Boulder. In this K01 application, Dr. Craighead aims to determine the efficacy of high-resistance inspiratory muscle strength training (IMST), a novel and time-efficient lifestyle intervention, for lowering systolic blood pressure (SBP) and improving endothelial, cerebrovascular, and cognitive function. His immediate goal is to acquire the research training and professional skills necessary to transition to an independent, extramurally funded investigator. His long-term goal is to establish his own research program with a focus on identifying novel, evidence-based lifestyle interventions that lower blood pressure and prevent or delay the development of blood pressure-associated comorbidities and chronic diseases. CAREER DEVELOPMENT PLAN: Dr. Craighead's career development plan consists of: 1) acquiring new skills to assess cerebrovascular and cognitive function to support his proposed research plan; 2) train in new cellular and molecular techniques to assess changes in oxidative stress and nitric oxide-bioavailability; and 3) professional skill development through coursework; attendance/presentations at weekly journal clubs, CU seminars, and national scientific meetings; and regular interactions with his mentor team. ENVIRONMENT: The environment for Dr. Craighead's training plan will be outstanding. Dr. Craighead's primary mentor, Dr. Douglas Seals, and co-mentor, Dr. Michel Chonchol, are internationally recognized, NIH-funded scientists with strong records of successful mentoring in translational biomedical research. Co-mentor, Dr. Fiona Bailey, performed the pioneering work on high-resistance IMST, making her the foremost expert of this novel lifestyle intervention. Consulting mentor Dr. Zhiying You is Senior Biostatistician in the Department of Medicine at the CU Anschutz Medical Campus and regularly provides mentoring/consulting to trainees and faculty conducting clinical trials. Consulting mentor Dr. Philip Ainslie is the Canada Research Chair in Cerebrovascular Physiology with extensive experience assessing cerebrovascular function. Consulting mentor Dr. Brianne Bettcher is an Assistant Professor at the CU Anschutz Medical Campus and expert in assessing cognitive function. RESEARCH: Above-normal SBP is a highly prevalent condition, afflicting the majority of adults over age 50. Above-normal SBP increases the risk for developing cardiovascular diseases, stroke, cognitive decline, and other chronic conditions. This increased risk is largely attributable to the development of vascular dysfunction in the peripheral and cerebral arteries, secondary to an increase in oxidative stress and consequent reduction in nitric oxide-bioavailability. Healthy lifestyle practices are first-line therapies to lower SBP and decrease disease risk; however, adherence to these practices is poor due to their time-intensive nature. The proposed research will test the efficacy of time-efficient, high-resistance IMST for promoting adherence, lowering SBP, and improving endothelial, cerebrovascular, and cognitive function in adults with above-normal SBP.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2024	REGENTS OF THE UNIVERSITY OF MINNESOTA	200 OAK ST SE	MINNEAPOLIS	MN	55455	HENNEPIN	USA	Cardiovascular Diseases Research	001	6	11/21/2024	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$179,711
2025	2024	THE REGENTS OF THE UNIVERSITY OF COLORADO	3100 MARINE ST	BOULDER	CO	80309	BOULDER	USA	Cardiovascular Diseases Research	000	5	11/20/2024	NON-COMPETING CONTINUATION	-$179,711
														Subtotal = $0

Issue Date FY: 2024 ( Subtotal = $179,712 )
2024	2024	THE REGENTS OF THE UNIVERSITY OF COLORADO	3100 MARINE ST	BOULDER	CO	80309	BOULDER	USA	Cardiovascular Diseases Research	000	5	7/12/2024	NON-COMPETING CONTINUATION	$179,712
														Subtotal = $179,712

Issue Date FY: 2023 ( Subtotal = $179,712 )
2023	2023	REGENTS OF THE UNIVERSITY OF COLORADO, THE	3100 MARINE ST STE 481 572 UCB	BOULDER	CO	80309	BOULDER	USA	Cardiovascular Diseases Research	000	4	6/30/2023	NON-COMPETING CONTINUATION	$179,712
														Subtotal = $179,712

Issue Date FY: 2022 ( Subtotal = $179,712 )
2022	2022	REGENTS OF THE UNIVERSITY OF COLORADO, THE	3100 MARINE ST STE 481 572 UCB	BOULDER	CO	80309	BOULDER	USA	Cardiovascular Diseases Research	000	3	8/3/2022	NON-COMPETING CONTINUATION	$179,712
														Subtotal = $179,712

Issue Date FY: 2021 ( Subtotal = $179,712 )
2021	2021	REGENTS OF THE UNIVERSITY OF COLORADO, THE	3100 MARINE ST STE 481 572 UCB	BOULDER	CO	80309	BOULDER	USA	Cardiovascular Diseases Research	000	2	8/5/2021	NON-COMPETING CONTINUATION	$179,712
														Subtotal = $179,712

Issue Date FY: 2020 ( Subtotal = $179,712 )
2020	2020	REGENTS OF THE UNIVERSITY OF COLORADO, THE	3100 MARINE ST STE 481 572 UCB	BOULDER	CO	80309	BOULDER	USA	Cardiovascular Diseases Research	000	1	7/24/2020	NEW	$179,712
														Subtotal = $179,712

Grand Total All Awards = $898,560

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Novel time-efficient inspiratory muscle strength training for lowering systolic blood pressure and improving endothelial, cerebrovascular, and cognitive function

Award Number: K01HL153326

ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP

PERIOD OF PERFORMANCE START DATE: 08/03/2024

PERIOD OF PERFORMANCE END DATE: 07/31/2025

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