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Sleep and Circadian Rhythms in Adolescence: Epigenetic Pathways of Cardiometabolic Risk

Award Number: K01HL151673
ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP
PERIOD OF PERFORMANCE START DATE: 05/15/2020
PERIOD OF PERFORMANCE END DATE: 04/30/2025

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Sleep and Circadian Rhythms in Adolescence: Epigenetic Pathways of Cardiometabolic Risk - ABSTRACT Candidate: The PI is a Research Assistant Professor and nutritional epidemiologist whose primary career goal is to apply epigenetic approaches to improve the understanding of the interplay of sleep/circadian rhythms and nutrition on long-term cardiometabolic health risk. The proposed award includes a 5-year plan of training and research centered on circadian rhythms, epigenetics, study design, and skills required to lead a research team. Research context: Insufficient and mistimed sleep is recognized as a risk for adverse cardiometabolic outcomes. Adolescents are especially vulnerable as they have high prevalence of both short sleep duration and misaligned sleep timing. Yet, the unique contributions of sleep duration and circadian misalignment to cardiometabolic risk is unclear. Uncovering the epigenetic mechanisms behind these relationships is a highly promising avenue for this public health issue. Recent cross-sectional evidence shows that epigenetic alterations of metabolic and circadian genes might play an intermediary role in the relationships between sleep/circadian rhythms and cardiometabolic health, yet longitudinal investigations are scarce. The application of epigenetic approaches to identify potential mechanisms that link sleep to cardiometabolic health is novel. Research Objectives: The aims are two-fold: 1) to evaluate the independent associations of sleep duration and timing with cardiometabolic health among adolescents and 2) to examine epigenetic associations between insufficient/mistimed sleep and cardiometabolic health. Research Plan: The PI will analyze existing data from an NIH-funded established cohort study of adolescents in Mexico City with highly variable sleep patterns (some participants' sleep patterns are constrained by morning school shifts while others have more flexibility due to an afternoon school shift). Associations between objectively collected sleep data (7-days of actigraphy) and cardiometabolic biomarkers (adiposity, blood pressure, and insulin resistance collected at two time points 24 months apart) will be analyzed. Stored leukocytes will be used to measure gene expression and epigenome-wide DNA methylation. Longitudinal and epigenome-wide statistical analyses will be conducted. Career Goals and Development: The PI will gain expertise in assessment of circadian rhythms, epigenetics laboratory investigation, and epidemiological study design through didactic and hands-on experiences. She will also advance in her leadership, mentorship, and grantsmanship skills, and by the end of the training period will apply for an R01 centered on sleep/circadian rhythms, nutrition, and epigenetics. Environment: Resources available to the PI include a well-rounded and supportive team of mentors representing the fields of sleep/circadian rhythms, epigenetics, nutrition and cardiometabolic health; and the excellent research infrastructure at the University of Michigan School of Public Health where the PI has been guaranteed 80% of time devoted to the research goals delineated in the proposal.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2024	REGENTS OF THE UNIVERSITY OF MICHIGAN	1109 GEDDES AVE STE 3300	ANN ARBOR	MI	48109	WASHTENAW	USA	National Center on Sleep Disorders Research	000	5	7/21/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2024 ( Subtotal = $207,799 )
2024	2024	REGENTS OF THE UNIVERSITY OF MICHIGAN	1109 GEDDES AVE, SUITE 3300	ANN ARBOR	MI	48109	WASHTENAW	USA	National Center on Sleep Disorders Research	001	5	4/17/2024	NON-COMPETING CONTINUATION	$137,857
2024	2024	REGENTS OF THE UNIVERSITY OF MICHIGAN	1109 GEDDES AVE, SUITE 3300	ANN ARBOR	MI	48109	WASHTENAW	USA	National Center on Sleep Disorders Research	000	4	3/27/2024	SUPPLEMENT FOR EXPANSION	$69,942
														Subtotal = $207,799

Issue Date FY: 2023 ( Subtotal = $137,857 )
2023	2023	REGENTS OF THE UNIVERSITY OF MICHIGAN	503 THOMPSON STREET	ANN ARBOR	MI	48109	WASHTENAW	USA	National Center on Sleep Disorders Research	000	4	4/5/2023	NON-COMPETING CONTINUATION	$137,857
														Subtotal = $137,857

Issue Date FY: 2022 ( Subtotal = $137,857 )
2022	2022	REGENTS OF THE UNIVERSITY OF MICHIGAN	503 THOMPSON ST	ANN ARBOR	MI	48109	WASHTENAW	USA	National Center on Sleep Disorders Research	000	3	5/3/2022	NON-COMPETING CONTINUATION	$137,857
														Subtotal = $137,857

Issue Date FY: 2021 ( Subtotal = $137,857 )
2021	2021	REGENTS OF THE UNIVERSITY OF MICHIGAN	503 THOMPSON ST	ANN ARBOR	MI	48109	WASHTENAW	USA	National Center on Sleep Disorders Research	000	2	6/26/2021	NON-COMPETING CONTINUATION	$137,857
														Subtotal = $137,857

Issue Date FY: 2020 ( Subtotal = $137,857 )
2020	2020	REGENTS OF THE UNIVERSITY OF MICHIGAN	503 THOMPSON ST	ANN ARBOR	MI	48109	WASHTENAW	USA	National Center on Sleep Disorders Research	000	1	5/15/2020	NEW	$137,857
														Subtotal = $137,857

Grand Total All Awards = $759,227

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Sleep and Circadian Rhythms in Adolescence: Epigenetic Pathways of Cardiometabolic Risk

Award Number: K01HL151673

ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP

PERIOD OF PERFORMANCE START DATE: 05/15/2020

PERIOD OF PERFORMANCE END DATE: 04/30/2025

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