The goal of the Prevent! Substance Abuse Coalition of Tacoma, organized in 2014, is to address local conditions that include the impact of the legalization of marijuana, the privatization of alcoholic beverages, and the prevalence of opioid-based prescription drugs, on youth substance use. The coalition is a unique, city wide (12 zip codes) prevention effort. It expands the previous Tacoma Drug-Free Coalition that was organized in 2001 to specifically address substance use, violence and gang-related issues in the targeted Hilltop Neighborhood (4 specific zip codes) of Tacoma. During this period. The Prevent! Substance Abuse Coalition has impacted the four core measures of: 1) past 30-day use, 2) perception of risk of harm of drugs by youth, 3) perception by youth of parental disapproval, and 4) peer disapproval of substance use. There have been reductions in the rates of alcohol and tobacco use as measured by the Healthy Youth Survey (2016). However, the rate of marijuana use has increased significantly along with an alarming increase in the use of opioid-based prescription drugs and E-cigarettes. The Prevent! Substance Abuse Coalition will use the results of the Healthy Youth Survey to assess, plan, design, implement and evaluate prevention efforts city-wide. The Coalition will partner with the 12-sector representatives and other community resources to provide needed prevention.